Ukutya kwe-ketogenic kunokunceda njani ukunyanga iimpawu ze-Obsessive-Compulsive Disorder (OCD)?

Izidlo ze-Ketogenic ziyakwazi ukuguqula ubuncinane ezine ze-pathologies esizibona kubantu abane-obsessive-compulsive disorder (OCD)). Ezi pathologies ziquka i-glucose hypometabolism, ukungalingani kwe-neurotransmitter, ukuvuvukala, kunye noxinzelelo lwe-oxidative. Ukutya okune-ketogenic lunyango olunamandla lokutya oluye lwaboniswa ukuba luchaphazele ngokuthe ngqo ezi ndlela zine ezisisiseko eziye zachongwa ukuba zibandakanyeka kwi-obsessive-compulsive disorder (OCD).) iimpawu.

intshayelelo

Kule post yebhlog, ndinguye hayi uya kuchaza iimpawu okanye amazinga okuxhaphaka kwe-OCD. Esi sithuba asenzelwanga ukuxilonga okanye ukufundisa ngolo hlobo. Ngaphandle kokutsho ukuba i-OCD inxulumene kakhulu nezinye iziphazamiso ezinje ngeBody Dysmorphic Disorder, Trichotillomania, Hoarding, kunye I-Excoriation Disorder (ebizwa ngokuba yi-skin picking). Ukuba ukhathazwa nakweyiphi na kwabo banesifo okanye ngaphandle kokuxilongwa ngokusesikweni kwe-OCD, unokuxhamla ngokufunda le post yebhlog. Ukuba uyifumene le posti yebhlog, uyazi ukuba yintoni i-OCD kwaye kusenokwenzeka ukuba wena okanye umntu omthandayo usenokuba sele ephethwe yiyo.

Ukuba ufumene le post blog, ukhangela iindlela zonyango. Uzama ukufumana iindlela zokuziva ungcono kwaye uphile.

Ekupheleni kwesi sithuba seblogi, uya kuba nakho ukuqonda ezinye zeendlela ezisisiseko ezingahambi kakuhle kwiingqondo zabantu abaphethwe yi-OCD kunye nendlela ukutya kwe-ketogenic kunokunyanga ngayo ngamnye kubo.

Uza kubuya ubone ukutya kwe-ketogenic njengonyango olunokwenzeka kwiimpawu zakho ze-OCD okanye njengendlela ehambelanayo yokusetyenziswa kwengqondo kunye / okanye endaweni yamayeza.

I-psychopharmacology yangoku isebenzisa i-selective reuptake serotonin inhibitors (SSRIs), rhoqo (kwaye ngethemba) kunye nonyango lokuziphatha kwengqondo (CBT) ukunyanga i-OCD.

Sinokujonga ngokulula iziphumo ebezingalindelekanga zalo naliphi na kula mayeza. Iimpawu ze-OCD kunye nangaphandle kwe-psychotherapy zinokuba buthathaka kwaye zingapheli kwabanye abantu, ukuba ukunyamezela iziphumo ezichaphazelekayo kunokubonakala ngathi ixabiso elincinci lokuhlawula ukuphuculwa komsebenzi. Njengomcebisi wezempilo yengqondo, ndityekele ekusetyenzisweni konyango lwengqondo-yokuziphatha (CBT) kunye nezakhono zokuqonda njengonyango lwe-OCD, ndibona ukuphuculwa kwezigulana ezenza iiprothokholi kunye okanye ngaphandle kwamayeza. Kodwa kwezinye izigulana, amayeza kunye nonyango lwengqondo alwanelanga ukuphucula iimpawu. Kwaye ezinye zezigulana zam aziphucuki kumayeza angoku okanye azinyamezeli iziphumo ebezingalindelekanga zamayeza. Yaye ababodwa.

Nangona kunjalo, ukuya kuthi ga kwisiqingatha sazo zonke izigulana ezine-OCD zingalufumani uxolelo ngonyango lwangoku, zicebisa ukuba kukho izinto ezintsha ezinokubakho kwi-psychopharmacology yesi sifo. 

Szechtman, H., Harvey, BH, Woody, EZ, & Hoffman, KL (2020).  https://doi.org/10.1124/pr.119.017772

Kuba ngaphezu kwesiqingatha sabantu esizama ukubanyanga ngamayeza abaphucukanga, lilungelo lethu kunye noxanduva lwethu ukujonga ngaphandle komgangatho wokhathalelo kwabo baphethwe yi-OCD. Ukucela abantu ababandezelekileyo ukuba balinde de i-psychopharmacology ifumaneke kwaye ibonelele ngonyango olusebenzayo akunabuntu. Ngokukodwa xa kukho ezinye iindlela zokungenelela ezinokungqineka ziluncedo kolu kuphazamiseka kwengqondo.

Ke siza kujonga kuncwadi ukuze sifunde ngezinye iindlela ze-pathology esizibonile kubantu abanengxaki yokunyanzelwa yi-obsessive-compulsive disorder (OCD). Siza kuxubusha indlela ukutya kwe-ketogenic kunokuba unyango lweendlela ezisezantsi ezifunyenwe kwinkcazo yempawu kunye ne-OCD.

Loluphi utshintsho lwe-neurobiological olubonwa kubantu abaphethwe yi-OCD?

Edlulileyo isikhundla yangena kwiinkcukacha malunga nendlela ukutya kwe-ketogenic kunokuguqula ngayo iimpawu zokuxhalaba ngokuchaphazela iindawo ezine ze-pathology ezibonwa kwezi ngxaki.

• IGlucose Hypometabolism
• Neurotransmitter Ukungalingani
• Ukuvutha
• Uxinzelelo lwe-oxidative.

Kwi-OCD sibona ezi pathologies zifana zisenzeka. Kukho iindawo zengqondo ezine-hypometabolism (ungasebenzisi amandla ngokufanelekileyo), ukungalingani kwe-neurotransmitter eyahlukileyo echaphazela isimo sengqondo kunye nokuqonda, kunye nokuvuvukala. Kukho nenxalenye yoxinzelelo lwe-oxidative ekhoyo kwi-obsessive-compulsive disorder (OCD) ingqondo, ezenza zibe mandundu iimpawu. Makhe sihlolisise nganye kwezi. Kwaye cinga ukuba ukutya kwe-ketogenic kuzilungisa njani zonke ezi kwaye kunokuphucula ngokufanelekileyo iimpawu.

I-OCD kunye ne-Brain Hypometabolism

Utshintsho kumsebenzi we-glucose luye lwabhalwa kwi i-orbitofrontal cortex (OFC) kwaye i ukuthoba i-nucleus kwaye inokunxibelelana nobukho kunye nokungabikho kweempawu ezinyanzelekileyo (OCD) ezisekelwe kwiziphumo. Izifundo ze-Neuroimaging zisebenzisa i-PET, i-SPECT, kunye ne-fMRI ziye zafumanisa ukuba umsebenzi ophezulu ngokungaqhelekanga wenzeka kuyo yonke i-cortex yangaphambili kunye nezakhiwo ezingaphantsi kwe-subcortical. Kodwa ukuba ngonyango oluyimpumelelo kusetyenziswa ii-SSRIs okanye unyango lokuziphatha lo msebenzi uphezulu ubuyela kumanqanaba aqhelekileyo.  

Ngokuqhelekileyo, sibona i-hypermetabolism kwi-obsessive-compulsive disorder (OCD). Ukwanda kwesantya semetabolism ngasekhohlo i-gyrus ye-orbital kunye ne-bilateral in the caudate nuclei. Kodwa oko akuthethi ukuba akukho nxalenye ye-hypometabolism kwi-OCD. Isenokuxhomekeke ngakumbi kwindlela yokugula kunye nomsebenzi ozanywayo.

I-glucose hypermetabolism kamva ithathelwa indawo yi-hypometabolism kwindawo Ingaphakathi cterxe cortex (ACC). Oku kucingelwa ukuba kwenzeka ngenxa yokuba i-ACC ekugqibeleni iyeka ukwenza imisebenzi eqhelekileyo kule nxalenye yengqondo. Kutheni i-ACC inokwenza oku? Kuba isasaza imisebenzi kwezinye izakhiwo zobuchopho ngenxa yokujikeleza okungaqhelekanga okuphuhlayo ngexesha lokugula. Ubume bobuchopho buya kuthi xhaxhe kwaye bomelele apho kukho umsebenzi owandisiweyo. Iingqondo ziyiplastiki ngokwenene, oku kuthetha ukuba kukho indawo yokugqithisa kakhulu kuya kuguqula ukuba zeziphi izakhiwo zobuchopho eziqhagamshelwe kunye nokuba yeyiphi iqondo.

Ubungqina obuvela kwizifundo ze-neuroimaging bubonisa ukuba ngelixa kukho i-loop enye ye-hyperactivity, kukho i-loop yesibini ukungasebenzi kakuhle phakathi kwe-dorsolateral prefrontal cortex (dlPFC) kunye ne-dorsolateral caudate kwizigulana ezine-OCD. Le hypoactivity kucingelwa ukuba iphantsi kokungaguquki kwengqondo kunye nokusilela kumsebenzi olawulayo obonwa kuvavanyo lwe-neuropsychological kwizigulana ze-OCD.

Ke, i-hypothesis ekhoyo ithi ukungalingani phakathi kwezi sekethe ze-2 sisiseko esisisiseko se-OCD, njengoko i-OFC esebenzayo ivelisa ukunyanzeliswa kunye nezinyanzeliso ezinxulumene nesiko, ngelixa inethiwekhi yesigqeba esilawulayo sithintela umntu ukuba atshintshele kwindlela entsha yokuziphatha.

McGovern, RA, & Sheth, SA (2017). https://doi.org/10.3171/2016.1.JNS15601

Sikwabona ukuba izigulana ze-OCD zibonisa ukungasebenzi kakuhle kwememori enokuthi inyanyaniswe ne-glucose hypometabolism kwi-cortex yangaphambili. Olu thintelo lwenkumbulo lusebenzayo alubandakanyi nje ukuzama ukukhumbula izinto ixesha elifutshane, kodwa lukwabandakanya iingxaki zokubonwa kwesithuba kunye nokusebenza kwesigqeba. Ezi ntsilelo ekusebenzeni kwe-executive, ezinxulunyaniswa ne-hypometabolism yobuchopho, ziyinxalenye yokubonakaliswa kweempawu. Ukuze sibe nolawulo oluthile lweengcinga zethu, okanye sisuse iingcinga zethu kude neengcinga ezisisiseko ezinikelwe kuloyiko nokhuseleko, kufuneka sibe nokusebenza kakuhle kwengqondo. Ngesi sizathu, ndingatsho ukuba i-hypometabolism yinto ekujoliswe kuyo efanelekileyo yongenelelo lwe-neurobiological kwabo bane-OCD.

Kwakhona, andiziboni izigulana ezininzi ezingenayo i-comorbidity nezinye iziphazamiso. Intsingiselo, uninzi lwezigulana zam zinento ebizwa ngokuba luxilongo kabini. Oku kuthetha ukuba abanayo nje i-OCD, kodwa banezinye izifo zengqondo ezihamba kunye nayo. Kwaye enye i-comorbidity endiyibona rhoqo nge-OCD luxinzelelo. Ukudakumba kubonwa rhoqo ukubonisa ubuninzi be-hypometabolism yobuchopho engasebenziyo. Eli candelo libalaseleyo le-hypometabolism linxulunyaniswa ngamandla kwaye kunokwenzeka ukuba libe ngunobangela wokubonakaliswa kweempawu kuxinzelelo ngokubanzi, kwaye lifunyanwa likhona kwabo bane-OCD ye-comorbid.

Ukutya kwe-ketogenic kuyiphatha njani i-hypometabolism kwingqondo ye-OCD

Kodwa linda, ungatsho. Kuthekani ngezinye iindawo zoxinzelelo olukhulu? Ngaba ukutya okune-ketogenic akuzukubavuselela bonke abo kwaye kwenze ukuba loop (isekethe) yengqondo ibe mandundu?

Akunjalo. Ngoba?

Iziphumo zethu zibonisa ukuba ukungazinzi kwenethiwekhi yobuchopho kunokubonakalisa iimpawu zokuqala ze-hypometabolism

Mujica-Parodi, LR, et al., (2020). Ukutya kulungelelanisa uzinzo lwenethiwekhi yobuchopho, i-biomarker yokuguga kwengqondo, kubantu abadala abancinci. https://pubmed.ncbi.nlm.nih.gov/32127481/

Ngenxa yokuba i-pathology ye-hypometabolism yobuchopho ayithethi ukuba ukonwaba kwenzeka ngesizathu esifanayo. Ukutya kwe-ketogenic kunceda ngokwenene uzinzise ukusebenza kwengqondo ngokugqitha oomatshini beeseli ezaphukileyo ezikhokelele ekubeni iseli iphuhlise i-glucose hypometabolism. Kwakhona, izakhiwo ze-neuronal ezixhasayo ezifana ne-astrocyte ziyakwazi ukulawula ukuveliswa kwazo kwe-ketone, ukudala amandla amaninzi kwingqondo. Siza kufunda ngakumbi malunga ne-astrocytes kamva.

I-hyperexcitability kwezinye izakhiwo zobuchopho kunokwenzeka kakhulu ngenxa yokungalingani kwe-neurotransmitter kune-glucose hypometabolism. Ngaba ndiye ndakwazi ukufumanisa ukuba yintoni kanye kanye ebangela ukuba kubekho i-hyperexcitability? Andiqondi ukuba uncwadi luyazi ngokuqinisekileyo ngaphandle kokuba ii-neurons zisokola ngamandla okanye umsebenzi, i-hyperexcitability ingenzeka. Sibona ukungalingani kwe-neurotransmitter okubangela ukuba i-hyperexcitability kwaye siyazi ukuba ukuvuvukala okungathintekiyo kunokonakalisa amandla eseli kwaye kubangele iindawo ze-hypometabolism.

Kodwa ngenxa yokuba ukutya kwe-ketogenic ayilongenelelo kwicandelo elinye lokugula ngengqondo, iindlela ezininzi zonyango lwe-psychopharmacology, ukuphucula ukusetyenziswa kwamandla kwisakhiwo se-hypometabolic akuyi kubangela ukuba enye ivuseleleke ngendlela eyoyikisayo.

Ubungqina bamva nje bubonisa ukuba ukuguqula imetabolism kunye nokutya kwe-ketogenic kwenza ukuba imeko ye-homeostatic kwingqondo ingabi mnandi kangako.

IMasino, SA, & Rho, JM (2019). https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6281876/

Khumbula? Olu ngenelelo lusebenza ubuncinane kwizinto ezine ezingahambi kakuhle (kunye nezinye ezimbalwa eziphonsiweyo esinokuxoxa ngazo ekugqibeleni), kwaye ukuphuculwa kwenkqubo enye akubonakali kungalingani okanye kubangela imiphumo emibi kunye nabanye. Ukutya kwe-ketogenic kubonakala kusebenza ngokupheleleyo kunye nazo zonke iindlela ezibandakanyekayo zokungenelela.

I-OCD kunye ne-Neurotransmitter Ukungalingani

Ukungalingani kwe-neurotransmitter esikubonayo kwi-OCD kubandakanya i-neurotransmitters, kuquka i-serotonin, i-dopamine, i-glutamate, kunye ne-GABA.

Ukungalingani kweSerotonin kudlala indima esebenzayo kwi-OCD. Kangangokuba ubuncinane isiqingatha kunye ne-OCD siphucula amayeza ashiya i-serotonin eninzi ekhoyo kwi-synapses (SSRIs) ukuba isetyenziswe yi-neurons. Zininzi izizathu zokuba kutheni ingqondo isenokungenzi i-serotonin eyaneleyo. Ezinye zisenokungonelanga ziicofactors ezifana nentsimbi, ivithamin D, okanye i-B6, kwaye kusenokwenzeka ukuba akwanelanga izandulela ze-amino acid (IiVegans kunye nabo batya ukutya okuninzi okucutshungulweyo, ndithetha nawe). Kodwa kwi-OCD ukungabikho kwe-serotonin kucingelwa ukuba kudala iingxaki ngokugqithisileyo. Kwaye xa siphatha abanye abantu ngee-SSRIs, ukunyanzeliswa kwabo kuncipha kukuqina kunye nokuphindaphinda. Kodwa ayisebenzi kumntu wonke.

Izibonelelo zeklinikhi ezikhethiweyo ze-serotonin-reuptake inhibitors (SSRIs) ziye zachaphazela i-serotonin, kodwa ukuqonda okucacileyo kwendima yayo ekuqalekeni kweempawu, ukunyusa, kunye nesisombululo kuhlala kunzima.

Lissemore, JI, et al. (2021). https://doi.org/10.1007/978-3-030-57231-0_13

Nangona singasiqondi isizathu sokuba oku kwenzeke kwi-OCD, ukuvumelana kubonakala ngathi umsebenzi ophantsi we-serotonergic uguqula impendulo ye-orbitofrontal cortex kwaye abantu abane-OCD kufuneka baphathwe nge-agonist ye-serotonin. Kuthekani ukuba bekukho indlela yokuvelisa ukusabela komzimba ngokuthanda ibhalansi ye-serotonin eyayikho hayi i-agonist ye-serotonin ngendlela yeyeza?

Xa sivavanya iinkqubo ze-neurotransmitter ze-dopamine kwizigulana ezine-OCD sidla ngokubona iingxaki nge-dopamine receptors (D2). Kodwa asiboni ulungelelwaniso olubalulekileyo phakathi komsebenzi we-receptor we-D2 ongalunganga kunye nobunzima besifo. Ubuncinci azihambelani kuncwadi. Kodwa siyazi ukuba i-dopamine ibandakanyeka kuba, kuphononongo lwe-pharmacological fMRI yokufunda okomeleza, ukusetyenziswa kwe-dopamine receptor antagonists nge-obsessive-compulsive disorder (OCD) yabona inzuzo yonyango engalindelekanga.

Enye inkqubo ye-neurotransmitter ebonakala ibalulekile kwi-OCD yileyo phakathi kwe-glutamate kunye ne-GABA. I-Glutamate yi-neurotransmitter evuselelayo ebalulekileyo ekusebenzeni okuqhelekileyo kwengqondo, kodwa xa i-balanced ingekho i-neurotoxic. Eyona nto ichazwa njengepedali yegesi. I-GABA yi-neurotransmitter ethintelayo kwaye ngokuqhelekileyo sicinga nge-GABA njengento epholileyo, evakalelwa-yonwabileyo, kungekhona uhlobo oluthile lwe-neurotransmitter xa lulingana. I-GABA inokucingelwa njengeziqhoboshi. Ezi zimbini kufuneka zilungelelane kwingqondo esebenza kakuhle. Kodwa asiziboni ezi zimbini zilinganayo kwi-OCD.

Ukungalingani phakathi kwe-glutamate kunye ne-GABA neurotransmitter iinkqubo kwizakhiwo ezithile zobuchopho kucingelwa ukuba zidale ukuphindaphinda uhlobo lokuziphatha kwezinye iimpawu ze-obsessive-compulsive disorder (OCD). Abanye abaphandi bacinga ukuba i-glutamatergic hyperactivity (ukwenza i-glutamate eninzi) ehambelana nokusebenza ngokugqithiseleyo kweendlela ezithile kunokukhokelela kuphuhliso lwe-OCD. Sinetoni yezifundo zezilwanyana ezineempuku ezibonisa oku kunye nezifundo ezimbini zabantu. Amanqanaba aphakamileyo e-glutamate afunyenwe kuzo zombini izifundo zabo bangakhange baxilongwe kwaye baphethwe yi-obsessive-compulsive disorder (OCD).

Kukho ubungqina obukhulayo obuvela kwizifundo ze-neuroimaging, ezichaphazela ukungasebenzi kakuhle kwe-glutamatergic kwi-OCD. Nangona kunjalo, ubungqina buhlukene malunga nohlobo oluchanekileyo lokungasebenzi.

Karthik, S., Sharma, LP, & Narayanaswamy, JC (2020). Ukuphanda indima ye-glutamate kwi-obsessive-compulsive disorder: iimbono zangoku. 
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7173854/

Akulula nje ukuba kukho "i-glutamate eninzi kakhulu" nangona oko kunokuba njalo kwezinye izakhiwo zengqondo. Ingumba wokungalingani kwe-glutamate. Kuba siphinde sabona ubungqina be-glutamate encinci kakhulu kwithalamus kwabo bane-OCD. Kwakhona, ingqondo yinkqubo entsonkothileyo. Ukuba sizama ukunyanga ngendlela enye kunye nongenelelo ukuze sifumane olo lungelelwaniso. Kwaye kubantu abaninzi abane-OCD, oku akusebenzi.

Amanqanaba asezantsi e-neurotransmitter GABA abonwa enxibelelana nobukhali beempawu eziphezulu kwabo bane-obsessive-compulsive disorder (OCD). I-GABA esezantsi ibonakala ikhona kwi-rostral yangaphambili ye-cingulate cortex, ekucingelwa ukuba inendima kwintsilelo kulawulo lwengqondo esiyibonayo nge-OCD (umzekelo, iingcamango eziphazamisayo).

Kuhlalutyo lwe-meta lwezifundo ze-neuroimaging eziqhutywe ngo-2021, kwafunyaniswa ukuba kukho ukucutha kwe-D2 receptors (i-dopamine), i-GABA receptors, kunye ne-cingulate 5-HT receptors (serotonin). Ezi ntlobo zeziphumo malunga neenkqubo ze-neurotransmitter kwi-OCD zibonelela ngobungqina obuninzi bokuba kukho ukungasebenzi kakuhle kwi-neurotransmitter balancing. Ngaba ukungenelela okuye kwaboniswa ukuphucula ukulinganisa kwe-neurotransmitter, kwiinkqubo ezininzi ze-neurotransmitter, ngokuchasene nenye okanye ezimbini, akufanelekanga ukuxoxwa kunyango lwe-obsessive-compulsive disorder (OCD)?

Ndingathi ewe. Ingxoxo yokutya kwe-ketogenic njengendlela yokulinganisa i-neurotransmitters (kwaye kungekhona nje enye yazo i-willy-nilly) iqinisekisiwe ngokuqinisekileyo.

Ukutya kwe-ketogenic kuphatha njani ukungalingani kwe-neurotransmitter kwingqondo ye-OCD

Imizimba yeKetone yimizimba yomqondiso. Oku kuthetha ukuba bavula kwaye bacime imfuza kwaye bancede ukumisela iinkqubo ezininzi. Enye yazo yi-neurotransmitter balance. Ngokomzekelo, i-acetoacetate, uhlobo oluthile lomzimba we-ketone luyakwazi ukuvimbela ukukhululwa kwe-glutamate kwi-neurons kwezinye iindawo zengqondo kodwa kuya kuphucula ukuhanjiswa kwayo kwezinye iindawo ezifunayo kwaye zifuna. Ngaba unomfanekiso ngqondweni wonyango lwe-psychopharmacological ukwenza oko? Ukukwazi ukunceda ingqondo yakho ukuba iyisebenzise kanye nini kwaye ifuneka phi? Ngaphandle kokuphazamisa ngandlel’ ithile yonke imilinganiselo ngokuzama ukulawula ukuba kwenziwa malini na, okanye ijinga kangaphi kwi-synapses? Andiqondi ukuba akunjalo. Kodwa ii-ketones ziyakwazi ukwenza oko.

Ii-Ketones nazo zineempembelelo ezithathwa ngokungathanga ngqo. Njengoko ii-ketones zidiliza, i-byproducts yazo isetyenziswa kwiinkqubo ezilawula i-neurotransmitter synthesis. Ezi ziphumo ezisezantsi zinempembelelo kwaye zilawula i-neurotransmitters glutamate kunye ne-GABA. Kukho imveliso encinci ye-glutamate kulabo bakwi-ketogenic yokutya, kwaye sibona i-GABA eninzi. Umzekelo, abantwana abakwi-ketogenic diet ye-epilepsy banamanqanaba aphezulu e-cerebrospinal fluid GABA kunamaqela olawulo. Sikwabona oku kwanda okuthandekayo kwi-GABA xa usebenzisa i-magnetic resonance spectroscopy kwizifundo zabantu.

Kodwa kuthekani nge-glutamate? Ewe, siyazi ukuba ukuncipha kwe-neuroinflammation eyenzekayo ngokutya kwe-ketogenic kuphucula imeko apho ingqondo yenza ii-neurotransmitters. Ngelixa siza kufunda ngakumbi malunga nokudumba kamva kule post yebhlog, kufanelekile apha ukuba uqaphele ukuba xa ubuchopho buvutha bunokuphazamisa ukuveliswa kwe-neurotransmitter eqhelekileyo. Kwaye oku kubonwe kwimveliso ye-glutamate, ifikelela kwi-100x ngaphezulu kwemveliso ye-glutamate kunesiqhelo kwingqondo. Ngokucacileyo, oku kuneziphumo ze-neurotoxic. Ngaba bekungayi kuba kuhle ukuba bekukho indlela yokulungelelanisa le nkqubo ye-neurotransmitter?

I-Ketones yenzeke nje ukuphucula ukuguqulwa kwe-glutamate kwi-GABA, enokuba yinxalenye ebalulekileyo yemiphumo yokulinganisa esiyibonayo xa abantu bethatha ukutya kwe-ketogenic. Ngokuphathelele i-serotonin kunye ne-dopamine, sibona iziphumo zokulinganisa ezo neurotransmitters nazo kunye nokutya kwe-ketogenic. Sibona ukunyuswa kwe-serotonin kunye nokulungelelaniswa kwe-dopamine. Sikwabona umsebenzi ophuculweyo we-cell membrane, oya kuphucula indlela ezo neurons zinxibelelana ngayo kwaye zisebenzise ii-neurotransmitters ezenziweyo. Unokufunda ngakumbi malunga noku Apha.

Izidlo ze-Ketogenic zibonelela ukuzinziswa kwe-neuronal membrane. Ukutya kwe-Ketogenic kwandisa amanani kunye nezenzo ze-ATP kunye ne-adenosine. I-ATP (ifuneka ngamandla) kunye ne-adenosine zibalulekile ekuzinzeni kwe-metabolic. I-Adenosine, ngokukodwa, iyaziwa ngokuba yi-neuroprotective kunye nokukhuthaza i-homeostasis (ibhalansi), ukuzinzisa amandla e-membrane yeselula, oyifunayo ukuze wenze umlinganiselo ochanekileyo we-neurotransmitters, ubavumele ukuba bahlale ixesha elifanelekileyo, kwaye bavumele ukuba ziphulwe xa zimelwe kukuba. Akukho ulungelelwaniso oluyimpumelelo lwe-neurotransmitters ngaphandle kokusebenza kwe-cell membrane esempilweni.

Ndingaqhubeka malunga nendlela esingenawo ngayo amayeza e-psychotropic e-OCD, okanye ezinye iziphazamiso, ezibonelela ngoku abantu ngendlela elungeleleneyo. Kodwa andizukuyenza kuba loo nto iya kuba ingekho-kwisihloko kwaye ingcono kwiposti yebhlog yexesha elizayo.

Ingongoma yam ebaluleke kakhulu echaphazelekayo kumfundi wale bhulogi, kukuba ukutya kwe-ketogenic kuphucula umsebenzi we-neuronal membrane kwaye uvumela abamkeli bakho ukuba basebenze ngcono. Ikwakunceda ukuba ugcine ii-cofactors, uphucule amandla enwebu, kunye nentaphane yezinye izibonelelo zobuchopho ezintle endingakhange ndizibone zipapashwa zinokwenzeka nge-psychopharmacology.

OCD kunye neuroinflammation

Ukudumba yinkqubo apho wenzakala khona okanye uhlaselwa ngandlel’ ithile, kwaye umzimba wakho uzama ukuwulungisa. Ikwenza oku nasengqondweni. Engqondweni, i-neuroinflammation inokwenzeka ngenxa yezinto eziwela umqobo ovuzayo wegazi-ingqondo, imizimba ye-neuronal engenawo amandla aneleyo okuzigcina, okanye i-microglial ezama ukukuhlangula njengendlela yokuvuselela amajoni omzimba. Ukudumba okungapheliyo kunye ne-neuroinflammation, ngakumbi, zibonwa kuxilongo lwengqondo kubandakanya ukudakumba kunye nexhala, kunye nemiba ye-neurological njengakwi-dementia. Ke akufanele kusimangalise ukuba sifunde ukuba i-OCD inecandelo elibalulekileyo lokudumba.

I-OCD inxulunyaniswa nokudumba okukwibakala eliphantsi, i-neural antibodies, kunye ne-neuro-inflammatory and auto-immune disorders

Gerentes, M., Pelissolo, A., Rajagopal, K., Tamouza, R., & Hamdani, N. (2019). I-Obsessive-compulsive disorder: i-autoimmunity kunye ne-neuroinflammation. https://doi.org/10.1007/s11920-019-1062-8

Nangona uninzi lwezifundo zifumana ukudumba okuphezulu kwabo bane-obsessive-compulsive disorder (OCD) zithathwa njengemibutho (kukho ubudlelwane kunye nomnye rhoqo), kukho ubungqina obaneleyo bokucebisa ukuba kukho indima kwi-pathogenesis. (indlela isifo esiqala ngayo) ye-OCD. Kukho ubungqina obaneleyo bokuvuvukala okunendima ebangela ukuba kukho ingxoxo kwiincwadi ezicebisa ukuba amayeza achasene nokudumba aphuhliswe kwaye aphinde asetyenziswe unyango lwe-immunomodulatory ukunyanga i-OCD.

Kwaye oko kulunge ngokwaneleyo kum. Ukuba ukuvuvukala yinxalenye ye-OCD ngoko kufuneka siyinyange. Ke mandikuxelele ngeziphumo ezichasene nokudumba kwesidlo se-ketogenic.

Ukutya kwe-ketogenic kuphatha njani ukuvuvukala kubantu abane-OCD

Ukutya kwe-Ketogenic kunciphisa i-neuroinflammation ngeendlela ezahlukeneyo

• kunciphisa umonakalo we-oxidative (siya kufunda ngakumbi malunga noku kungekudala)
• ukuphuculwa kwe-neural energy metabolism (khumbula i-hypometabolism ngasentla?)
• iziphumo ze-epigenetic njengemizimba ebonisayo ehlengahlengisayo okanye ecima iindlela zokudumba (vula nokucima iijini!)
• imiphumo emihle kwi-gut microbiome enciphisa ukuvuvukala

Izidlo ze-Ketogenic zinciphisa ukuvuvukala kuzo zonke ezo ndlela. I-Ketones, eziveliswa emzimbeni ngexesha lokutya kwe-ketogenic, yinto esiyibiza ngokuba yi-molecules yomqondiso. Kwaye imolekyuli ebonisayo inokuguqula ezinye iijini kunye nezinye iijini zivuleke, kwaye kwimeko yokudumba, esi senzo silungele ukudumba OKUNCANE. Ukutya kwe-ketogenic kunika iimeko apho oku kubonakaliswa okufanelekileyo kunokwenzeka. Kodwa kwakhona isicwangciso sokutya esinciphisa okanye esiphelisa iingxaki nge-hyperglycemia.

Unokuba neziqendu ze-hyperglycemia nokuba awunasifo seswekile. Kwaye xa une-hyperglycemia ichaphazela iiseli zomzimba ngendlela ebangela ukudumba okungaphezulu. Awuzenzi ii-ketones ukuba utya iicarbohydrates ezininzi ezibangela i-hyperglycemia, kuba i-hyperglycemia ithetha ukuba une-insulin ephezulu kakhulu, kwaye ii-ketones azenziwa kwezo meko.

Ke ukutya ukutya kwe ketogenic ukuze unyange i-OCD yakho kuya kususa ukudumba okuya kwenzeka xa usitya ukutya okuqhelekileyo kwaseMelika okuphezulu kwiicarbohydrate kunye nokutya okucutshungulweyo. Kuya kunciphisa ukuvuvukala usebenzisa ii-ketones ozenzayo kunye nokufumaneka kwe-micronutrient ephuculweyo ekukhethweni kwakho kokutya ngokutya ukutya okwenziwe kakuhle kwe-ketogenic.

Kuba sixoxa ngendlela enye into eyiphembelela ngayo enye, lixesha elifanelekileyo lokubandakanya esi sicatshulwa singezantsi. Wenza umsebenzi omhle kangaka obonisa ukuba indlela enye kwimpilo yengqondo engeyonkqubo ngokwendalo ayinakuze yanele ukuba sempilweni.

Uphononongo lwakutsha nje lubonisa ukuba iinkqubo zokudumba kunye nokungasebenzi kakuhle kwamajoni omzimba kunokwenzeka ukuba kudlale indima kwi-pathophysiology ye-OCD, ebonisa ukuba ukuphazamiseka kwii-neurotransmitters ezifana ne-serotonin kunye ne-dopamine ayinakuba yodwa ebandakanyekayo kuphuhliso lwe-OCD.

Ghasemi, H., Nomani, H., Sahebkar, A., & Mohammadpour, AH (2020). https://doi.org/10.2174/1570180817999200520122910

Ukunyangwa kwe-Obsessive-compulsive disorder (OCD) usebenzisa ukutya kwe-ketogenic nako kuphucula ukusebenza kwe-immune system. Njengoko sibona kwisicatshulwa esi ngasentla, inkqubo yokuvuvukala iqhutywe ngokuyinxalenye yi-immune system dysfunction. Uphando lucebise ngamandla ukuba umsebenzi wokhuselo lomzimba uphucula kakhulu kukutya kwe ketogenic. Iziphumo zokutya kwe-ketogenic ekusebenzeni kwamajoni omzimba zilungile kangangokuba kwinqaku lakutshanje kuye kwacetywa ukusetyenziswa kwi-COVID-19 njengonyango lothintelo. Kusenokwenzeka ukuba ukuphuculwa kokusebenza kwamajoni omzimba kunokuba luncedo ekunciphiseni ukudumba okukhoyo kwiingqondo zabo banengxaki yokunyanzelwa yi-obsessive-compulsive disorder (OCD). Umntu one-OCD unokufuna ukusebenzisa ukutya kwe-ketogenic kule njongo endaweni yamayeza.

I-OCD kunye noxinzelelo lwe-Oxidative

Uxinzelelo lwe-oxidative lwenzeka xa amandla engqondo okuzigcina okanye ukuzikhusela ekuhlaselweni kungasanele. Oku kunokwenzeka kwiivenkile ezingonelanga ze-micronutrient, iimpendulo ze-immune system, okanye i-toxins eyenza ibe ngumqobo ovuzayo wegazi-ubuchopho. Izizathu ezingenakubalwa ngokwenene. Ukuphila nje kudala uxinzelelo lwe-oxidative. Kukho umzobo obalaseleyo obonisa izinto ezahlukeneyo ezinxulumene noxinzelelo lwe-oxidative Apha (ngokuqinisekileyo ilungile ngokwenene, yijonge).

Kodwa ingqondo kunye nomzimba osempilweni ziyakwazi ukulwa nolu hlaselo zisebenzisa eyethu imveliso ye-antioxidant. Kodwa kubantu abane-obsessive-compulsive disorder, oku ngokucacileyo akwenzeki kwinqanaba elaneleyo.

Izifundo zamva nje zibonise umsebenzi omninzi we-radical metabolism yasimahla kunye nobuthathaka benkqubo yokukhusela i-antioxidant kwi-OCD.

Baratzadeh, F., Elasi, S., Mohammadpour, AH, Salari, S., & Sahebkar, A. (2021). Indima yee-Antioxidants kuLawulo lwe-Obsessive-Compulsive Disorder. https://doi.org/10.1155/2021/6661514

Uxinzelelo lwe-oxidative lunendima eyomeleleyo kwi-OCD, loo ngxoxo yenziwe ngokusetyenziswa kwe-antioxidant zonyango kunyango lwayo. Kodwa yintoni abantu abaninzi abangayicingiyo indima ye-ketones ekuncedeni abantu bakwazi ukusebenzisa iinkqubo zabo ze-antioxidant emzimbeni. Ngoko masiyixubushe loo nto ngokulandelayo.

Ukutya kwe-ketogenic kuluphatha njani uxinzelelo lwe-oxidative kwabo bane-OCD?

Kulungile, masijonge kumfanekiso endikucebise ukuba ujonge kuwo ngaphambili. Kulunge kakhulu ukuba singasebenzisi kwingcaciso yethu.

Sele sisazi kwizifundo zethu ukuba ukutya kwe-ketogenic kulawula i-mitochondria kunye nomsebenzi we-mitochondrial. Ke siyazi ukuba ukutya kwe-ketogenic kuya kuthintela ukungasebenzi kakuhle kwe-mitochondrial esiyibonayo kulo mfanekiso into ebangela uxinzelelo lwe-oxidative.

Yintoni eyenziwa yi-mitochondria?

Siphinde safunda indlela ukutya kwe ketogenic kuphucula umsebenzi we-neuronal membrane. Sibona kulo mfanekiso ukuba ukungasebenzi kakuhle kwe-neuronal membrane kunegalelo njani kuxinzelelo lwe-oxidative. Ke ukutya kwe-ketogenic kunokugcina kakhulu le nto inegalelo kuxinzelelo lwe-oxidative ukuba lwenzeke kwindawo yokuqala.

Siye saxoxa ngendlela ii-ketones ezibonisa ngayo imizimba, ekwazi ukuthobisa ukudumba ngokuba nefuthe eliluncedo kakhulu kwiindlela zokudumba. Oku akuyontelekelelo kum. Ikuncwadi kwaye inikezelwe kwinqanaba elithile kuluhlu lwereferensi olungezantsi. Izidlo ze-Ketogenic zingenelelo ezinamandla zokuvuvukala. Kwaye ukuba sinokugcina ukuvuvukala kuphantsi, sigcina uxinzelelo lwe-oxidative luphantsi esilubona kwiingqondo ze-OCD.

Le yimiba yonke enomdla kakhulu kwaye ibonisa ukuba izidlo ze-ketogenic zinamandla kakhulu, ungenelelo olubanzi olusebenzayo. Kodwa icandelo lomzobo endithanda ukugxila kulo xa ndifundisa abantu ngoxinzelelo lwe-oxidative kunye nefuthe lalo kukuphazamiseka kwengqondo kubhekiselele kule bhokisi ilapha:

Ndikholelwa ngokuqinileyo kumandla e-endogenous (umzimba wakho uyenza, awuwutyi okanye awuginye njengesongezelelo) i-antioxidants. Kwaye eyona inamandla oyenzayo, phantsi kweemeko ezifanelekileyo, i-glutathione. I-Glutathione sisisithintelo esinamandla kakhulu kwaye ii-ketones zidlala indima kubuchule bomzimba wakho bokuyenza kunye nokuyisebenzisa kakuhle.

I-Ketones zineempawu ze-neuroprotective eziphazamisa ukubunjwa kweentlobo ze-oxidant ezisebenzayo ezidala uxinzelelo lwe-oxidative kwaye zikwaluncedo ekuncedeni ibhalansi ye-metabolism yamandla ngendlela yokuba ithande ukutshatyalaliswa kweemveliso ze-oxidative ngokusebenzisa i-glutathione.

Ukutya kwe-ketogenic eyenziwe kakuhle nako kunomsoco kwaye kuya kukuvumela ukuba ukhulise kwaye ugcine (ngenxa yokuphucula umsebenzi we-membrane) ezo micronutrients ezifunekayo ukwenza i-glutathione kwindawo yokuqala.

Ngaba uyayifumana?

Akuyomfuneko ukuba utye imifuno kunye neziqhamo ezinombala we-rainbow okanye uthathe ivithamin C eninzi okanye i-E. Unokuba nokutya okutyebileyo okunezondlo ezibonelela ngeebhloko zokwakha ukwenza eyona antioxidant inamandla esiyaziyo, emzimbeni wakho. , kwaye ke usebenzise iiketoni ukuvula amandla azo.

Kwaye oku kunokukunceda ukulwa kunye / okanye ukuphelisa ngokupheleleyo uxinzelelo lwe-oxidative okwangoku ukwandisa iimpawu zakho ze-obsessive-compulsive disorder.

Ziziphi ezinye iindlela ezenza ukuba ukutya kwe-ketogenic kuncede i-OCD?

Izidlo ze-Ketogenic zenza izinto ezininzi ezintle kwingqondo ekubandezelekeni, nakwingqondo ye-OCD ngokukodwa. Kodwa kukho enye into efanele ikhankanywe ngokwenene.

I-Ketones ilawula i-brain-derived neurotrophic factor (BDNF). Kutheni le nto ibalulekile kumntu ophethwe yi-OCD? Ewe, zininzi izizathu. Kodwa kuqala, masiqale ngokuthi inxalenye yesiphumo sonyango esibonwa ngabanye abantu ekusebenziseni ii-SSRIs ze-OCD kukuba la machiza anyusa i-BDNF. Sizisebenzisela ukwenzakala kwengqondo ngenxa yesi sizathu. Ngaba baya kuyilawula ngokukhawuleza njengokutya kwe-ketogenic? Andicingi njalo kodwa andinayo idatha yokuxhasa okanye ukuphikisa loo ngcinga. Ndiyikhankanya apha kuba ndifuna ukuba uqonde ukuba i-BDNF iluncedo ekubuyiseni kwakho kwi-obsessive-compulsive disorder (OCD).

I-BDNF yeyona nto iya kukunceda ukuba udibanise ezo zakhiwo zengqondo ngeendlela ezintsha nezisempilweni. I-BDNF yinto eza kukunceda ufumane okuninzi kumsebenzi wokuthintela ukuchaswa kwe-exposure-response (ERP) owenzayo nomgqirha wakho. Ngaba ufuna ukufunda iindlela ezintsha zokucinga kunye nokuba ngelixa usenza unyango lwe-cognitive-behavior for OCD yakho? I-BDNF iyafuneka. Kwaye ii-ketones zigqwesileyo ekwandiseni inani le-BDNF kwingqondo yakho, enokukunceda kuphela kwaye enye indlela yokutya kwe-ketogenic ingaba ngumncedi kumsebenzi we-psychotherapy. Ngoko ngelixa i-BDNF ayikho enye yezinto ezine endihlala ndibhala ngazo xa ndixubusha ukutya kwe-ketogenic njengonyango lwesifo sengqondo, ifanelwe ukukhankanywa okunamandla kunye nokuhloniphekileyo.

isiphelo

Ithemba lam elinyanisekileyo lokuba uqala ukubona ukuba zonke iinqununu zesenzo kwi-ketogenic diet zisebenza kunye. Ukuba ufumene ukuqonda ukuba ukuphucula i-neuroinflammation kunciphisa uxinzelelo lwe-oxidative. Uxinzelelo oluncinci lwe-oxidative luphucula imeko apho ubuchopho benza kunye nokulinganisa ii-transmitter kunye nokuphucula imisebenzi ebalulekileyo ye-membrane. Ukuba ngoku uyaqonda ukuba ukuncitshiswa kwe-neuroinflammation kunye noxinzelelo lwe-oxidative kuthetha ukuba zimbalwa izondlo eziphelelwayo, kunye nezandulela ezifumanekayo zokwenza izinto ezibalulekileyo, njengokwenza i-enzymes kunye ne-neurotransmitters. Ndiyathemba ukuba kucacile ukuba i-neurons yamandla ephuculweyo ifumana kwi-ketogenic diet ivumela ukuba isebenze ngcono ngokubanzi. Kwaye ukuba amandla aphuculweyo ezi seli kunye nokunyuswa kwe-BDNF ivumela ezo neuron ezifanayo ukuba zenze ugcino olusisiseko olufunekayo ukuze zihlale zilungiswa kakuhle kwaye zenze uqhagamshelwano olutsha lokufunda.

Ukuba usazama ukufunda umahluko phakathi koxinzelelo lwe-oxidative kunye neuroinflammation kunye nendlela ezinxulumene ngayo, eli nqaku lingezantsi liluncedo!

Ukuba ubuchopho bakho besisiXeko: Ukuqonda uxinzelelo lwe-Oxidative kunye ne-Neuroinflammation

Kwakhona, akukho zilingo zeklinikhi ezingahleliweyo okwangoku zisebenzisa ukutya kwe-ketogenic ngokukodwa ukunyanga i-obsessive-compulsive disorder (OCD). Sinokongeza kuphela izibonelelo ezinokuthi zibekho kolu luntu ngokusekwe kwiziphumo ezibonwe kwezinye izifo ze-neuropsychiatric kunye ne-neurological. Sinokuvuleleka kwingcamango yokuba ungenelelo olubonwayo lokunciphisa uxinzelelo lwe-oxidative kwindawo enye okanye ezininzi ezahlukeneyo, zombini kwimodeli yezilwanyana kunye nabantu, kunokukwenza ngempumelelo oko kwi-OCD. Kufuneka ubuncinane sixoxe ngokunokwenzeka kwaye okona kubaluleke kakhulu, sikwazise ngaloo nto inokwenzeka. Ngoko ke unokwenza ezona zigqibo zonyango zilungileyo zisengqiqweni kuwe!

Ndifuna ukukukhuthaza ukuba ufunde ngakumbi malunga nokhetho lwakho lonyango nakweyiphi na kwezi zilandelayo izithuba blog. Ndibhala malunga neendlela ezahlukeneyo kumanqanaba ahlukeneyo eenkcukacha onokuzifumana ziluncedo ukufunda kuhambo lwakho lwempilo. Ungayonwabela i Izifundo zeKetogenic iphepha lokufunda indlela abanye abaye basebenzisa ngayo ukutya kwe-ketogenic ukunyanga ukugula ngengqondo ekusebenzeni kwam. Kwaye unokuzuza ngokuqonda ukuba ukusebenza nomcebisi wezempilo yengqondo ngelixa utshintshela kwi-ketogenic yokutya kunokuba luncedo. Apha.

Yabelana ngesi sithuba sebhlog okanye abanye nabahlobo kunye nosapho olunengxaki yokugula ngengqondo. Abantu mabazi ukuba likho ithemba.

Unokufunda ngakumbi ngam Apha.

Unokuxhamla kwinkqubo yam ye-intanethi eyilelwe ukukufundisa indlela yokuphumeza ukutya kwe-ketogenic, uqhube olwakho uvavanyo lwe-nutrigenomics ukwenza ukongeza kwakho kwaye ufumane uqeqesho lwezempilo olusebenzayo.

Inkqubo yoBuyiselo lweNkungu yengqondo

Ndiyakholelwa ngokwenene ukuba unelungelo lokwazi zonke iindlela onokuziva ngcono ngazo.

Njengale nto ufundayo kwibhlog? Ngaba uyafuna ukufunda malunga neewebinars ezizayo, iikhosi, kunye nokubonelela ngenkxaso kunye nokusebenza nam kwiinjongo zakho zempilo? sayina!

https://mentalhealthketo.com/free-ebook/

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Ucaphulo

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