Unyango lwe-TBI kunye ne-PTSD
Ngaba ukutya kwe-ketogenic kunokunyanga ukwenzakala kwengqondo okunxunguphalisayo (TBI) kunye ne-post-traumatic stress disorder (PTSD) ngaxeshanye?
Ukutya kwe-ketogenic kunokuba lunyango olusebenzayo kubantu abaphethwe yi-TBI kunye ne-PTSD ngenxa yokukwazi ukuguqula iindlela ekwabelwana ngazo ze-pathology kuzo zombini iziphazamiso. Ukutya kwe-Ketogenic kunciphisa i-neuroinflammation kunye noxinzelelo lwe-oxidative, ibhalansi ye-neurotransmitter hyperexcitability, ukuphucula amandla obuchopho kunye ne-metabolism, kunye nokulawula amanqanaba e-brain-derived neurotrophic factor (BDNF). Izidlo ze-Ketogenic nazo zenza iziphumo ze-neuroprotective ezinokunciphisa amanqanaba omonakalo olandelayo we-neurodeergenerative obonwa kwabo baneengxaki okanye zombini.
Isiqulatho
intshayelelo
Kule post blog, ndiya kubhekisela inqaku elithile lophando.
Monsour, M., Ebedes, D., & Borlongan, CV (2022). Uphononongo lwe-pathology kunye nonyango lwe-TBI kunye ne-PTSD. I-Neurology yoMfuniselo, 114009. https://doi.org/10.1016/j.expneurol.2022.114009
Kwinqaku lophando, ababhali benza umsebenzi omangalisayo wokubonisa i-pathophysiology ekwabelwana ngayo esiyibonayo kwiingqondo zabantu abane-TBI kunye / okanye i-PTSD. Linqaku elinomdla, kwaye i-IMHO yenza uphononongo oluhle kakhulu loncwadi. Ukukhathazeka kwam kwangena xa ndiqaphela ukuba ngelixa aba baphandi bachonga ii-pathologies ezisisiseko kunye nonyango oluqhelekileyo olusetyenziswayo ngoku kunye nonyango olunokwenzeka kwixesha elizayo, ukutya kwe-ketogenic akuzange kufakwe.
Yandothusa kakhulu le nto. Ngoko isicwangciso sam kukubhala le post blog ibhekiselele ngokuthe ngqo kuphando lwabo oluchonga ii-pathologies ezisisiseko kwi-TBI kunye ne-PTSD kwaye uxoxe ngendlela ukutya kwe-ketogenic okuchaphazela ngayo ezo ndlela zifanayo ngelixa utsalwa kwiincwadi zophando ukwenza imeko yam.
Emva koko ndiza kubelana ngesi sithuba sebhlog kunye nababhali bokufunda kwaye ndibone ukuba bacinga ntoni.
Kungenzeka ukuba ukutya kwe-ketogenic kwakungekho kwi-radar yabo njengonyango olunokubakho. Okanye mhlawumbi ayizange ihlangabezane nohlobo oluthile lwekhrayitheriya ababenayo yokubandakanywa kwayo. Kodwa aba baphandi babengenamdla okhuphisanayo onokuthi undenze ndicinge ukuba abafuni kwazi ngayo kwaye bavuleleke ekuqwalaselweni kwayo. Yaye mhlawumbi ukuba sisabelana nabanye ngoko sikwaziyo, baya kukulungela ukukuxubusha kwimpapasho yexesha elizayo exubusha loo mbandela.
Kodwa kuqala, makhe sithethe ngezi zifo zimbini.
Ukwenzakala kwengqondo okubuhlungu (TBI) kunye nokwenzakala emva kokwenzakala kwengqondo kuxilongo ezibini olwahlukileyo oluhlala lubonwa kunye kwindidi ezahlukeneyo zabantu kodwa lubonwa lusenzeka ngokubambisana kwabo banenkonzo yasemkhosini phesheya kweelwandle, amaxhoba obundlobongela basekhaya, kunye neengozi zomzimba apho ukwenzakala entloko.
I-TBI ngokuqhelekileyo ichazwa njengokwenzakala kwengqondo ngenxa yamandla angaphandle kwaye inokuqala ukusuka kobulali ukuya kobunzima. Iimpawu zingabandakanya intloko ebuhlungu, isiyezi, i-tinnitus, kunye neempawu zengqondo. Iimpawu zengqondo zingabandakanya utshintsho lwentetho, ukugxila, kunye nokukhubazeka kwememori. Abantu abaye bafumana ukwenzakala kakhulu kwe-TBI banokuba nemikrwelo yengqondo (ukuqhawuka), ukudumba okungapheliyo, kunye nezinye iipathologies ezibonakalayo.
Zifana njani i-TBI kunye ne-PTSD?
Abantu abaninzi abaye bahlakulela i-PTSD baye bafumana ukwenzakala ngokomzimba okubangele ukwenzakala kwe-TBI. Ngelixa olu nxulumaniso lonxibelelwano luchanekile kwaye lubonakaliswe kuphando, ukufana akupheli apho. Zombini zikhona kunye nezikhalazo ze-neurological kunye nezengqondo, ezibandakanya:
- ixhala
- ukucaphuka
- ugwayi
- ukuphazamiseka kwengqondo
Akumangalisi ukuba, abantu abahlangabezana nemilinganiselo yazo zombini i-PTSD kunye ne-TBI baneziphumo ezibi kakhulu ngaphandle konyango olusebenzayo.
Zombini iimeko ziqhutyelwa ngeendlela ezisisiseko ze-neuroinflammation, uxinzelelo lwe-oxidative, ukungalingani kwe-neurotransmitter ye-excitotoxic, kwaye, akumangalisi, utshintsho kwisakhiwo sobuchopho.
Ezi ndlela zisisiseko azenzeki nje kube kanye ngexesha lokonzakala ngokwasemzimbeni okanye ngokweemvakalelo kwaye emva koko ziyeke. Ezi ndlela zingaqwalaselwanga zinegalelo ekugugeni kwe-neurodeergenerative, kubangele ukonakala okuqhubelekayo kunye neempawu. Ayiyothiyori ingekho ngqiqweni ukuba ukufana kweempawu ezibonwayo phakathi kwezi meko zombini kungenxa yokudibana okubalulekileyo kwiindlela ezisisiseko ze-pathology.
Kwinqaku lophando elikhankanywe ngasentla, ababhali baxoxa ngeendlela zonyango ezikhoyo kwezo ngxaki. Ezinye zezo zifanelekileyo kwingxoxo yethu ziinkqubo ze-stem cell exogenous, i-Hyperbaric Oxygen Therapy (HBOT), kunye namayeza. Ukutya kwe-ketogenic kufuneka kufakwe kweli nqaku ngababhali njengolunye unyango lwe-TBI kunye ne-PTSD.
Ngoba? Ngenxa yezi zizathu zilandelayo:
- Iiseli zeziqu ziyahlasela. Iinkqubo ezihlaselayo zinemingcipheko. Iiseli zestem lungenelelo lonyango olubiza kakhulu.
- Ayinguye wonke umntu one-PTSD kunye ne-TBI onokufikelela kwi-HBOT kwizibhedlele zomkhosi okanye une-inshurensi eya kuyigubungela, kwaye bayasokola ngoku!
- Ukuba amayeza ebesoloko eluncedo, besingenakuba baninzi kangaka abasabandezelekayo. Ukuphuhliswa kwamayeza amatsha kuyabiza kwaye kuthatha ixesha. Yaye kwakhona, abantu bayabandezeleka ngoku.
- Ukutya kwe-ketogenic sele kuhlaziywe kwiincwadi zenzululwazi njengonyango olunokubakho lwe-TBI, kwaye umnxeba we-RCTs uqinisekisiwe ngokupapashwa kweSigaba I solingo olulodwa.
- Uphononongo lwezilwanyana lubonise ukuba iimpuku ezivezwe ngumonzakalo zibonisa i-cerebellar kunye ne-multi-system metabolic reprogramming. I-PTSD ikhula kwi-trauma exposure, kwaye ukutya kwe-ketogenic kungenelelo lwe-metabolic yengqondo.
- Izifundo zemiba epapashiweyo kunye nee-RCTs zikhona kubantu abathile besifo sengqondo apho ukuguqulwa kwe-metabolic kubonwa njenge-pathology esisiseko (umzekelo, isifo se-Alzheimer, i-ALS, i-bipolar disorder, ukuphazamiseka kokusetyenziswa kotywala, kunye ne-schizophrenia), ebonisa iziphumo ezilungileyo zonyango.
- Ukutya kwe-Ketogenic kufuna ixabiso eliphantsi kakhulu lokungenelela kune-stem cell therapy okanye i-HBOT, kunye namayeza. Ubomi bonke bamayeza lithemba elixabisa kakhulu kwiinkampani zeinshorensi kunye nezigulana ngokufanayo. Ukutya kwe-Ketogenic kunokuphunyezwa ekhaya ngesigulane kunye nosapho lwabo kwaye kunokufuna inkxaso yexesha elilinganiselweyo kwisondlo sokutya okanye olunye uhlobo lwe-ketogenic diet professional.
Kule post blog, siza kuxoxa ngeendlela ezisisiseko ze-pathological ezichongiweyo kweli nqaku kubantu abaphethwe yi-PTSD kunye / okanye i-TBI. Ukusebenzisa uncwadi olukhoyo kwimiphumo yokutya kwe-ketogenic kwezo ndlela, siya kwenza imeko yokuba ukutya kwe-ketogenic kufuneka kufakwe kwinqaku lophando.
Ngokuthumela eli nqaku, siya kuzama ukunceda abantu abane-PTSD kunye/okanye i-TBI bafunde zonke iindlela zokuziva bebhetele.
I-Pathophysiology ekwabelwana ngayo phakathi kwe-TBI kunye ne-PTSD
Iimpawu ezityhutyhayo kunye ne-comorbidity ye-TBI kunye ne-PTSD inokunxulumana nokudibana okubalulekileyo kwi-pathophysiology esisiseko. Zombini iziphazamiso ze-neurological zibonisa i-neuroinflammation enkulu, uxinzelelo lwe-oxidative, i-excitotoxicity, kunye notshintsho lwesakhiwo.
Monsour, M., Ebedes, D., & Borlongan, CV (2022). Uphononongo lwe-pathology kunye nonyango lwe-TBI kunye ne-PTSD. I-Neurology yoMfuniselo, 114009. https://doi.org/10.1016/j.expneurol.2022.114009
Neuroinflammation
Enye yezona zinto zonakalisayo ezenzeka kwi-TBI yi-neuroinflammation. Ukukhutshwa kwe-cytokines ye-proinflammatory ezifana ne-IL-1, i-IL-12, i-TNF-α, kunye ne-IFN-γ ikhutshwe ngumsebenzi we-immune system kwingqondo. I-immune system iyasebenza ekuphenduleni uhlaselo lomzimba (okanye lweemvakalelo) olwenzekileyo. Lo msebenzi wonyusa iiseli zokuzikhusela kwingqondo ebizwa ngokuba yimicroglia. Badala amanqanaba aphezulu kakhulu okuvuvukala kwaye bakhuthaze imijikelezo ye-neuroinflammatory engapheliyo. Le mijikelezo ye-neuroinflammatory ikhokelela ekonakaleni ngakumbi kweeseli kunye nokufa kwe-neuronal. Njengoko ii-neuron zisenzakala ngakumbi kwaye zisifa zikhulula ii-neurotransmitters ezinomdla njenge-glutamate, ethi emva koko ikhuthaze ukungalingani kwe-neurotransmitter. Umonakalo kwi-blood-brain barrier (BBB) kwenzeka ngenxa yokukhululwa kwe-cytokine eyongezelelweyo yi-astrocytes. Lo monakalo kwisithintelo segazi-ingqondo kwandisa i-neuronal immune system reactivity kunye neenkqubo ezivuthayo. Ukugcina imeko ye-neurotoxic kude ngaphaya kokwenzakala ngokwasemzimbeni okanye ngokweemvakalelo kwe-TBI kunye/okanye ne-PTSD.
I-PTSD inempendulo efanayo ye-neuroinflammation kwi-TBI. Zombini zibonisa ukonyuka kwe-cytokines ye-pro-ukudumba, kodwa ukukhululwa okwandisiweyo kuza emva kwesehlo esicinezelayo endaweni yokwenzakala emzimbeni, njengoko kubonwa kwi-TBI. Zombini i-TBI kunye ne-PTSD zinokubonisa umsebenzi ongapheliyo we-microglia kumashumi eminyaka kamva, udala umonakalo ongakumbi kwii-neurons ngalo lonke ixesha zihlala zisebenza.
Izidlo ze-Ketogenic zimodyuli ezigqwesileyo ze-neuroinflammation. Kukho isiphumo esiqinisekisiweyo esibhaliweyo, ngakumbi ekusetyenzisweni kwayo kwisifo sokuxhuzula esinganyangekiyo kunyango. Kucingelwa ukuba ukutya kwe-ketogenic kulungelelanisa i-neuroinflammation ngeendlela ezininzi ezahlukeneyo, ezinokubandakanya ukuguqulwa kwe-gut microbiome, ukunciphisa amanqanaba eswekile yegazi aqhubela phambili ukuvutha, kunye nemizimba ye-ketone ngokwayo.
I-Ketones zisebenza njenge-molecule ebonisa i-modulates ye-gene expression echaphazelekayo kwiindlela ezingapheliyo ezivuthayo. Izifundo ezininzi zibonise ukuba uhlobo olulodwa lwe-ketone, olubizwa ngokuba yi-β-hydroxybutyrate (BHB) lunemiphumo kwi-receptors ethile elawula ukusebenza kunye nokukhululwa kwe-cytokines e-pro-inflammatory efana ne-IL-1β kunye ne-IL-18.
Ezi zidumbu ze-ketone ziye zabonwa ukuba zineempembelelo ezintle kwi-blood-brain barrier (BBB) yokusebenza kunye neenkqubo zokulungisa. Kucingelwa ukuba oku kwenzeka ngenxa yokuphuculwa kwamandla kwii-astrocyte ezikwazi ukulungisa nokugcina umqobo wegazi-ingqondo (BBB) kwaye ngoko ke ukunciphisa iimolekyuli ezivuthayo ezivela kwi-immune system. Oku kunokuba yinto ebalulekileyo enokuphucula amathuba okunciphisa impendulo engapheliyo ye-neuroinflammatory esiyibona i-post-TBI kunye ne-PTSD.
Iziphumo ze-ketones ukulungelelanisa ukuvuvukala kuboniswe kwi-vitro kunye ne-vivo. Kutheni le nto ingayi kuba sisicwangciso sokuqala sonyango, esigxininisiweyo kuncwadi lwezenzululwazi ukunceda ukunyanga izifo ezisisiseko kwi-TBI kunye ne-PTSD, ngokuphandle ngaphaya kwam. Andikwazi nje ukuqonda ukuba kutheni ingafakwanga kolu hlaziyo lubalaseleyo ngababhali.
Kodwa masiqhubeke sijonge kwi-pathology esisiseko kwaye sibone ukuba yeyiphi enye into enokwenziwa kukutya kwe-ketogenic kubantu abane-TBI kunye ne-PTSD.
Uxinzelelo oluxhasayo
Nje ukuba ufumane impendulo engapheliyo yokugonywa komzimba ivuselelwe kwingqondo ngayo yonke loo nto isebenzayo ye-microglial, uyakha into ebizwa ngokuba luxinzelelo lwe-oxidative. Uxinzelelo lwe-oxidative lwenzeka xa iimfuno zokulungiswa kweeseli zingaphezulu kwe-antioxidant yakho yangaphakathi kunye ne-micronutrient systems inokusingatha. Iinwebu zeseli ziyayeka ukusebenza kakuhle, iivenkile ze-micronutrient ziyaphela, kwaye iiseli ziphelelwa ngamandla ngenxa yokuba zingenawo amandla aneleyo okuzilungisa, singasathethi ke ngomlilo, kwaye zisebenza kakuhle. Bayafa, kwaye bahlala bephazamisa ibhalansi ye-neurotransmitter ekufutshane kwiiseli ezibangqongileyo xa behamba. Uxinzelelo lwe-oxidative luqhuba ukuguga kwe-neurocognitive ngokukhawuleza kunokuba bekuya kwenzeka.
Abantu abane-TBI kunye ne-PTSD bobabini banamanqanaba aphezulu oxinzelelo lwe-oxidative. Kwaye kunzima ukunxibelelana kwinqanaba apho uxinzelelo lwe-oxidative luphazamisa ukusebenza kwengqondo eqhelekileyo. Kodwa ababhali benza umsebenzi omhle kakhulu wokuyenza icace kwisicatshulwa esilandelayo kwinqaku.
Kwi-TBI, i-PTSD, kunye
Monsour, M., Ebedes, D., & Borlongan, CV (2022). Uphononongo lwe-pathology kunye nonyango lwe-TBI kunye ne-PTSD. I-neurology yovavanyo, 114009. https://doi.org/10.1016/j.expneurol.2022.114009
imeko edibeneyo, iintlobo ezisebenzayo zikhokelela kwi-BBB eqhubelekayo,
ukuguqula iplastiki ye-neuronal, ukuphazamisa ukuhanjiswa kwe-neurotransmission, kunye nokutshintsha
i-neuronal morphology kumagqala kunye nemizekelo yezilwanyana
Ke yintoni ukutya kwe ketogenic ukunika amanqanaba aphezulu oxinzelelo lwe-oxidative? Kakhulu, ngokwenene. Ukutya kwe-Ketogenic, kunye neeketoni ezo zidlo zidala, phatha uxinzelelo lwe-oxidative ngeendlela ezininzi. Okokuqala, baphucula amandla eseli ukwenzela ukuba ukulungiswa kweeseli kunye nokugcinwa kuyenzeka. La mandla aphuculweyo anceda iseli isebenze ngcono. Amandla eseli aphuculweyo avela kwiiketoni avumela i-membrane yeseli ukuba isebenze ngcono, oku kuthetha ukuba iyakwazi ukugcina izondlo eziyimfuneko ekudalweni kwee-cofactors ezibalulekileyo ekugcinweni kweeseli kunye nokudalwa kwe-neurotransmitter. Ke kwizidlo ze-ketogenic, siphucula amandla kunye nempilo yeeseli ngendlela yokuba kukho iziphumo ze-neuroprotective ezigqithisayo zoxinzelelo lwe-oxidative.
Enye into eyenziwa yi-ketones echaphazela ngokuthe ngqo amanqanaba oxinzelelo lwe-oxidative kwingqondo kukulawulwa kwe-antioxidants engapheliyo, njenge-glutathione. I-Glutathione sisikhukuli esinamandla sohlobo lweoksijini esebenzayo, ethi iquat iphume esandleni xa ingqondo yonganyelwe luxinzelelo lwe-oxidative. Ukuba ubune-TBI kunye/okanye i-PTSD, ngaba ubungefuni ukuba eyona nto inamandla yokuchasa ukudumba ilawuleke kwaye isebenze ngokupheleleyo?
Ezi ziphumo zibonisa ngamandla ukuba ii-ketones ziphucula i-post-TBI ye-metabolism ye-cerebral ngokubonelela ngezinye ii-substrates kunye ne-antioxidant properties, ukuthintela ukungasebenzi kwe-mitochondrial yoxinzelelo lwe-oxidative.
Greco, T., Glenn, TC, Hovda, DA, & Prins, ML (2016). Ukutya kwe-Ketogenic kunciphisa uxinzelelo lwe-oxidative kunye nokuphucula umsebenzi onzima wokuphefumla we-mitochondrial. Ijenali yokuhamba kwegazi leCerebral kunye neMetabolism, 36(9), 1603-1613. https://doi.org/10.1177/0271678X15610584
Kukho ngokwenene umzimba osele unomtsalane wophando usebenzisa izidlo ze-ketogenic njengonyango lwe-TBI. Ke andiqondi ukuba kutheni ababhali, abenza ingxoxo yokuba kukho i-pathology ekwabelwana ngayo, bengazukuyikhankanya njengonyango olunokubakho kwabo banengxaki enye okanye zombini.
Excitotoxicity, aka ukungalingani neurotransmitter
Ke yonke loo neuroinflammation iphelisa amandla okulungisa iiseli. Kwaye xa ulungelelwaniso phakathi kokulungiswa kunye nomonakalo uphuma kwi-whack, unamazinga aphezulu oxinzelelo lwe-oxidative. Kwaye loo manqanaba aphezulu oxinzelelo lwe-oxidative enza izinto ezimbalwa ezahlukeneyo kwii-neurotransmitters. Ngoko ke akumangalisi ukuba kwi-TBI kunye ne-PTSD, sibona ukugcoba kwiindawo ze-cortical kunye ne-hippocampus yobuchopho ekucingelwa ukuba kungenxa yokwanda kwemveliso ye-glutamate. Kumelwe ukuba kubekho izixa ezaneleyo ze-neurotransmitter evimbelayo ebizwa ngokuba yi-GABA ekufuneka igcine le nkqubo ilungelelene. Kodwa xa imeko apho ingqondo yakho izama ukwenza ii-neurotransmitters izele luxinzelelo lwe-oxidative kunye nokudumba, ayilungelelanisi ezi neurotransmitters.
Kwiimodeli zezilwanyana ze-PTSD kunye ne-TBI edibeneyo, sibona utshintsho kwikhono lobuchopho lokumodareyitha ezi zimbini ze-neurotransmitters. Kukho i-glutamate eninzi kwaye ayikho ngokwaneleyo i-GABA kwiimali ezifanelekileyo okanye ukuxhoma kwiindawo ezifanelekileyo. Oku kungalingani kwe-neurotransmitter kunokuphazamisa ulawulo kwi-cortex yangaphambili, efuna ukusebenza ukuze kucwangciswe ukuziphatha, ukulawula imvakalelo, kunye nokwenza inkitha yeminye imisebenzi ebalulekileyo yesigqeba esihlala siyibona iphazamiseka kubantu abane-TBI kunye / okanye i-PTSD.
Ngoko kwakhona, ndididekile ukuba kutheni, ukuba kukho ukuphazamiseka kwinkqubo ye-glutamate / GABA kulabo abane-TBI kunye ne-PTSD, ababhali abayi kucula iingenelo ezinokubakho zokutya kwe-ketogenic.
Imiphumo yokutya kwe-ketogenic kwinkqubo ye-glutamate / GABA ibhalwe kakuhle, kwakhona kwiincwadi malunga ne-epilepsy enganyangekiyo kunyango. Ukunyuswa kweGABA ye-neurotransmitter eyenzekayo kwi-ketogenic yokutya kuye kwacatshangelwa njengenye yeendlela ezisisiseko zokunciphisa ukubanjwa kolu luntu.
Enye indlela yokutya kwe-ketogenic kubonwe ukuphucula ibhalansi ye-neurotransmitter kunye nokunciphisa i-hyperexcitability kumandla ayo okuphucula ukusebenza kwe-neuronal membrane. Oku kunefuthe elithe ngqo kwiitshaneli ze-calcium ion, ukuba zivutha kaninzi kangakanani kwaye ziba yimincili kangakanani. Oku kuye kwachazwa njengesixhobo apho ukutya kwe-ketogenic kunceda ukunciphisa ukubanjwa rhoqo kuluntu lokuxhuzula.
Ke kwakhona, kunye nokutya kwe-ketogenic okuneziphumo ezibhalwe kakuhle ekusebenzeni kwe-neurotransmitter kunye nomsebenzi we-neuronal membrane, ndihlala ndingaqinisekanga ukuba kutheni kungabhekiswanga okanye kuxoxwe njengonyango olunokubakho lwe-TBI ye-comorbid kunye ne-PTSD.
Ukumila kobuchopho
Kuyo nayiphi na ingxaki ene-neuroinflammation engapheliyo, amanqanaba aphezulu oxinzelelo lwe-oxidative, kunye nokungalingani kwe-neurotransmitter, uya kubona utshintsho lokwenyani kwizakhiwo zomzimba zobuchopho. Amanye amalungu aya kuba makhulu okanye abe mancinci, kwaye amanye amalungu aya kunxibelelana namanye ngeendlela ezingaqhelekanga. Impilo yee-neuron sisiseko somsebenzi wokwenyani wazo zonke ezo zakhiwo. Kubantu abane-TBI, olu tshintsho lwe-morphological kunye nokuphazamiseka koqhagamshelwano phakathi kwezakhiwo zengqondo kunokuqhutyelwa phambili ngokuchetywa kwe-axonal eyenzekileyo njengenxalenye yokwenzakala.
Ngoko akumangalisi ukuba ababhali baqhubeke bethetha malunga noshintsho lwengqondo olubonwa kwabo babandezeleka kwi-TBI kunye ne-PTSD. Abaphandi bafumene utshintsho olukhulu kwisakhiwo sobuchopho kunye nokunxibelelana kwabo bane-TBI kunye ne-PTSD.
Izinto ezingaqhelekanga zenethiwekhi yolawulo lwengqondo ye-fronto-cingulo-parietal, ebandakanyeka kulwazi, inkumbulo, ingqalelo, kunye nokuthintela ukusetyenzwa koloyiko kubalulekile ekuqondeni i-TBI kunye ne-PTSD.
Monsour, M., Ebedes, D., & Borlongan, CV (2022). Uphononongo lwe-pathology kunye nonyango lwe-TBI kunye ne-PTSD. I-neurology yovavanyo, 114009. https://doi.org/10.1016/j.expneurol.2022.114009
Izigulana ezine-PTSD kunye ne-TBI zibonisa utshintsho olufanayo kwizakhiwo zobuchopho, kwaye oku kucingelwa ukuba negalelo kwi-symptomology ekwabelwana ngayo ngokumoyika okungaqhelekanga, ukuxhatshazwa ngokweemvakalelo, kunye ne-inhibited prefrontal cortex metabolism.
Kukho ubuncinci iindlela ezimbini zesenzo kwi-ketogenic yokutya enokuba yonyango olusebenzayo kule miba. Ngelixa iindlela zangaphambili ezixutyushwayo zinokuphucula iimeko kwingqondo ukuze kuncitshiswe ukubakho okanye ubunzima bexesha elide le-brain morphology ngokunciphisa ukuvuvukala kunye noxinzelelo lwe-oxidative, kukho izinto ezongezelelweyo zokutya kwe-ketogenic ezinokunceda ukujongana ne-morphology yobuchopho engaqhelekanga kule nto. abemi.
Okokuqala, ukutya kwe-ketogenic kungenelelo lwe-metabolic. Sele sizisebenzisa ekuphuculeni imetabolism yobuchopho kwi-prefrontal cortex, ngakumbi kwabo banesifo se-Alzheimer's. Kutheni le nto singasebenzisi ukutya kwe-ketogenic ukuphucula ingqondo ye-hypometabolism kwi-prefrontal cortex yabo bane-TBI kunye ne-PTSD?
I-Ketones ibonelela ngomthombo wamafutha ofumaneka ngokulula owenziwe ngokulula kwaye ujike ube ngamandla ziiseli zengqondo. Amafutha angena kanye apho, akukho mfuneko yokujongana nabathuthi abaphukileyo okanye abaphazamisekileyo abanokuba ngumqobo kwiingqondo kunye ne-TBI kunye ne-PTSD.
I-Ketones ilawula i-metabolism yobuchopho kungekuphela nje ngokubonelela ngolunye umthombo wamafutha kodwa ngokwandisa ngokoqobo inani kunye nempilo ye-mitochondria. IMitochondria ziibhetri zeeseli zakho. Ukuba ufuna amandla amaninzi eeseli kunye nokusetyenziswa okungcono kwamandla eseli, udinga i-mitochondria eninzi esempilweni nesebenzayo. Ukunyuswa kwinani kunye nokusebenza kwe-mitochondria ye-TBI kunye ne-PTSD yobuchopho lungenelelo olunamandla kwi-brain structure hypometabolism. Ukungajongani ne-hypometabolism kuya kukhokelela ekucuthekeni kwe-lobe yangaphambili kwaye kubangele unxibelelwano olungahambi kakuhle kwezinye izakhiwo ngokuhamba kwexesha.
Enye into eyenziwa yi-ketones eya kuba luncedo kwingqondo egcwele uxhulumaniso olunganelanga okanye oluphazamisekileyo kukulawula i-BDNF. I-BDNF imele i-brain-derived neurotrophic factor, kwaye inceda ukuphilisa ingqondo kwaye inceda ekufundeni nasekukhumbuleni. Kwaye idlala indima ebalulekileyo kunxibelelwano lwe-synaptic. Ngaba ufuna ukubuyisela ingqondo kwisiqhelo? Uya kufuna i-BDNF. Uninzi lwalo kunye namandla amaninzi awongezelelweyo anikezelwa yi-mitochondrial upregulation oyibonayo kwizidlo ze-ketogenic.
isiphelo
Ababhali bayavuma ukuba ngelixa uninzi lwezigulana ze-TBI/PTSD zifumana unyango lokubuyisela kwisimo sangaphambili, olo khathalelo alwanelanga ukujongana nezinto eziqhubekayo ze-neurodegeneration ezinegalelo ekwandiseni isifo kunye nokuqhubekeka kweempawu.
Baqhubela phambili kwinqaku ukuxoxa ngonyango oluthembisayo olunje nge-hyperbaric oxygen therapy (HBOT), endiyi fan enkulu, kunye nonyango lwe-stem cell. Zombini ezi zonyango ziya kuba yinto emangalisayo kubantu abane-TBI kunye ne-PTSD, kwaye banesiseko esihle sophando senkxaso njengonyango olusebenzayo. Nangona kunjalo, zibiza kakhulu, kwaye ayinguye wonke umntu onokufikelela okwaneleyo kolu nyango nangona besiyakufuna.
Ke kwabo bangafuniyo okanye abangakwaziyo ukuhlawula inkqubo ye-neuronal stem cell okanye abanakho ukufikelela kwi-hyperbaric oxygen kwisibhedlele somkhosi sasekhaya, ndifuna wazi ukuba eyona ndlela isisiseko yolu nyango iyafikeleleka kusetyenziswa ukutya kwe-ketogenic. I-BHB, uhlobo lomzimba we-ketone oveliswe kwi-ketogenic diet, inokunyusa i-BDNF.
I-BHB inokuphinda ilawule ukubonakaliswa kwe-brain-derived neurotrophic factor (BDNF) kwaye ngaloo ndlela inokukhuthaza i-mitochondrial biogenesis, i-synaptic plasticity kunye nokuchasana noxinzelelo lweselula.
Mattson, MP, Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018). Ukutshintsha kwe-metabolic okungapheliyo, i-neuroplasticity kunye nempilo yengqondo. Uphengululo lwendalo. I-Neuroscience, 19(2), 63-80. https://doi.org/10.1038/nrn.2017.156
Xa iiseli ze-neural stem zisetyenziswa kuphononongo lwesifo sika-Alzheimer, i-BDNF ichongiwe njengeyona ndlela iphambili ekuphuculeni okulungileyo. I-HBOT yaziwa ngokunyusa amanqanaba e-BDNF kakhulu kwaye yenye yeendlela apho ukuphuculwa kwe-TBI kuphunyezwa.
Ke ngelixa ndingathandabuzi ukuba zombini i-HBOT kunye nonyango lwe-stem cell lunokuba lunyango olusebenzayo lwe-TBI kunye/okanye i-PTSD, ndicinga ukuba kubalulekile ukuba inqaku libe banzi. Ngokukodwa ekubeni ukutya kwe-ketogenic kunoncwadi lophando oluxhasayo njengonyango lweendlela ezisisiseko ababhali abachongiweyo njengezinto ezifanayo phakathi kwezi zifo zimbini. Kwaye ndiyathemba ukuba baya kubandakanya ukutya kwe-ketogenic kumsebenzi wabo wexesha elizayo okanye babhale uhlobo oluthile lwesongezo oluya kunceda ukwazisa oogqirha kunye nabaphandi bokutya kwe-ketogenic njengonyango olunokubakho lwe-TBI kunye ne-PTSD.
Ukutya kwe-Ketogenic kuyafikeleleka kwaye kungenelelo oluzinzileyo kwiindidi ezahlukeneyo ze-neurological disorders, kuquka i-TBI kunye ne-PTSD. Ukuba unomdla malunga neendlela ezisisiseko zolunye ukuphazamiseka, ungonwabela izithuba ezininzi ezikhoyo kwi Impilo yengqondo Keto Blog.
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Ucaphulo
Uphononongo lwe-pathology kunye nonyango lwe-TBI kunye ne-PTSD - ScienceDirect. (nd). Ifunyenwe ngoFebruwari 15, 2022, ukusuka https://www.sciencedirect.com/science/article/pii/S0014488622000346
Achanta, LB, & Rae, CD (2017). I-β-Hydroxybutyrate kwiBrain: I-Molekyuli enye, iiMechanism ezininzi. Uphando lwe-Neurochemical, 42(1), 35-49. https://doi.org/10.1007/s11064-016-2099-2
Arora, N., Litofsky, NS, Golzy, M., Aneja, R., Staudenmyer, D., Qualls, K., & Patil, S. (2022). Ulingo lweSigaba I esinye seziko lokutya kwe-ketogenic kubantu abadala abanokwenzakala kwengqondo. Isondlo seKlinikhi ye-ESPEN, 47, 339-345. https://doi.org/10.1016/j.clnesp.2021.11.015
I-Arora, N., & Mehta, TR (2020). Indima yokutya kwe-ketogenic kwizifo ezinzulu ze-neurological. I-Neurology yeklinikhi kunye ne-Neurosurgery, 192, 105727. https://doi.org/10.1016/j.clineuro.2020.105727
Banjara, M., & Janigro, D. (nd). Iimpembelelo ze-Ketogenic Diet kwi-Blood-Brain Barrier. Kwi Ukutya kwe-Ketogenic kunye noNyango lweMetabolic. Oxford University Press. Ibuyiselwe nge-8 kaJanuwari 2022, ukusuka https://oxfordmedicine.com/view/10.1093/med/9780190497996.001.0001/med-9780190497996-chapter-30
Blurton-Jones, M., Kitazawa, M., Martinez-Coria, H., Castello, NA, Müller, F.-J., Loring, JF, Yamasaki, TR, Poon, WW, Green, KN, & LaFerla, FM (2009). Iiseli ze-Neural stem ziphucula ukuqonda nge-BDNF kwimodeli ye-transgenic yesifo se-Alzheimer. Iinkqubo ze-National Academy of Sciences, 106(32), 13594-13599. https://doi.org/10.1073/pnas.0901402106
Dąbek, A., Wojtala, M., Pirola, L., & Balcerczyk, A. (2020). Ukumodareyithwa kweCellular Biochemistry, Epigenetics kunye neMetabolomics yiKetone Bodies. Iimpembelelo ze-Ketogenic Diet kwi-Physiology ye-Organism kunye ne-Pathological States. Amanzi, 12(3), 788. https://doi.org/10.3390/nu12030788
Dahlin, M., Elfving, A., Ungerstedt, U., & Amark, P. (2005). Ukutya kwe-ketogenic kuchaphazela amanqanaba e-excitatory kunye ne-inhibitory amino acids kwi-CSF kubantwana abane-refractory epilepsy. Uphando lweSithuthwane, 64(3), 115-125. https://doi.org/10.1016/j.eplepsyres.2005.03.008
Dilimulati, D., Zhang, F., Shao, S., Lv, T., Lu, Q., Cao, M., Jin, Y., Jia, F., & Zhang, X. (2022). Ukutya kwe-Ketogenic Modulates Neuroinflammation ngeMetabolites esuka kwiLactobacillus reuteri emva kokulimala okuPhindayo okuPhindayo okuNzakalayo okuNzakala kwengqondo kwiiMice ezifikisayo [Ushicilelo lwangaphambili]. Kuphononongo. https://doi.org/10.21203/rs.3.rs-1155536/v1
UDowis, K., & Banga, S. (2021). IiNzuzo ezinokuthi zibekho kwiMpilo ye-Ketogenic Diet: Uphononongo oluBalisayo. Amanzi, 13(5). https://doi.org/10.3390/nu13051654
Greco, T., Glenn, TC, Hovda, DA, & Prins, ML (2016). Ukutya kwe-Ketogenic kunciphisa uxinzelelo lwe-oxidative kunye nokuphucula umsebenzi onzima wokuphefumla we-mitochondrial. Ijenali yokuhamba kwegazi leCerebral kunye neMetabolism, 36(9), 1603. https://doi.org/10.1177/0271678X15610584
Hartman, AL, Gasior, M., Vining, EPG, & Rogawski, MA (2007). I-Neuropharmacology ye-Ketogenic Diet. I-Neurology yezilwanyana, 36(5), 281. https://doi.org/10.1016/j.pediatrneurol.2007.02.008
Unyango lwe-oxygen ye-hyperbaric ikhuthaza ukuphuculwa kwe-neurological recovery kwiigundane ezinokulimala kwengqondo ehambelana nokusebenza kwe-TrkB-Dan-2018-Ibrain-Wiley Online Library. (nd). Ifunyenwe ngoFebruwari 19, 2022, ukusuka https://onlinelibrary.wiley.com/doi/full/10.1002/j.2769-2795.2018.tb00029.x
Jarrett, SG, Milder, JB, Liang, L.-P., & Patel, M. (2008). Ukutya kwe-ketogenic kwandisa amanqanaba e-mitochondrial glutathione. Journal of Neurochemistry, 106(3), 1044-1051. https://doi.org/10.1111/j.1471-4159.2008.05460.x
Koh, S., Dupuis, N., & Auvin, S. (2020). Ukutya kwe-Ketogenic kunye ne-Neuroinflammation. Uphando lweSithuthwane, 167, 106454. https://doi.org/10.1016/j.eplepsyres.2020.106454
Mattson, MP, Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018). Ukutshintsha kwe-metabolic okungapheliyo, i-neuroplasticity kunye nempilo yengqondo. UPhononongo lweNdalo. I-Neuroscience, 19(2), 63. https://doi.org/10.1038/nrn.2017.156
McDonald, TJW, & Cervenka, MC (2018). Ukutya kwe-Ketogenic kwi-Adult Neurological Disorders. Neurotherapeutics, 15(4), 1018. https://doi.org/10.1007/s13311-018-0666-8
McDougall, A., Bayley, M., & Munce, SE (2018). Ukutya kwe-ketogenic njengonyango lokulimala kwengqondo ebuhlungu: ukuphononongwa kwe-scoping. Ukulimala Ubunzima, 32(4), 416-422. https://doi.org/10.1080/02699052.2018.1429025
Newman, JC, & Verdin, E. (2017). I-β-Hydroxybutyrate: Umqondiso weMetabolite. Uphononongo loNyaka lweSondlo, 37, 51. https://doi.org/10.1146/annurev-nutr-071816-064916
Norwitz, NG, Dalai, Sethi., & Palmer, CM (2020). Ukutya kwe-Ketogenic njengonyango lwe-metabolic kwisigulo sengqondo. Uluvo lwangoku kwi-Endocrinology, isifo seswekile kunye nokutyeba kakhulu, 27(5), 269-274. https://doi.org/10.1097/MED.0000000000000564
Offermanns, S., & Schwaninger, M. (2015). Ukusebenza kwezondlo okanye kwe-pharmacological yeHCA2 kuphucula i-neuroinflammation. Iintlobo zeModuli yeMelecular, 21(4), 245-255. https://doi.org/10.1016/j.molmed.2015.02.002
Preston, G., Emmerzaal, T., Radenkovic, S., Lanza, IR, Oglesbee, D., Morava, E., & Kozicz, T. (2021). I-Cerebellar kunye ne-multi-system metabolic reprogramming ehambelana nokuvezwa kwe-trauma kunye ne-post-traumatic stress disorder (PTSD) -efana nokuziphatha kwiimpuku. I-Neurobiology yoXinzelelo, 14, 100300. https://doi.org/10.1016/j.ynstr.2021.100300
SciELO - BrazilUmphumo wokukhusela kunye nenkqubo yonyango lwe-hyperbaric oksijini kwingqondo yegundane kunye nokulimala okubuhlungu Umphumo wokukhusela kunye nenkqubo yonyango lwe-hyperbaric oksijini kwingqondo yegundane kunye nokulimala okubuhlungu. (nd). Ifunyenwe ngoFebruwari 19, 2022, ukusuka https://www.scielo.br/j/acb/a/HjTbd5M57J6XFV8jVkcBbTb/abstract/?lang=en
Yarar-Fisher, C., Li, J., Womack, ED, Alharbi, A., Seira, O., Kolehmainen, KL, Plunet, WT, Alaeiilkhchi, N., & Tetzlaff, W. (2021). Iirejimeni ze-Ketogenic zeziganeko ezibukhali ze-neurotraumatic. Uluvo lwangoku kwi-Biotechnology, 70, 68-74. https://doi.org/10.1016/j.copbio.2020.12.009
Ying, X., Tu, W., Li, S., Wu, Q., Chen, X., Zhou, Y., Hu, J., Yang, G., & Jiang, S. (2019). Unyango lwe-oksijini ye-Hyperbaric kunciphisa i-apoptosis kunye ne-dendritic / synaptic degeneration ngokusebenzisa i-BDNF / TrkB yokubonisa iindlela kwiigundane ze-SCI. Sciences soBomi, 229, 187-199. https://doi.org/10.1016/j.lfs.2019.05.029
Yudkoff, M., Daikhin, Y., Nissim, I., Lazarow, A., & Nissim, I. (2004). Ukutya kwe-Ketogenic, ingqondo ye-glutamate metabolism kunye nokulawula ukubamba. I-Prostaglandins, iLeukotrienes, kunye ne-acid ebalulekileyo yeFutty, 70(3), 277-285. https://doi.org/10.1016/j.plefa.2003.07.005
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