Ukutya kwe-ketogenic kunokunceda njani ukunyanga iimpawu ze-Generalized Anxiety Disorder (GAD)?

Ukuphazamiseka Okubanzi kweXhala

Izidlo ze-Ketogenic ziyakwazi ukuguqula ubuncinane ezine ze-pathologies esizibona ziphantsi kwe-Generalized Anxiety Disorder (GAD). Ezi pathologies ziquka i-glucose hypometabolism, ukungalingani kwe-neurotransmitter, ukuvuvukala, kunye noxinzelelo lwe-oxidative. Ukutya kwe-ketogenic kunyango olunamandla lokutya oluye lwaboniswa ukuba luchaphazele ngokuthe ngqo ezi ndlela ezine ezisisiseko eziye zachongwa ukuba zibandakanyeke kwi-Generalized Anxiety Disorder (GAD) iimpawu.

intshayelelo

Kule post yebhlog, ndinguye hayi ukuya kuchaza iimpawu okanye amazinga okuxhaphaka kwe-Generalized Anxiety Disorder (GAD). Esi sithuba asenzelwanga ukuxilonga okanye ukufundisa ngolo hlobo. Ukuba ufumene le posti yebhlog, uyazi ukuba yintoni i-GAD kwaye kusenokwenzeka ukuba wena okanye umntu omthandayo usenokuba sele ephethwe ziimpawu ezibuthathaka ezinxulumene nayo.

Ukuba ufumene le post blog, ukhangela iindlela zonyango. Uzama ukufumana iindlela zokuziva ungcono kwaye uphile.

Ekupheleni kwesi sithuba seblogi, uya kuba nakho ukuqonda ezinye zeendlela ezisisiseko ezingahambi kakuhle kwiingqondo zabantu abaphethwe yi-GAD kunye nendlela ukutya kwe-ketogenic kunokunyanga ngayo nganye kubo.

Uza kubuya ubone ukutya kwe-ketogenic njengonyango olunokwenzeka kwi-Generalized Anxiety Disorder (GAD) iimpawu okanye njengendlela ehambelanayo yokusetyenziswa kwengqondo kunye / okanye endaweni yamayeza.

I-psychopharmacology yangoku ye-Generalized Anxiety Disorder (GAD) iquka i-serotonin reuptake inhibitors (SSRIs) ekhethiweyo kunye ne-serotonin-norepinephrine reuptake inhibitors (SNRIs). Ezi antidepressants lukhetho lokuqala lwamayeza kuzo zonke iziphazamiso zoxinzelelo. Amayeza ongezelelweyo angabandakanya i-calcium modulator pregabalin, i-tricyclic antidepressants, i-buspirone, i-moclobemide, i-anticonvulsants, kunye ne-atypical antipsychotics.

Kutheni ezi ziyobisi zimiselwe i-Generalized Anxiety Disorder (GAD)?

La machiza azama ukulungelelanisa iinkqubo ezinzima ze-neurotransmitter ezibandakanya i-serotonin, i-norepinephrine, kunye ne-GABA. Ezi zezona njongo zixhaphakileyo zeendlela ze-psychopharmacological kolu kuphazamiseka. Ezi zezinye zokungalingani kwe-neurotransmitter esiyibonayo kwizigulane ezine-Generalized Anxiety Disorder (GAD). 

Nangona kunjalo, iimpendulo zesigulana kula mayeza enzelwe ukuchaphazela ezi nkqubo ze-neurotransmitter zihlala zisilela kwisiqabu seempawu.

Ngaphandle kokusebenza kweendlela ezikhoyo ze-pharmacological, izigulane ezininzi aziphumeleli ukuxolelwa ngokupheleleyo, kwaye iindlela zonyango zonyango zifanelekile.

UMelaragno A., uSpera V., uBui E. (2020) – https://doi.org/10.1007/978-3-030-30687-8_13

Ke luhlobo luni lwe-pathology kwingqondo esiyibonayo kwi-Generalized Anxiety Disorder (GAD)?

Ngaphambili kule post yangaphambili ndangena kwiinkcukacha malunga nendlela ukutya kwe-ketogenic kunokuguqula ngayo iimpawu zokuxhalaba.

Njani? Ngokuchaphazela iindawo ezine ze-pathology ezibonwa kwezi ngxaki.

  • IGlucose Hypometabolism
  • Neurotransmitter Ukungalingani
  • Ukuvutha
  • Uxinzelelo lwe-oxidative.

Makhe siphonononge ukuba yeyiphi kwezi enokuthi ibekho okanye ingabikho kwi-pathology yeGeneralized Anxiety Disorder (GAD).

I-Glucose Hypometabolism kwingqondo yabo bane-Generalized Anxiety Disorder (GAD)

I-Hypometabolism yobuchopho ithetha ukuba ezinye izakhiwo zobuchopho aziwasebenzisi kakuhle amandla. Abantu abane-Generalized Anxiety Disorder babonwa ukuba bahlupheke kwi-hypometabolism kwi-basal ganglia kunye nomcimbi omhlophe. I-Hypometabolism ye-basal ganglia inokubonwa kukuphazamiseka kokulala apho abantu bayasokola kunye nomjikelo wabo wokuvuka. Ngaba i-hypometabolism yale ndawo yobuchopho inegalelo ekungakwazini ukulala okanye ukulala ngenxa yexhala? Mhlawumbi. Andikwazanga ukufumana apho olu xhulumaniso lunokwenzeka luphononongwe kwi-Generalized Anxiety Disorder populations.

Ngokuyintloko i-basal ganglia ibandakanyeka ekufundeni kweemoto, ulandelelwano, ukuziphatha kwentshukumo, kunye nenkumbulo. Ngelixa ukunyakaza okanye imiba yemoto ingeyonxalenye yenkqubo yokuxilonga kwi-Generalized Anxiety Disorder (GAD), kukho izikhalazo malunga nememori yokusebenza njengempawu yokuqonda yokuphazamiseka. Uphando lufumene ukungaqhelekanga kwimetabolism yobuchopho kwabo bane-GAD, abazama ukukhumbula kwimemori yokusebenza ngelixa bephantsi kweziphazamisi ezikhuthaza iimvakalelo.

Oku akumangalisi, njengoko i-basal ganglia isetyenziselwa ingqalelo kunye nokucoca iziphazamiso. Kubantu abanexhala ngokubanzi, isenzo sokukhathazeka siba yindlela yokuziphatha ezenzekelayo. Kukho ukungakwazi ukumisela ukuba yeyiphi inkxalabo efanele ukuqwalaselwa kwaye usoloko uxhalabile, kwanangezinto ezinokwenzeka ezingenakwenzeka. Ngaba ukuphuculwa kwemetabolism yobuchopho kule mimandla kuya kunceda ukunciphisa ezinye zeempawu ze-Generalized Anxiety Disorder (GAD)?

Owasetyhini Basal Ganglia Brain Anatomy

Oku kunokuthetha ukuba abantu abanengxaki banexesha elinzima lokuqonda iimeko ezixhalabisa ngokwenene ezivela kwizinto ezicaphukisayo. Kwangaxeshanye, i-amygdala yayiqhagamshelwe ngakumbi kwinethiwekhi yolawulo lwe-cortical efunyenwe ngaphambili ukuba isebenzise ulawulo lokuqonda kwimvakalelo.

https://med.stanford.edu/news/all-news/2009/12/brain-scans-show-distinctive-patterns-in-people-with-generalized-anxiety-disorder-in-stanford-study.html

Okubangel 'umdla kukuba, kwiingqondo zabantu abane-Generalized Anxiety Disorder (GAD), siphinde sibone imiba kunye nokudibanisa phakathi kwezakhiwo zengqondo.

Iingxaki ngoqhagamshelwano lwenzeka phakathi kwe-amygdala kunye nezinye izakhiwo zengqondo. Kwingqondo ephethwe yi-GAD, inonxibelelwano oluncinci kwiithagethi ezibonwa ngokubanzi kubuchopho obuqhelekileyo. Kwaye xa i-amygdala "yayidityaniswe ngaphezulu" kwezi ezinye izakhiwo zobuchopho, kwabonakala ngathi zinempembelelo apho kwaye njani ziqhagamshelwe kwezinye iindawo zobuchopho. Ezi ezinye izakhiwo zibonwa ukuba emva koko ziqhagamshelwe ngokungaqhelekanga kwiindawo zengqondo ezingabonwanga ukuba ziqhagamshelwe. Intsingiselo, uqhagamshelwano olungakumbi lwabonwa phakathi kweendawo ekungafanelanga ukuba zibekho. Ubuncinci hayi kwiingqondo ezisempilweni ezinonxibelelwano oluqhelekileyo.

Inqaku elibalulekileyo yayikukuba ummandla we-amygdala unonxibelelwano oluncinci kwinxalenye yengqondo enoxanduva lokuvavanya ukubaluleka kwe-stimulus. Kucingelwa ukuba le inokuba yiyo ebangela ukuba abantu be-GAD bangazi ukuba mababeke ntoni ngokubaluleka malunga neenkxalabo zabo. Kwaye ke abantu abane-GAD badla ngokuzikhathaza ngayo yonke into, ngokuchasene nesongelo okanye inkxalabo yokwenyani.

Ukutya kwe-ketogenic kunokunceda njani nge-hypometabolism kunye nokuba nengxaki kunye nokunxibelelana?

I-Hypometabolism kunye ne-keto

Izidlo ze-Ketogenic zisetyenziselwa ukuphucula i-metabolism yengqondo kwi-Alzheimer's Disease kunye nezinye izifo ze-neurological. Iphucula uvakalelo lwe-insulin kwingqondo yeeseli ezisakwazi ukusebenzisa i-glucose. Kwiindawo zengqondo ezingasasebenzisi i-glucose kunye ne-fuel ephambili, inika enye ifutha yee-ketones. Ii-ketones ziyakwazi ukwandisa ukusebenza kwe-mitochondria ekhoyo. Ezi mitochondria zizixhobo zamandla zeeseli ze-neuronal. Akunjalo kuphela ii-ketones ezinceda i-mitochondria yakho isebenze ngcono kodwa ii-ketones zinceda iiseli zakho zenze i-mitochondria eninzi. Nto leyo eyenza amandla amaninzi engqondo. Okwandisa imetabolism kwingqondo ngendlela enenzuzo.

I-Brain-Derived Neurotrophic Factor (BDNF) kunye ne-Keto

Enye inzuzo enamandla yokutya kwe-ketogenic kukukwazi kwabo ukulawula (ukwenza okungakumbi) into ebizwa ngokuba yi-Brain-Derived Neurotrophic Factor (BDNF). I-BDNF ivumela ingqondo ukuba ilungise kwaye ikhulise uxhulumaniso olutsha. Ukuba kukho iingxaki ngokunxibelelana kwengqondo, akukho ngqiqweni ukucinga ukuba ungenelelo olulawulayo lo mbandela luya kuba yinxalenye ebalulekileyo yokubuyisela? Ngaba ukutya kwe-ketogenic kusetyenziswe ngokubambisana ne-cognitive-behavioral therapy (CBT) eyenzelwe ukutshintsha iipatheni zokucinga ingabi yintlangano enamandla? Ukunikezelwa okwaneleyo kwe-BDNF kunokuba yinto efanelekileyo kuphela kunyango lwe-Generalized Anxiety Disorder (GAD).

Ukungalingani kwe-Neurotransmitter kubonwa kwi-Generalized Anxiety Disorder (GAD)

Kanye njengokuba kunjalo nakwezinye iziphazamiso zengqondo, asiboni kuphazamiseka kwi-neurotransmitter enye. Endaweni yoko sibona ukuphazamiseka kwibhalansi ethambileyo yenkqubo ye-neurotransmitter. Ezi ziquka ukunciphisa i-GABA, ukunyuka kwe-glutamate, kunye nokunciphisa kwi-serotonin. Kukwakho ukungasebenzi kakuhle kwe-neurotransmitter dopamine.

Ukunciphisa kwi-GABA ngokunyuka kwe-glutamate kubonakala kwezinye iingxaki zokuxhalaba, njengoko kuchazwe kule post blog.

Oku kungalingani kwe-neurotransmitter kaninzi kwenzeka ngenxa yokusingqongileyo apho zenziwa khona. Ingqondo enengxaki yokudumba kunye noxinzelelo lwe-oxidative, esiza kuxoxa ngayo kamva kwesi sithuba, ayisiyongqondo elungiselelwe ukwenza kunye nokusebenzisa ii-neurotransmitters ngempumelelo.

Ubuchopho obuphezulu ekudumbeni, nangasiphi na isizathu (kodwa kusenokwenzeka ukuba kungenxa yokutya iicarbohydrates ezicutshungulwayo kakhulu), kuya kubangela into ebizwa ngokuba yi-Tryptophan. I-Tryptophan yi-amino acid eyisandulela kwezinye ii-neurotransmitters. Xa ingqondo iphethwe kukudumba kuya kudala ngaphantsi (kwehlisela phantsi) i-neurotransmitter GABA. Kwaye endaweni yoko, iyakuthatha i-tryptophan kwaye yenze ngakumbi i-neurotransmitter enomdla eyaziwa ngokuba yi-glutamate. Eyona nto ngokwayo ayinakuba mbi, ngaphandle kokuba kufuneka sibe namanqanaba aneleyo e-GABA kunye ne-glutamate yethu ukugcina i-neurotransmitters yethu ibhalansi. Kwakhona, i-glutamate eninzi kakhulu yi-neurotoxic kwingqondo. Iyaguga ingqondo kwaye ibangele umonakalo. Ukubiwa kwe-tryptophan okwenzeka xa ingqondo iphantsi koxinzelelo kunokubangela ukuya kuthi ga kwi-100x ngaphezulu kwe-glutamate engqondweni kunamanqanaba aqhelekileyo.

Umsebenzi we-cell membrane ubalulekile ekugcineni ibhalansi ye-neurotransmitter. Umsebenzi we-cell membrane kwiiseli ze-neuronal uvumela ukudalwa kwee-neurotransmitters, ukuba zivutha ngokukhawuleza kangakanani, kwaye i-neurotransmitter ihlala ixesha elingakanani ukuze isetyenziswe ngaphakathi. ukucandeka kwe-synaptic. Oku kufanelekileyo kwabo bane-Generalized Anxiety Disorder (GAD) ngenxa yokuba ukuphinda kuthathwe i-Dopamine kwizakhiwo ezithile zengqondo (umzekelo, i-striatum) ibonakala iphantsi kakhulu kwizigulane ze-GAD kunolawulo olunempilo.

Ukutya kwe-ketogenic kunokunceda njani ngokungalingani kwe-neurotransmitter?

Ubukhulu becala ukutya kwe-ketogenic kunceda ngokungalingani kwe-neurotransmitter ngokunciphisa ukudumba, ukuze indawo ekwenziwa kuyo ibe yindawo enempilo yokwenza oko. Kodwa ukutya kwe-ketogenic kuye kwabonwa ukubuyisela ukusebenza kwe-neurotransmitter kunye ne-ion channel, enemiphumo enamandla kakhulu kwindlela i-neurotransmitters enokusebenza ngayo. Kwesi sithuba sincinci, sixoxe ngokubaluleka kokuphuculwa komsebenzi we-membrane yeseli.

Oko kuthetha ntoni kwingqondo yakho kukuba wonke umsebenzi wokwenza ibhalansi ye-neurotransmitter eyiyo awanelanga. Ingqondo yakho kusafuneka ikwazi ukusebenzisa ezo neurotransmitters ngendlela esebenzayo. Oko kuthetha ukukwazi ukugcina izondlo ezibalulekileyo (i-cofactors) ukwenzela ukuba ii-neurotransmitters zenziwe, zikwazi ukwaphula ezinye ii-neurotransmitters, kunye nokukwazi ukuvumela ii-neurotransmitters ukuba zixhonywe kwii-synapses ngexesha elifanelekileyo. Izidlo ze-Ketogenic zivumela le misebenzi ukuba ibuyiselwe kwaye ivumele ibhalansi ye-neurotransmitter ukuba yenzeke ngokuphucula ukusebenza kwe-neuronal. Kwaye ukuba kuphuculwe ukusebenza kwe-neuronal ukufezekisa konke oko akuvakali njengento ebalulekileyo ekujoliswe kuyo kunyango kwingxaki yokuxhalaba njenge-GAD, andiqinisekanga ukuba iya kuba yintoni!

Uxinzelelo lwe-Oxidative lubonwa kwi-Generalized Anxiety Disorder (GAD)

Sonke sivile igama elithi Oxidative Stress kodwa sinokungaqiniseki ukuba yintoni kwaye ithetha ntoni kumzimba wethu, ngaphandle kokuba "imbi" kwaye kufuneka siyiphephe. Uxinzelelo lwe-oxidative luyenzeka. Ukuba uyaphila ngoko uxinzelelo lwe-oxidative luya kwenzeka ngenxa yokuba umzimba wakho wenza iinkqubo ezininzi zebhayoloji ezenza izinto umzimba wakho ekufuneka ujongane nazo. Yiloo nto kanye eyenzekayo ngaphakathi. Oko akujongi nefuthe lokuvezwa kokusingqongileyo ngaphandle kwemizimba yethu (umzekelo, iikhemikhali, ungcoliseko, indlela yokuphila).

Ukuphila ngendlela enempilo kukuvumela ukuba ulawule umthamo woxinzelelo lwe-oxidative umzimba wakho ekufuneka uhambe kuwo kwaye uya kwenza nezinto ezinceda ukuphucula amandla akho okujongana nento eyenzekayo. Umthambo ngumzekelo omhle woku. Iphakamisa amandla ethu okwenza i-antioxidants kwiindlela ezikhoyo emizimbeni yethu, njenge-glutathione.

Xa sijonga abo bane-Generalized Anxiety Disorder (GAD) sibona ukuba kukho uxinzelelo olukhulu lwe-oxidative kule ndawo.

Izigulana zengxaki yoxinzelelo ngokubanzi zinamanqanaba aphezulu esalathiso soxinzelelo lwe-oxidative.

U-Ercan, et al., (2017); https://doi.org/10.1016/j.ajp.2016.10.008

Basazama ukukhupha ukuba uxinzelelo lwe-oxidative lubangela i-GAD, okanye ukuba i-GAD, ngenxa yoxinzelelo olubangelwa ngumzimba ngenxa yokukhathazeka ngokugqithiseleyo, ibangela uxinzelelo lwe-oxidative. Kwaye ndingaphikisa ukuba ayinamsebenzi. Masiyicinge loo nxalenye kamva kwaye senze okusemandleni ethu ukunciphisa uxinzelelo lwe-oxidative. Masibe yinto ekujoliswe kuyo yongenelelo lwebhayoloji kwaye masenze konke okusemandleni ethu ukunciphisa ukukhathazeka kwiingcinga zethu ngeCognitive-Behavioral Therapy (CBT).

Ukuguqulwa kwe-oxidative kwiiprotheyini ngokwenene kucetywayo njengento enokubakho ekuqaleni kunye nokuqhubela phambili kweengxaki ezininzi zengqondo, kubandakanya ixhala kunye noxinzelelo.

Fedoce, et al., (2018), https://doi.org/10.1080/10715762.2018.1475733

Ukungakwazi ukujongana nala manqanaba oxinzelelo lwe-oxidative kwingqondo kutshabalalisa i-neurons. Kuncwadi, ngokwenene bayibiza ngokuba "yi-neuronal trauma egqithisileyo" kwaye njengoko unokucinga, ezi seli zokwenzakala zophukile kwaye azikwazi ukwenza yonke imisebenzi ekufuneka yenze ukugcina ingqondo yakho isebenza. Abayi kwenza i-neurotransmitters kakuhle, abayi kuba ne-neuronal membranes esebenzayo, kwaye abayi kukwazi ukugcina izondlo ezifunekayo ukuze benze ukugcinwa kweeseli okanye ukwenza ii-enzyme ezifunekayo ezilawula ezo neurotransmitters. Kutheni sinokulindela ukuba sinokuphosa i-serotonin reuptake inhibitor (SSRI) kwinkqubo enzima njengonyango? Phosa zonke ii-neurotransmitters ozifunayo apho kodwa ukuba ii-membrane kunye noomatshini baphangisiwe ayizukusebenza. Iiseli ze-Neuronal zonakaliswa kakhulu kwaye zitshatyalaliswe ngoxinzelelo lwe-oxidative. Thetha malunga ne-band-aid mentality kwisigulo sengqondo. Kutheni singabancedi nje abantu ukulungisa iisynapse?

Ukutya kwe-ketogenic kunokunciphisa njani uxinzelelo lwe-oxidative?

Izidlo ze-Ketogenic zigqwesileyo kuxinzelelo lwe-oxidative. Oku akuyontelekelelo kum. Kwaye oku akusiyo inkcazo eyenziwe kuphela ngenxa yezifundo zezilwanyana. Obu bubomi bokwenyani kunye nesiphumo esinamandla esibonwa ebantwini, kwizifundo nabantu bokwenyani.

I-cerebral metabolism yeetoni ibonakaliswe ukuphucula amandla eselula, ukwandisa umsebenzi we-glutathione peroxidase,15 ukunciphisa ukufa kweeseli16 kwaye unamandla okuchasa ukudumba kunye ne-antioxidant kuzo zombini i-In vitro kwaye kwi vivo imizekelo.17-20

https://doi.org/10.1177/0271678X15610584

Enye yezinto endizithandayo ukuthetha ngayo yi-glutathione. Kwaye hayi uhlobo oluthathayo kwipilisi oyinikwa ngugqirha wakho we-naturopath okanye amayeza asebenzayo. I-glutathione yomlomo ayisetyenziswanga ngumzimba kakuhle kwaye iyabiza. Ngamanye amaxesha baya kukunika ii-precursors ngendlela yeevithamini kunye neeminerali, ngethemba lokuba umzimba wakho uya kwenza ngaphezulu kwe-glutathione yayo, eyona nto ingcono kwaye ndiyivuma ngokupheleleyo. Kodwa akukho nto iya kulawula (yenza ngaphezulu) imveliso ye-endogenous (eyenziwe ngumzimba wakho) i-glutathione efana ne-ketogenic yokutya eyenziwe kakuhle (intsingiselo yezondlo-ezixineneyo).

Ke ukunyanga uxinzelelo lwe-oxidative kwingqondo ye-GAD ngokutya kwe-ketogenic akufuneki kube sisimo esinjalo soguquko kunye nempikiswano. Kwaye ngokuqinisekileyo akunjalo. Njengoko ubona, kukho iindlela esele zichongiwe kunye neziphumo ezicacileyo zokusetyenziswa kwayo kwiinkqubo ze-pathological ezisisiseko esizichongileyo ngophando lwezenzululwazi.

Ukuvuvukala kubonwa kwi-Generalized Anxiety Disorder (GAD)

Makhe sixoxe nge-neuroinflammation. I-Neuroinflammation ivela ngenxa yezizathu ezininzi ezahlukeneyo. Iimpembelelo zengqondo, njengokutolika kwethu kwimeko, kunokubangela ukuvuvukala. Into esiyidlayo inokubangela ukuvuvukala, nokuba ngenxa yokuba amanqanaba eshukela egazi aphezulu kakhulu okanye sinokusabela komzimba kukutya okuthile. Ukudumba kunokwenzeka ngenxa yokuba kukho into eye yawela umqobo wegazi-ubuchopho obungamele ukuba nayo. Zonke ezi zinto zibangela ukusabela kwamajoni omzimba. Kwaye ubuchopho bethu bunempendulo yabo yomzimba kwaye baphendula ngento ebizwa ngokuba yi-microglia.

I-Microglia izama ukulungisa oko kungahambi kakuhle ngokukhupha iikhemikhali ezivuthayo. Olunye uhlobo lweekhemikhali ezivuthayo ezikhutshwa yi-microglia yi-cytokines. Kukho iintlobo ezahlukeneyo zeecytokines. Kwaye banokulinganiswa ngeemvavanyo zegazi le-serum. Ugqirha wakho usenokuba uku-odole i-CRP okanye uvavanyo lwe-CRP olunovakalelo oluphezulu ukwenzela wena. Olu luphawu lokudumba. Kodwa kubalulekile ukuqonda ukuba kukho ezininzi iintlobo ezahlukeneyo ze-cytokines ezandisa ukuvuvukala. Oku kunokwenza uphando lube nzima. Ezinye iintlobo zeecytokines zinokufundwa ngaphezu kwezinye. Abanye baya kufundwa kwezinye iindawo kodwa hayi kwabanye. Asinawo umfanekiso omhle ocacileyo. Ngokukodwa kwi-Generalized Anxiety Disorder (GAD) yabemi

Ukuvuvukala kunye nokunxulumana nabantu abaphethwe yi-GAD kuncinci kuyo yonke indawo kuncwadi. Ezinye izifundo zifumene abantu abane-GAD ukuba babe namanqaku aphezulu okuvuvukala. Oku akumangalisi ukuba bathanda ukuba noxinzelelo lwe-oxidative. Abanye abantu abane-GAD kunye namanqaku athile ofuzo babonwa benokuvuvukala okungaphezulu kunabanye. Oku kwakhona, akumangalisi. Indlela umzimba wethu obonakalisa ngayo isifo phantsi kweemeko ezifanelekileyo ze-epigenetic ngokuqinisekileyo iya kuba necandelo lezofuzo.

Kodwa amakishi aphezulu okuvuvukala awasoloko ebonwa kuncwadi lwabantu abane-GAD. Ngapha koko, abanye baye babonisa ukuba abantu abane-GAD abanazo iimpawu eziphezulu zokudumba. Kodwa ezinye iiphononongo zihlekisa umahluko phakathi kwabantu abane-GAD. Umzekelo, abasetyhini abaphuhlise i-GAD kamva ebomini banamanqaku aphezulu okudumba kunalawo aphuhlisayo kwangethuba ebomini. Kwaye asinakubonakala sifumanisa ukuba ukuvuvukala kunendima ebangelayo kwi-etiology (ukudala) ye-GAD.

Ngoko ke ndingathetha oku. Ukuba unayo kuphela I-Generalized Anxiety Disorder (GAD), kwaye akukho zimpawu zokudakumba kwe-comorbid, okanye i-comorbid Panic Disorder (i-DOES ibona amanqaku aphezulu okuvuvukala), indima yokutya kwe-ketogenic kwi-inflammation ayinakuba nomdla kuwe ekubuyiseleni kwakho. Njengomcebisi wezempilo yengqondo, nangona kunjalo, andiziboni izigulana ezininzi ezine-GAD ecocekileyo ngaphandle kwazo naziphi na ii-comorbidities. Ke ukudumba kusenokungabi ngumba kwi-GAD, okanye inokuba ngumba kwaye akukho zifundo zaneleyo ezibandakanya i-GAD njengenxalenye yophando kunye nezinye izifo kunye nesi sihloko.

Kodwa nje ukuba une-GAD kwaye unengxaki yokuxilongwa kabini kunye nezinye izigulo zengqondo, ndiya kuxoxa ngesiphumo sokutya kwe-ketogenic ekudumbeni.

Ukutya kwe-ketogenic kulwa njani nokuvuvukala?

Ukutya kwe-Ketogenic kungenelelo lwe-metabolic. I-metabolism yobuchopho ineempembelelo ngqo ekusebenzeni komzimba kwingqondo. Kwaye njengoko sisazi ngokufunda le post blog, ukusebenza komzimba kwingqondo kuneziphumo ezithe ngqo ekudumbeni. Amafutha aphezulu, i-low-carbohydrates ketogenic diet yenza ii-ketones, ezinciphisa ukusebenza kwe-microglial kunye ne-pro-inflammatory cytokines. I-Ketones ngokwenene ingumzimba obonisayo, ochaphazela ukubonakaliswa kofuzo, onokuthi ube neempembelelo ezintle kwiindlela ezilungelelanisa ukuvuvukala. Ukuba ufuna ukuntywila nzulu kancinci kwindlela izidlo ze-ketogenic ezilwa nokudumba kukho elona nqaku libalaseleyo. Apha.

Ezinye iindlela ukutya kwe ketogenic kunokunceda ekunciphiseni ukudumba kubandakanya ukuguqulwa kwegut microbiota. Sisafunda malunga nazo zonke iindlela zokutya ze-ketogenic zinceda ukulwa nokuvuvukala. Kodwa kungakhathaliseki ukuba ukhetha ukutya kwe-ketogenic ukunceda ukunyanga i-Generalized Anxiety Disorder okanye esinye isifo sengqondo okanye ukuphazamiseka kwengqondo, kubalulekile ukuqonda ukuba i-neuroinflammation inetyhefu kwiingqondo. Iqhekeza umqobo wegazi-ubuchopho owenziwe ngumzimba wakho ukuzama nokukhusela ingqondo yakho. Iyonakalisa i-neuronal membranes kwaye yenza kube nzima kwiiseli ze-neuronal ukunxibelelana enye kwenye kwaye zisebenze ngokwazo. Kwaye ekugqibeleni kukhokelela ekufeni kweeseli. Kwaye izidlo ze-ketogenic zibonise iindlela ezichanekileyo ezibonelela nge-neuroprotective kunye ne-anti-inflammatory benefits kubantu (kungekhona nje izifundo zezilwanyana).

Ekubeni ungumntu, ndingenisa oku ukuze uqwalaselwe ekuvavanyeni zonke iinketho ezahlukeneyo onazo zokuziva ngcono.

isiphelo


Ukutya kwe-ketogenic kuyindlela efanelekileyo kulabo abane-Generalized Anxiety Disorder (GAD) njengendlela yonyango yokuqwalasela. Iimpembelelo zayo ekuphuculeni okanye ekuphatheni i-hypometabolism yobuchopho, ukulinganisa i-neurotransmitters kunye nokuphucula umsebenzi we-neuronal, kunye nokukhusela ingqondo kwixinzelelo lwe-oxidative kunye ne-neuroinflammation zonke iindlela ezisekelwe kwiincwadi zesayensi. Ezi zizinto ezibonwa kubantu abaphethwe yiGeneralized Anxiety Disorder (GAD). Ukutya kwe-ketogenic kunokuba lukhetho olulungileyo njengonyango oluphambili okanye olongezelelweyo olubandakanya unyango lwengqondo kunye./okanye amayeza. Isenokugqalwa njengonyango kwabo bafuna ukuphepha amayeza, kwabo bamayeza angasasebenzi kakuhle, okanye abangathanda ukuthatha amayeza amancinci ngelinge lokunciphisa iziphumo ebezingalindelekanga.

Kuba unelungelo lokwazi zonke iindlela onokuziva ungcono ngazo.

Nceda wabelane ngale kunye nezinye izithuba zeblogi endizibhalayo ukuze ukwazi ukundinceda ukwabelana ngolu lwazi. Ukuba ubona enye yeeposti zebhlog yam Twilley, Facebook, okanye Twitter nceda wabelane ngoko ukufumeneyo. Ukuba ungathanda ukwazi ngakumbi ngam kunye nento endiyenzayo unokufunda oko Apha. Ukuba ungathanda ukufunda ngakumbi malunga nokusebenza nam kwifomati yenkqubo ye-intanethi ungafumana olu lwazi apha:

Njengale nto uyifundayo kwibhlog? Ngaba uyafuna ukufunda malunga neewebinars ezizayo, iikhosi, kunye nokubonelela ngenkxaso kunye nokusebenza nam kwiinjongo zakho zempilo? Bhalisa!


Ucaphulo

Bandelow B. (2020) yangoku kunye neNoveli Psychopharmacological Drugs for Anxiety Disorders. Ku: Kim YK. (eds) Iziphazamiso zokuxhalaba. Ukuqhubela phambili kwi-Experimental Medicine kunye ne-Biology, vol 1191. Springer, Singapore. https://doi.org/10.1007/978-981-32-9705-0_19

Berk, M., Williams, LJ, Jacka, FN, O'Neil, A., Pasco, JA, Moylan, S., … & Maes, M. (2013). Ngoko ukudakumba sisifo sokuvuvukala, kodwa ukuvuvukala kuvela phi? Amayeza e-BMC11(1), 1-16. https://pubmed.ncbi.nlm.nih.gov/24228900/

Brawman-Mintzer, O., & Lydiard, RB (1997). Isiseko sebhayoloji sengxaki yokukhathazeka ngokubanzi. Ijenali yonyango lweengqondo58(3), 16-26. https://www.psychiatrist.com/wp-content/uploads/2021/02/11209_biological-basis-generalized-anxiety-disorder.pdf

Costello, H., Gould, RL, Abrol, E., & Howard, R. (2019). Uphononongo olucwangcisiweyo kunye nohlalutyo lwe-meta lombutho phakathi kwe-cytokines evuthayo kunye noxinzelelo oluqhelekileyo. I-BMJ ivuliwe9(7), e027925. https://bmjopen.bmj.com/content/9/7/e027925

Ercan, AC, Bahceci, B., Polat, S., Cenker, OC, Bahceci, I., Koroglu, A., ... & Hocaoglu, C. (2017). Isimo se-Oxidative kunye nemisebenzi ye-prolidase kwingxaki yokukhathazeka ngokubanzi. Ijenali yaseAsia yezengqondo25, 118-122. https://www.sciencedirect.com/science/article/abs/pii/S1876201816302477

Etkin, A., Prater, KE, Schatzberg, AF, Menon, V., & Greicius, MD (2009). Ukuphazamiseka kwe-amygdalar subregion uqhagamshelwano olusebenzayo kunye nobungqina benethiwekhi yembuyekezo kwingxaki yokukhathazeka ngokubanzi. Oovimba bengqondo jikelele66(12), 1361-1372. https://findlab.stanford.edu/Publications/Etkin%20et%20al%202009%20-%20JAMA%20Psychiatry.pdf

Fedoce, ADG, Ferreira, F., Bota, RG, Bonet-Costa, V., Sun, PY, & Davies, KJ (2018). Indima yoxinzelelo lwe-oxidative kwingxaki yokuxhalaba: imbangela okanye isiphumo? Uphando olukhululekileyo lwasimahla52(7), 737-750. https://www.tandfonline.com/doi/abs/10.1080/10715762.2018.1475733

Field, R., Field, T., Pourkazemi, F., & Rooney, K. (2021). Ukutya kwe-Ketogenic kunye nenkqubo ye-nervous: ukuphononongwa kwe-scoping yeziphumo ze-neurological ezivela kwi-ketosis yesondlo kwizifundo zezilwanyana. Uphononongo loPhando lweZondlo, 1-39.

Foerde, K., & Shohamy, D. (2011). Indima ye-basal ganglia ekufundeni nakwinkumbulo: ukuqonda kwisifo sika-Parkinson. I-Neurobiology yokufunda kunye nenkumbulo96(4), 624-636. https://doi.org/10.1016/j.nlm.2011.08.006

Gano, LB, Patel, M., & Rho, JM (2014). Ukutya kwe-Ketogenic, i-mitochondria, kunye nezifo ze-neurological. Ijenali yophando lwe lipid55(11), 2211-2228. https://pubmed.ncbi.nlm.nih.gov/24847102/

Greco, T., Glenn, TC, Hovda, DA, & Prins, ML (2016). Ukutya kwe-Ketogenic kunciphisa uxinzelelo lwe-oxidative kunye nokuphucula umsebenzi onzima wokuphefumla we-mitochondrial. Ijenali yokuhamba kwegazi leCerebral kunye neMetabolism36(9), 1603-1613. https://doi.org/10.1177/0271678X15610584

Hashimoto, H., Monserratt, L., Nguyen, P., Feil, D., Harwood, D., Mandelkern, MA, & Sultzer, DL (2006). Ukuxhalaba kunye nommandla we-cortical glucose metabolism kwizigulana ezinesifo se-Alzheimer. Ijenali ye-neuropsychiatry kunye neeklinikhi ze-neuroscience18(4), 521-528. https://neuro.psychiatryonline.org/doi/full/10.1176/jnp.2006.18.4.521

Koh, S., Dupuis, N., & Auvin, S. (2020). Ukutya kwe-Ketogenic kunye ne-neuroinflammation. Uphando lweSithuthwane, 106454. https://doi.org/10.1016/j.eplepsyres.2020.106454

I-Maalouf, M, Sullivan, PG, Davis, L. Ketones inqanda ukuveliswa kwe-mitochondrial yokuveliswa kweentlobo ze-oksijini esebenzayo emva kwe-glutamate excitotoxicity ngokunyusa i-NADH oxidation. I-Neuroscience 2007; 145: 256–264. https://doi.org/10.1016/j.neuroscience.2006.11.065

UMartin, EI, Ressler, KJ, Binder, E., & Nemeroff, CB (2009). I-neurobiology yokuphazamiseka kokuxhalaba: ukucinga kwengqondo, imfuzo, kunye ne-psychoneuroendocrinology. Iiklinikhi zeNgqondo zaseMntla Melika32(3), 549-575. https://doi.org/10.1016/j.psc.2009.05.004

Melaragno A., Spera V., Bui E. (2020) Psychopharmacology of Anxiety Disorders. Ku: Bui E., Charney M., Baker A. (eds) Incwadi yeClinical Handbook of Anxiety Disorders. I-Clinical Psychiatry yangoku. Humana, Cham. https://doi.org/10.1007/978-3-030-30687-8_13

Inyanga, CM, Sundaram, T., Choi, NG, & Jeong, GW (2016). Ukungasebenzi kakuhle kwememori ehambelana nokusilela kokusebenza kwengqondo kunye notshintsho lwemetabolism yeselula kwizigulana ezinoxinzelelo oluqhelekileyo. UPhando lwezePsychational: Neuroimaging254, 137-144. https://www.sciencedirect.com/science/article/abs/pii/S0925492715300901

Nemeroff, CB (2003). Indima ye-GABA kwi-pathophysiology kunye nonyango lweengxaki zokukhathazeka. Ibhulethi yePsychopharmacology37(4), 133-146. https://europepmc.org/article/med/15131523

Norwitz, NG, & Naidoo, U. (2021). Isondlo njengoNyango lweMetabolic yeNxwala. Imida kunyango lwengqondo12, 105. https://www.frontiersin.org/articles/10.3389/fpsyt.2021.598119/full?fbclid=IwAR0Oz-a2xkDLSjVq3svdxl29l-AhPPi1fCO7D43gB3p6n9YttUqgtH-FxKs

I-Paoli A, i-Cenci L, i-Pompei P, i-Sahin N, i-Bianco A, i-Neri M, i-Caprio M, i-Moro T. Imiphumo yeeNyanga ezimbini ze-Carbohydrate ephantsi kakhulu ye-Ketogenic Diet kwi-Body Composition, amandla e-Muscle, i-Muscle Area, kunye neeParameters zeGazi kwi-Competitive Natural. Abakhi Bomzimba. Amanzi. Ngo-2021; 13 (2): 374. https://doi.org/10.3390/nu13020374

Peruzzotti-Jametti, L., Willis, CM, Hamel, R., Krzak, G., & Pluchino, S. (2021). Ukulawulwa kweMetabolic ye-Smoldering Neuroinflammation. Imida kwi-immunology12, 705920. https://doi.org/10.3389/fimmu.2021.705920

Pinto, A., Bonucci, A., Maggi, E., Corsi, M., & Businaro, R. (2018). I-Anti-Oxidant kunye ne-Anti-Inflammatory Activity ye-Ketogenic Diet: Iimbono ezintsha ze-Neuroprotection kwi-Alzheimer's Disease. Ii-antioxidants (i-Basel, Switzerland)7(5), 63. https://doi.org/10.3390/antiox7050063

Ring, HA, & Serra-Mestres, J. (2002). I-Neuropsychiatry ye-basal ganglia. Ijenali ye-Neurology, Neurosurgery & Psychiatry72(1), 12-21. https://jnnp.bmj.com/content/72/1/12#ref-16

Santoft, F., Hedman-Lagerlöf, E., Salomonsson, S., Lindsäter, E., Ljótsson, B., Kecklund, G., … & Andreasson, A. (2020). I-cytokines ezivuthayo kwizigulana ezineengxaki zengqondo eziqhelekileyo eziphathwa ngonyango lokuziphatha kwengqondo. Ubuchopho, iNdlela yokuZiphatha, kunye noKhuseleko-Impilo3, 100045. https://doi.org/10.1016/j.bbih.2020.100045

Tallon, K., Koerner, N., & Yang, L. (2016). Inkumbulo yokusebenza kwingxaki yokuxhalaba ngokubanzi: Iziphumo zenkxalabo yomlomo kunye nesekwe kumfanekiso kunye nokunxulumana neenkqubo zokuqonda kunye neemvakalelo. Ijenali ye-Experimental Psychopathology7(1), 72-94.

Uchiyama, T., Ikeuchi, T., Ouchi, Y., Sakamoto, M., Kasuga, K., Shiga, A., … & Ohashi, T. (2008). Iimpawu ezibalaseleyo zengqondo kunye ne-glucose hypometabolism kwintsapho enokuphindaphinda kwe-SNCA. Neurology71(16), 1289-1291. https://n.neurology.org/content/71/16/1289

Vogelzangs, N., Beekman, ATF, De Jonge, P., & Penninx, BWJH (2013). Ukuphazamiseka kokuxhalaba kunye nokuvuvukala kwiqela elikhulu labantu abadala. Uguqulelo lwengqondo3(4), e249-e249. https://www.nature.com/articles/tp201327

Wagner, EYN, Strippoli, MPF, Ajdacic-Gross, V., Gholam-Rezaee, M., Glaus, J., Vandeleur, C., … & von Känel, R. (2020). Ukuphazamiseka kokuxhalaba okuqhelekileyo kuhambelana nokuncitshiswa kwamanqanaba e-interleukin-6 kunye ne-adiponectin phakathi kwabantu abavela kuluntu. Ijenali yeengxaki ze-affective270, 114-117. https://pubmed.ncbi.nlm.nih.gov/32339100/

Williams, EM, Hyer, JM, Viswanathan, R., Faith, TD, Egede, L., Oates, JC, & Marshall, GD (2017). Ukulinganisela kwe-Cytokine kunye nokungenelela kokuziphatha; iziphumo ezivela kwiprojekthi yePeer Approaches to Lupus Self-Management (PALS) . I-immunology yomntu78(9), 574-581. https://pubmed.ncbi.nlm.nih.gov/28716698/