IMitochondria yenza okungaphezulu kunokubonelela nje ngamandla kwiiseli.
Ixesha lokufunda eliqikelelweyo: 9 imizuzu
Ungandivi kakubi. Banento yonke enokuyenza ngamandla. Kwaye ngenxa yokuba zibaluleke kakhulu kwimveliso yamandla, zidlala indima ebalulekileyo kwi-metabolism. Kwaye ngenxa yoko, baphambili kwinqanaba kwi-Metabolic Psychiatry.
Siva ukuba i-mitochondria zizindlu zamandla zeseli ngokupheleleyo kuyo yonke indawo. Okanye ndenza kwizangqa endizixhomayo. Kwaye uya kuyibona ixelwa kuzo zonke iiposti zebhlog kule webhusayithi. Ukunxibelelana nge-mitochondria zezona zindlu zamandla kwiiseli zakho yeyona ndlela ilula kwaye ilula kakhulu yokufikelela kuwe oyidingayo kumandla e-neuronal. Kulula ukuyiqonda. Ukuba asinazo iibhetri ezisebenzayo kwitotshi, isibane asiyi kusebenza. Kwaye ukuba iibhetri zethu ziyafa, ziya kusebenza, kodwa hayi kakuhle. Kwaye oko kuya kwingqondo yethu xa sinokungasebenzi kakuhle kwe-mitochondrial. Iiseli azikwazi ukwenza umsebenzi omninzi ekufuneka ziwenze ukuze zikugcine uncwina kakuhle.
Kodwa kwabo bafuna ukwazi ngakumbi, kubalulekile ukwazi ukuba i-mitochondria ingaphezulu kakhulu kunezindlu zamandla zeeseli zakho. Ke kumdla wokuqonda okugqibelele ngakumbi malunga nokuba zeziphi ezi organelles zincinci zomlingo ndibhale le post yebhlog!
Qaphela: Andisebenzisi igama lomlingo ngokulula. Ukuba awulithandi igama lomlingo, ngandlela zonke, beka endaweni yegama elithi quantum. Kuba oko kuchanekile kwaye kuhle kakhulu kupholile. Kodwa ngaphaya komda weli nqaku lincinci (andiyofiziksi).
I-Mitochondria iguqulela phakathi kwehlabathi le-quantum kunye ne-macroscopic kunye sebenzisa i-quantum tunneling yee-electron ukunciphisa imiqobo yokuvula amandla ekuhambeni kwe-electron. Itonela ye-electron ibonakaliswe ngokubanzi kwi-Complex I yekhonkco lothutho lwe-electron.
Bennett, JP (2019). I-hypothesis yonyango: Izifo ze-neurodeergenerative zivela kumonakalo we-oxidative kwi-electron tunneling proteins kwi-mitochondria. Iingqikelelo zonyango, 127, 1-4.
Ke masingene kwezinye izinto i-mitochondria edlala indima ebalulekileyo ngaphandle kwemveliso yamandla emangalisayo. Ukuba ubunethemba lenqaku le-mitochondria elikhethekileyo kwizidlo ze-ketogenic, unethamsanqa. Kuba ndibhale enye. Ungayifumana apha:
Impendulo yoxinzelelo
Kukho uxinzelelo lomzimba kunye noxinzelelo lwengqondo. Kwaye amandla omzimba wakho wokuphatha uxinzelelo lwalo naluphi na uhlobo lwehla ekusebenzeni kwe-mitochondrial. Ngaba ukhe wachanabeka kwintsholongwane okanye kwiibhaktheriya ezicinezela amajoni akho omzimba? I-Mitochondria ilawula umsebenzi wakho we-immune system. Ngaba ujongene noxinzelelo lwengqondo olucela umngeni ebomini bakho? I-Mitochondria ilawula ukukwazi kweseli yakho ukuziqhelanisa, ukusinda kunye nokuqina ngakumbi ngokuqalisa utshintsho kuzo zombini imbonakalo yemfuza kunye nemetabolism. Ukuba awunayo i-mitochondria esempilweni kwaye ininzi yokuxhasa iiseli iiseli ezininzi ziyafa, okanye ngakumbi. Zijika zibe zombies (senescence) ezimpompa imiqondiso eyoyikekayo eyonyusa uxinzelelo lwakho lwe-oxidative kwaye yenze mandundu iimpawu zakho.
Ukuveliswa kweHormone
Ukuba yiseli eyenza iihomoni, yiseli efuna amandla angaphezulu kunoninzi kwaye oko kuthetha ukuba i-mitochondria yakho ijongene ne-hormone synthesis. Kuko oko. Iihomoni zeSterol ezifana ne-estrogen, testosterone, kunye ne-cortisol. Mitochondria bamba isitshixo. Ekunene ukubonelela ngee-enzymes ezifunekayo ukuqalisa ukuveliswa kwehomoni.
Kungenxa yoko le nto unyango lwakho lweyeza olusebenzayo lokudinwa kwe-adrenal lungasebenzi. Ukukunika i-sterols yezityalo ukuze utshintshe i-cortisol yakho ayithethi ukungasebenzi kwe-mitochondrial okuqhubekayo. Kungenxa yoko le nto ukuya kunyango lokutshintshwa kwehomoni ayisiyiyo "ingcambu engunobangela" wongenelelo. Ukuba iihomoni zakho ziphumile, luphawu lokungasebenzi kakuhle kwe-mitochondrial. Inqaku lokungenelela kukuphucula umsebenzi wakho we-mitochondrial.
Xelela abahlobo bakho.
Ukucoca ubumdaka
Phantse inqaku ngalinye kule webhusayithi lithetha ngendima yoxinzelelo lwe-oxidative kwisifo sengqondo kunye nokuphazamiseka kwengqondo. Uxinzelelo lwe-oxidative yinto esiyibiza ngokuba ngumthwalo wokuzama ukulungisa umonakalo owenzeka ngenxa ye-Reactive Oxygen Species (ROS). Xa i-mitochondria yakho ininzi kwaye isempilweni ngokubanzi unalo lonke uncedo oludingayo ukuze ulungise amanqanaba aqhelekileyo omonakalo owenzeka ekubeni uphila kwaye uhamba kwihlabathi.
…mitochondria isebenza njenge-ROS janitors.
(Palmer, 2022, iphepha 126)
I-mitochondria eninzi kwaye isebenza kakuhle iyafuneka ukuze kugcinwe uxinzelelo lwe-oxidative. Kwaye ukugcina uxinzelelo lwe-oxidative luyimfuneko ukuze ube nengqondo esebenzayo. Uxinzelelo lwe-oxidative olungagcinwanga lukhokelela kwiinkqubo ze-neurodeergenerative ezichaphazela isimo sengqondo kunye nokusebenza kwengqondo. Mitochondria ziluncedo ekusebenzeni nasekugcinweni kweenkqubo ze-antioxidant zangaphakathi zomzimba wakho. Kwaye njengoko nditshilo ngokuphindaphindiweyo kuwo onke amanqaku eblogi, awuyi kusebenzisa iVithamin C, i-turmeric, okanye i-curcumin indlela yakho yokuphuma kumthwalo woxinzelelo lwe-oxidative evela ekusebenzeni kakubi okanye amanani angonelanga e-mitochondria.
Buza naliphi na inani labantu abathatha iidosi ezinkulu ze-antioxidants ngokwengcebiso yabo yonyango olusebenzayo abasazama ukuziva kakuhle.
Xelela abahlobo bakho ngaloo ndawo, nabo.
Ukuba usabhidekile kancinci malunga nomahluko phakathi koxinzelelo lwe-oxidative kunye ne-neuroinflammation kunye nendlela ezinxulumene ngayo, unokujonga eli nqaku lingezantsi:
Kodwa i-mitochondria ingaphezulu kweqela lokucoca xa kusenzeka isiphithiphithi. Banceda ukugcina iiseli kuzo zonke iintlobo zeendlela. Balawula inani leeseli ezidaliweyo, zinceda ukulawula ukuba zeziphi iindibano ezithenwayo kwaye zeziphi ezihlala, kwaye ziluncedo kwinkqubo yokuhlaziya eyinxalenye yokusebenza kweseli enempilo (i-autophagy, i-cell apoptosis - uhlobo oluhle lokufa kweseli). Akukhona nje ukucoca ukungcola emva kokuba kwenzekile. I-Mitochondria iqinisekisa ukubonakaliswa kwemfuza okunempilo kunye nokusebenza kweeseli ukunciphisa amathuba okuba kwenzeke umonakalo omkhulu kwasekuqaleni.
Ukuveza intetho
Eyona nto iphambili apha kukuba iijini zakho aziyi kuziveza kanye ngaphandle kokusebenza kwe-mitochondria esempilweni. Malunga neminyaka eyi-20 edlulileyo bafumanisa ukuba i-mitochondria yayifuneka ukuthutha iprotheni eyanceda ukulawula ukubonakaliswa kofuzo. I-Mitochondria ine-DNA yayo kunye neekhowudi ze-DNA zeeprotheni ezilawula ukubonakaliswa kofuzo. Kwaye loo ntetho yemfuza ineempembelelo kwiimpendulo zoxinzelelo, imetabolism, kunye nomsebenzi we-antioxidant. Xa abaphandi bedlala ne-mitochondria ngokuyiqhekeza (ukunciphisa amandla abo okusebenza) bafumanisa ukuba iingxaki ezininzi ze-epigenetic zenzeka.
Ithetha ntoni le nto?
Kuthetha ukuba awufuni ukuba imizila yemfuza yakho iziveze ngeendlela ezihlekisayo ezibangela iingxaki kunye neempawu kwaye zikwenze (kunye nengqondo yakho) ubudala ngokukhawuleza, kungcono ubeke ugxininiso lwakho ekufundeni indlela yokukhaba-esile esempilweni, kunye ne-mitochondria eyonwabileyo.
Ukuba ubunethemba lokuqonda ngcono kancinci indlela ii-ketones ezichaphazela ngayo ukubonakaliswa kofuzo, ungalithanda eli nqaku ndilibhale apha:
I-Neurotransmitter Synthesis
I-Mitochondria ithanda ukuhlala kwi-synapses. Ukuba i-mitochondria yakho inqabile ngenani okanye into ingena endleleni yokukwazi ukuhamba apho kufuneka khona, ngoko awuzenzi iineurotransmitters zakho. Kwaye ukuba i-mitochondria yakho inqabile ngenani okanye ayisebenzi okanye iyagula ke ii-neurotransmitters zinokungalingani.
Kwaye ii-neurotransmitters ezingalungelelananga zikhokelela kungekuphela nje kwiingxaki zengqondo kodwa iingxaki zengqondo, nazo. Udinga i-mitochondria enempilo kunye neninzi ukuze udibanise, ukhulule, kwaye uphinde uthathe ii-neurotransmitters zakho kwaye emva koko uvelise i-enzymes ezophulayo. Ndiyazi sonke sicinga ukuba umbono kukuba ii-neurotransmitters zakho zixhonywe kwii-synapses ixesha elide, kodwa oko kunokubangela iingxaki zayo xa zingenakophulwa.
Luphawu lwengxelo. Ii-neurotransmitters eziveliswe kwaye zisetyenziswe emva koko zinike imiyalezo ebalulekileyo ye-mitochondria esetyenziselwa ukwenza ngcono ukusebenza kwengqondo yakho. Akukho mntu ujonge impumelelo ekusebenzeni kwengqondo yakho njengabahlobo bakho abanamandla, abancinci bemitochondrial. Ngubani ovuyela ukufikelela kwakho kwimo ezinzileyo? Ngubani ofuna ukuba uzive uhlakaniphile, ukhona, kwaye ukwazi?
Yimitochondria yakho.
Kwiingcali zengqondo zisebenzisa ngokuyinhloko amayeza ukuzama ukwandisa okanye ukunciphisa i-neurotransmitters ethile ngaphandle kokuqwalasela impilo ye-mitochondrial, ndikukhuthaza ukuba uhlolisise amanye amathuba oqeqesho lwe-Metabolic Psychiatry anikezelwe kwiphepha elingezantsi.
isiphelo
Ukuba awugxininisi kwenye indawo yomsebenzi ophuculweyo ekubuyiseni kwakho kunomsebenzi we-mitochondrial, uya kube uzenzela inkonzo emnandi. Kukho iindlela ezintle kakhulu zokuphucula umsebenzi we-mitochondrial, kwaye enye yeyona ndlela inamandla yokungenelela ekunyuseni inani le-mitochondrial kunye nomsebenzi ophuculweyo we-mitochondrial uquka ukutya kwe-ketogenic.
Ngoba? Ngenxa yokuba ukutya kwe-ketogenic kwandisa inani le-mitochondria kunye nokuphucula impilo kunye nokusebenza kwe-mitochondria. Ukutya kwe-ketogenic kukungenelela kwe-mitochondrial echaphazela imetabolism kunye nayo yonke eminye imisebenzi ebalulekileyo ebaluleke kakhulu ekusebenzeni kwengqondo echazwe kweli nqaku elifutshane.
Apha ngezantsi kukho amanqaku athetha ngokuba kutheni ukutya kwe-ketogenic, kunye nokulawulwa okulandelayo kwe-mitochondria okuphumela, lunyango olumangalisayo loxilongo olwahlukeneyo.
Ukuba awuboni ukuxilongwa onomdla wokufunda malunga, skrolela ezantsi kwibar yokukhangela emazantsi ephepha!
Ngoku ekubeni unombono ongcono weminye yemisebenzi ebonelelwa yi-mitochondria, ukwimeko engcono kakhulu yokonwabela izithuba zebhlog kule webhusayithi.
Ukuba ungathanda ukuphonononga inkqubo ye-intanethi kuhambo lwakho lokufunda zonke iindlela onokuziva ngcono ngazo, ndiyakukhuthaza ukuba ufunde ngakumbi ngeNkqubo yam yokuBuyisela inkungu yengqondo.
Ucaphulo
Anderson, AJ, Jackson, TD, Stroud, DA, & Stojanovski, D. (2019). I-Mitochondria-i-hubs zokulawula i-biochemistry yeselula: iingcamango ezivelayo kunye nothungelwano. Vula ibhayoloji, 9(8), 190126. https://doi.org/10.1098/rsob.190126
Bennett, JP (2019). I-hypothesis yonyango: Izifo ze-neurodeergenerative zivela kumonakalo we-oxidative kwi-electron tunneling proteins kwi-mitochondria. Unyango lwezonyango, 127, 1-4. https://doi.org/10.1016/j.mehy.2019.03.034
Bennett, JP, & Onyango, IG (2021). Amandla, i-Entropy kunye ne-Quantum Tunneling yeeProtons kunye ne-Electron kwi-Brain Mitochondria: Ubudlelwane nokukhubazeka kwe-Mitochondrial kwi-Aging-Related Human Brain Diseases and therapeutic Measures. Iintsholongwane, 9(2), iSiqendu 2. https://doi.org/10.3390/biomedicines9020225
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Ingqondo yeMetabolic (uMlawuli). (2022, Novemba 30). I-Mitochondria kwi-Brain kunye nomzimba-uMartin Picard PhD. https://www.youtube.com/watch?v=u51JSv4AK-0
Palmer, C. (2022). Amandla engqondo (uhlelo loku-1). https://a.co/d/hKy6x2A
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