Ngaba iingxaki zakho zememori ziqhelekileyo? Ngaba kungenxa yokuba ukhula? Ngaba azikho iingxaki zokufumana igama elichanekileyo, ukuphulukana nomzila wakho wengcinga, kunye nokulibala izinto njengenxalenye yokwaluphala? Ngaba lixesha eliphezulu? Hayi ngokukhawuleza. Siziqhelanisa ezi zinto kuba ziqhelekile. Siyaziqinisekisa thina nabanye ukuba akukho nto inkulu. Siyayihleka ngokuvakalayo kodwa sisoyika kwaye singekho embindini. Eli yayingelonqanaba lethu lesiqhelo lokusebenza kwiminyaka nje eli-10 eyadlulayo, akunjalo?
Kwaye oku ayisiyonto nje "yokukhula" into. Abantu abancinci abaneminyaka engama-30 banokuqala ukuba nokukhubazeka okubonakalayo ekusebenzeni kwengqondo, okubandakanya iingxaki zememori yexesha elifutshane. Olu luphawu olusisilumkiso ekungafuneki luncitshiswe okanye lungahoywa.
Ukuphazamiseka kwengqondo enobumnene
Ukukhubazeka okuPhakamileyo kwengqondo (MCI) kunokuthi okanye kungabi ngumanduleli weSifo se-Alzheimer okanye ezinye iintlobo ze-dementia. Ukuphazamiseka okuPhakamileyo kwengqondo (MCI) akusoloko kuqhubela phambili kwiindlela ezahlukeneyo zokuvalelwa. Iingxaki zememori zinokwenzeka kwaye ukuqhubela phambili kobunzulu kunokuyeka. Kodwa iimpawu zokuncipha kwengqondo kweli nqanaba kunokubangela imiba ekusebenzeni kunye nakwinqanaba elithile lokuphila kwansuku zonke okanye ubudlelwane. Iingxaki zexesha elifutshane zenkumbulo zinokuphazamisa ukusebenza kwaye ubuncinci zijongele phantsi ukuzithemba komntu. Iimpawu ze-MCI zinokubandakanya oku kulandelayo:
- Ukulibala izinto rhoqo, kuquka iziganeko ezibalulekileyo ezifana namadinga okanye izicwangciso zentlalo
- Ukulibala okwenzeka ezincwadini okanye kwiimuvi, okanye kwanaloo nto yayithethwa encokweni
- Ukuziva uphantsi ekwenzeni izigqibo
- Ubunzima bokucwangcisa amanyathelo okuphumeza umsebenzi okanye imiyalelo yokuqonda
- Uqala ukuba nengxaki yokufumana indlela yakho kwiindawo eziqhelekileyo
- Ukungxama ngakumbi kunye nokuqala ukubonisa ukugweba okungalunganga
- Amagama-okanye iingxaki zokufumana amagama (ezona ziphawuleka kakhulu kusapho okanye kwizinxulumani ezisondeleyo)
- Ukungakwazi ukukhumbula amagama xa uziswa kubantu abatsha
- Imiba yokusebenza kwintlalontle kunye neesetingi zomsebenzi (iphawuleka kwabanye)
- Ukufunda isicatshulwa kunye nokugcina imathiriyeli encinci
- Ukulahlekelwa okanye ukubeka kwindawo engafanelekanga izinto ezibalulekileyo
- Ukuhla kwisakhono sokucwangcisa okanye ukulungelelanisa
- Udinga ukwenza iinkqubo ezintsha zokujongana neengxaki zememori
Kukangaphi evekini oku kusenzeka? Kangaphi ngemini? Uqaphela ntoni ukuba uqala ukuyiphepha ngenxa yokuba umthwalo wengqondo wale mi sebenzi uyadinisa okanye uyarhafisa? Ngaba ufunda kancinci ngoku? Ngaba ukhetha iimuvi ezilula oza kuzibukela onokuthi uzilandele? Ngaba uyabakhuthaza abanye ukuba benze izigqibo ukuze unganyanzelekanga? Zeziphi iindlela onazo zokufihla ukuba unengxaki yenkumbulo?
Ukuba uye wakhokelwa ukuba ukholelwe ukuba le yinxalenye eqhelekileyo yokuguga, kuya kuqondakala ukuba urhoxile kule nto yenzekayo. Kodwa oku asikokwaluphala okuqhelekileyo. Kwaye njengoko uza kubona njengoko ufunda ngakumbi, kukho ungenelelo lwendlela yokuphila enamandla ekhoyo ukunyanga iMild Cognitive Impairment kunye ne-Early Stage Alzheimer's Disease.
Isigaba sokuqala se-Alzheimer's Disease
Ngamanye amaxesha i-MCI iqhubela phambili kwi-Early Stage Alzheimer's Disease okanye enye i-dementia. Malunga ne-10 ukuya kuma-20%. Kwingxelo yophononongo iphezulu njenge-23% yenkqubela phambili ukusuka kwi-MCI ukuya kwi-dementia kwiminyaka emi-3. Ngoko ke ukuba unayo nayiphi na impawu ze-MCI kubalulekile ukuba uthathe ngokungqongqo Iimpawu ze-Alzheimer's Disease, uhlobo oluthile lwe-dementia luqukiwe ngezantsi. Ibandakanya zonke iimpawu ze-MCI kunye nobunzima obongezelelweyo kwimisebenzi yokuqonda kubandakanya:
- Inkumbulo encitshisiweyo yembali yomntu
- Ukunciphisa ukukwazi ukukhumbula iziganeko zamva nje
- Ukungakwazi ukwenza umngeni wokubala ngengqondo (umzekelo, ukubala ubuya umva ukusuka kwi-100 ngothotho lwesi-7)
- Ukuhla kwamandla okwenza imisebenzi enzima (umzekelo, ukuthenga, ukucwangcisa isidlo seendwendwe, ukuhlawula amatyala kunye/okanye ukulawula imali)
- Isigulana sinokubonakala sithobile kwaye sihoxisiwe, ngakumbi kwiimeko zentlalo okanye umngeni wengqondo (echongwe ngumntu omaziyo)
Kutheni oku kwenzeka?
Kukho izizathu ezininzi zokuphuhliswa kwe-Alzheimer's Disease. Uninzi lweSifo se-Alzheimer sivela kwimiba yokuphila. Abantu abaninzi abane-Alzheimer's, kwanabo banemizila yofuzo kuyo kwaye bakwizigaba zokuqala ukuya kwimodareyitha banokuhlehlisa okanye bacothise ukuqhubeka kwabo besebenzisa ukutya okune-ketogenic kunye nokuxhaswa kwento ebizwa ngokuba zii-exogenous ketones.
Kwabanye abantu, njengoko ingqondo ikhula, ayikwazi ukusebenzisa i-glucose yamandla. Isifo se-Alzheimer sibizwa ngokuba yi-Type III Diabetes ngenxa yesi sizathu. Ukungakwazi ukusebenzisa i-glucose yepetroli ngokuqhubekayo kubangela ingxaki yamandla eyandisa i-neuroinflammation. Abantu abatshintshela kwindlela eyenziwe kakuhle (funda i-nutrient dense kunye ne-oyile yembewu engaxutywanga) ukutya kwe-ketogenic kuvumela ubuchopho babo ukuba buqhube kwii-ketones. Eli futhe lilolunye lidlula ukuxhathisa kwe-insulin okuphuhlileyo kwingqondo eyenze ukuba kungenzeki ukuba iiseli zengqondo zisebenzise iswekile ukwenza amafutha.
Ukutya kwe-ketogenic kungenelelo lwamanqanaba amaninzi kwingqondo
Asinalo iyeza loxubo-mayeza elichaphazela yonke le misebenzi ibalulekileyo yobuchopho ngaxeshanye!
Ezi ketones azikho nje amafutha. Banceda ngokwenene ukuphilisa ingqondo. I-Ketones idala iimeko zento ebizwa ngokuba yi-brain-derived neurotrophic factor (BDNF) enamandla okwenza utshintsho kwingqondo njengokudibanisa ngakumbi phakathi kwe-synapses. Balawula (ukwenza ngaphezulu) okunamandla okungapheliyo (okuvela emzimbeni, kungangenisi) i-antioxidants njenge-glutathione. IiKetones ZINCIPHISA NGOKUBALULEKILEYO i-neuroinflammation. Banceda ukulungelelanisa i-neurotransmitters ngendlela efanelekileyo. Bade benze ukuba ii-neurons zenze ngcono kwinqanaba le-membrane kwaye zenze amandla amaninzi kwi-neurons ngokunyusa inani "leebhetri zeseli" ezibizwa ngokuba yi-mitochondria.
Ukutya kwe-ketogenic kufuneka kuqulunqwe kakuhle. Intsingiselo yezondlo-ezixineneyo, ngaphandle kweoli yembewu ye-neuroinflammatory kunye namafutha amaninzi anempilo. Kufuneka bafumane iprotheyini eyaneleyo yokugcina ubunzima bezihlunu. Abanye abantu banokudinga ukusebenzisa izongezelelo ze-ketone ukunyusa umthamo we-ketone fuel ekhoyo ukuphilisa kunye nokusebenza kwengqondo. Kodwa hayi rhoqo. Yiyo loo nto kuluncedo ukubona ingcali yezokutya okanye enye ingcali, njengam, ukunceda ukuqulunqa kunye nokunceda ngenguquko kolu kutya.
Kutheni le nto ndiza kuyitshintsha indlela enditya ngayo endaweni yokuthatha umyalelo kagqirha?
Ngenxa yokuba eyona nto iphambili kukuba kuyo yonke imashumi eminyaka i-Pharma isebenza ngolu hlobo oluthile lwemeko ye-neurological, iziphumo ziye zaba yinto engafanelekanga. Asinaso nje isigunyaziso esisebenza kwi-Alzheimer's ngayo nayiphi na indlela enentsingiselo ebuyisela umva okanye eyeka ukuqhubela phambili. Akukho ngenelelo oya kuzama kwi-MCI okanye i-Alzheimer's Disease enamandla njenge-Ketogenic Diet. Kwaye ngokuqinisekileyo iyabutshintsha ubomi babantu abaneengxaki ze-neurocognitive ezifana nezi zichazwe ngasentla. Ndiyibona ngalo lonke ixesha. Abantu bathi banengqondo ababenayo kwiminyaka eyi-10 eyadlulayo. Bathatha ngakumbi emsebenzini nasekhaya kunye nobudlelwane, kuba ingqondo yabo isebenza ngcono kwaye bafuna kwaye bazive ngathi. Ndikhe ndanomntu oneMCI phakathi kweminyaka engama-40 ogqiba abuyele esikolweni.
Ngaba oku kusekwe kwisayensi? Okanye olunye unyango oluphambeneyo?
Ubungqina beklinikhi kunye ne-preclinical bukhona ukuxhasa ukusetyenziswa kwezidlo ze-ketogenic kwi-Mild Cognitive Decline kunye ne-Alzheimer's Disease. Ulingo lwezonyango luyenzeka ngoku. Ngokuqinisekileyo isekwe kwisayensi.
Izifundo ezininzi zangaphambi kweklinikhi ziqinisekisile inzuzo ye-ketosis kwi-cognition kunye nokuvuvukala kwenkqubo. Ngenxa yogxininiso oluhlaziyiweyo kwi-neuroinflammation njengegalelo le-pathogenic ekunciphiseni kwengqondo, kunye nokuncipha kokuvuvukala kwenkqubo okubonwa ngokutya kwe-ketogenic, kuyacaca ukuba oku kutya kunokulibazisa, kuphucule, okanye kuthintele ukuqhubela phambili kokuncipha kwengqondo. Izifundo ezininzi zabantu ezincinci zibonise inzuzo kwi-cognition kwi-dementia kunye ne-ketogenic diet intervention.
https://pubmed.ncbi.nlm.nih.gov/31996078/
Kuya kuthatha ixesha elingakanani ukwenza ukutya kwe-ketogenic?
Umbuzo wokuqala wokwenyani kukuba ndiza kusebenzisa ixesha elingakanani i-ketogenic yokutya ngaphambi kokuba ndiyazi ukuba iyasebenza kum? Kwaye oko kuyahluka. Kodwa ngokubanzi, abantu baqala ukuqaphela utshintsho kwindlela ingqondo yabo esebenza ngayo kwiiveki ezi-3 ukuya kwezi-6. Kuxhomekeke ekubeni uqhubele phambili kangakanani kwinkqubo yakho yesifo. Kuthatha ixesha elingakanani kunokuxhomekeka ekulungiseni kwakho ukusilela kwezondlo okunokuthi kwenzeke njengenxalenye yendlela yakho yokutya yangaphambili. Kungathatha iinyanga ezi-3 ukuya kwezi-6 zokuzama unyango lwe-metabolic olufana nokutya kwe-ketogenic ukugqiba ukuba luzakusebenzela na. Ngokwesiqhelo, abathengi bazibophelela kwinyanga enye elungileyo, eqinileyo. Kwaye emva koko uthathe isigqibo sokuba bayafuna na ukuqhubeka.
Ndiqala njani?
Unokusebenza nam okanye enye ingcali eqeqeshiweyo ukufunda into etyiwayo, indlela yokoyisa imiqobo, kunye nendlela yokugcina umkhondo weenjongo zakho. Ufanelwe ngumntu onolwazi kuhambo lwakho oya kuthathela ingqalelo iimfuno zakho. Jonga inkqubo yam ye-intanethi eyenzelwe ukukufundisa indlela yokuphatha iingxaki zememori ngokwakho!
Unokutyelela kwakhona iphepha lam lezixhobo ukufumana umntu onolwazi ngempilo yemetabolism onokukunceda kuhambo lwakho lokuya buyisela ingqondo yakho!
Ukuba uyonwabele le post yebhlog ungonwabela ezinye ezixoxa ngokusebenza kwengqondo:
Njengale nto uyifundayo kwibhlog? Ngaba uyafuna ukufunda malunga neewebinars ezizayo, iikhosi, kunye nokubonelela ngenkxaso kunye nokusebenza nam kwiinjongo zakho zempilo? Bhalisa!
Ucaphulo
UDavis JJ, uFournakis N, u-Ellison J. I-Ketogenic Diet yoNyango kunye noThintelo lwe-Dementia: Uphononongo. Ijenali yeGeriatric Psychiatry kunye neNeurology. 2021;34(1):3-10.
https://journals.sagepub.com/doi/abs/10.1177/0891988720901785
Needham, J. & Leonard, JM (2020). Izifo ze-Alzheimer's. I-NetCE. https://www.netce.com/courseoverview.php?courseid=2076
Sukkar, SG, & Muscaritoli, M. (2021). Umbono weklinikhi we-Carbohydrate ephantsi ye-Ketogenic Diets: Ukuphononongwa okuBalisayo. Imida kwisondlo, 8, 642628. https://doi.org/10.3389/fnut.2021.642628
https://www.nia.nih.gov/news/half-alzheimers-disease-cases-may-be-mild
https://medicalxpress.com/news/2014-03-one-quarter-patients-mci-dementia.html
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