Ukutya kwe-ketogenic kunokunceda njani ukuphilisa ingqondo evuzayo kwaye yenze umqobo wegazi-ubuchopho womelele kwaye womelele ngakumbi?
Ixesha lokufunda eliqikelelweyo: 17 imizuzu
Ngumbuzo olungileyo ngenene lowo. Ngoko ke ndiza kuyiphendula. Kule post yebhlog, siza kuxoxa ukuba yintoni isithintelo segazi-ingqondo, zeziphi iimpawu esinokulindela ukuba zenzeke ukuba zonakele kwaye zivuza, kunye novavanyo lwaselebhu olunokuthi lusetyenziswe ukuzama ukuvavanya ukuba luyavuza.
Umqobo wakho wegazi ebuchotsheni (BBB) ubaluleke kakhulu.
Okokuqala, intwana nje ye-anatomy kunye nomsebenzi. Kwanele nje ukuze uqonde okubandakanyekayo.
I-BBB ihlukanisa igazi kwi-extracellular cerebrospinal fluid kwaye ikhusela ingqondo kwi-pathogens enegazi kunye ne-toxins ngelixa ivumela ukusasazwa kwe-oksijini, i-carbon dioxide, kunye ne-lipophilic molecules / i-ethanol encinci. Ugcino lwe-BBB lubalulekile kulawulo oluluqilima lwemichiza yolwelo lwengqondo lwe-interstitial fluid (ISF) oluyimfuneko ekusebenzeni kwe-synaptic kunye nokubonelela ngohlobo lokhuseleko kwiintsholongwane zegazi.
Kakaroubas, N., Brennan, S., Keon, M., & Saksena, NK (2019). I-Pathomechanism yokuphazamiseka kwesithintelo segazi-ingqondo kwi-ALS. Ijenali yeNeuroscience, 2019. https://doi.org/10.1155/2019/2537698
I-BBB yingqokelela yemithambo yegazi kunye nee-astrocyte ezithi kunye zigcine izinto zingekho kwingqondo kwi-systemic circulation. Inabathuthi abohlukeneyo abavumela ukuba ezinye izinto zidlule.
Kodwa njengethumbu elivuzayo njengoko i-BBB isihla empilweni ayinako ukugcina ingqibelelo yayo kwaye izinto zingena ebuchotsheni obungafanelekanga. Oku kunokubandakanya:
- Iikhemikhali kunye neeToxin zeNdalo
- Iintsholongwane (iintsholongwane kunye neentsholongwane)
- Iiprotheyini zokutya (umzekelo, igluten)
- Abalamli abahlukeneyo abadumba egazini (umzekelo, i-lipopolysaccharide)
- Ii-anti-bodys ezijikelezayo
- Ukungalingani kweHormone (i-hypothyroidism yokwenyani)
Xa ezi zinto zingena kumqobo ovuzayo wegazi-ingqondo zivula amajoni omzimba obuchopho ukuzama ukukhusela ingqondo. Ngokukodwa, iiseli ze-microglial ziyasebenza. Ukuba une-BBB evuzayo, oko kuthetha ukuba izinto zinyuka ngalo lonke ixesha ezingezizo ezakhe. Kwaye oku kuthetha ukuba ukusebenza kwe-microglial kwenzeka rhoqo. Akulunganga oko. Oko kubeka inqanaba le-neuroinflammation engapheliyo. Kwaye ukuba ingqondo yakho ayikwazi ukuzilungisa ngokukhawuleza ngokwaneleyo ukuze ihambisane nomonakalo oqhubekayo kwi-neuroinflammation engapheliyo, izakumisela inkqubo ye-neurodeergenerative.
Ubuchopho bufuna i-micronutrients ukulungisa umonakalo, ukwenza i-neurotransmitters kunye nee-enzyme ezibalulekileyo, kunye nokuvelisa amandla. Ngaba uyazi ukuba ingqondo yakho ifumana njani uninzi lweevithamini ezifunekayo kwezo nkqubo? I-BBB yakho. Ewe, kunjalo! Uninzi lweevithamini eziyimfuneko ezinyibilikayo emanzini (umzekelo, iivithamini ze-B) kunye nezinye i-metabolites ezibalulekileyo zihanjiswa kwingqondo kusetyenziswa abathuthi abathile kwi-BBB.
Ezinye zezi zithuthi zisetyenziselwa ukuhambisa iswekile ebuchotsheni. Njengoko siye saxubusha kumanqaku angaphambili, oku akufuneki ukuba ibe yi-glucose oyityayo. Umzimba wakho uyavuya kakhulu ukwenza i-glucose substrate oyifunayo ukuze iindawo ezithile zengqondo yakho zisebenze. Kodwa ukuba i-BBB yakho yonakele kwaye abathuthi abasetyenziselwa loo njongo bonakaliswe okanye bangasebenzi (i-BBB inokumelana ne-insulin) ngoko awuyi kufumana ukusebenzisa loo glucose yamandla. Kwaye ngale ndlela, ukuwohloka kwe-BBB kunokwenzeka kwaye ukuwohloka kwayo kunokuqhubela phambili iingxaki zamandla kwingqondo.
Ukuba i-BBB yakho yonakele, oko kunokubangela ingxaki kubo bonke abo bathuthi, umsebenzi wabo kukufumana izondlo kunye namafutha kwingqondo yakho.
Oku kuthetha ukuba ingqondo yakho iguga KAKHULU ngokukhawuleza kunokuba ubufanele ukuba njalo. Kwaye akukhathaliseki nokuba una 15 okanye 27 okanye 34 okanye 40s okanye 50s okanye 60s. Iinkqubo ze-neurodeergenerative zenzeka nakweyiphi na iminyaka. I-BBB evuzayo ayiyongxaki yomntu omdala. “Nguye wonke umntu walo naluphi na uhlobo lwengxaki yobudala.” Kwaye kufuneka iqwalaselwe kwaye iqwalaselwe.
Ungandivi kakubi. Ndiyavuya ukubona iGUT evuzayo ifumana i-airtime eninzi kunye nenkxalabo. Ndixolile ekugqibeleni kwi-radars zabantu ngendlela yokwenyani. Ukuphilisa amathumbu avuzayo kubalulekile kuba kufuneka ugcine amajoni omzimba ethe cwaka ukuze amajoni obuchopho angasebenzi ngokugqithisileyo. Udinga amaphecana okwetyisa asempilweni ukuze ukwazi ukwaphula kwaye ufunxe izondlo zakho ngamathumbu akho kwaye udinga i-microbiome esempilweni mhlawumbi ngezizathu zebhiliyoni.
Unokufunda ngakumbi malunga nee-microbiomes ezisempilweni Apha.
Kodwa kukho omnye umqobo omele ukhuthazwe kwaye uqondwe luluntu ngokubanzi kunye nabantu abalwa nengqondo engasebenzi kakuhle njengoko bengathanda. Yiyo loo nto esi sithuba sibhalwayo. Ingqondo evuzayo yinto.
Xa i-BBB yaphukile eyona nto iphambili eyenzekayo kukuba ufumana i-neuroinflammation. Xa kukho inkqubo ye-neuroinflammatory, abantu baqala ukukhalaza ngokuba neempawu zenkungu yengqondo.
Xa unenkungu yobuchopho, oko kuthetha ukuba kukho into ephazamisana nomsebenzi oqhelekileyo we-synapse.
Ii-synapses zenza inxalenye ekhethekileyo kunye nebalulekileyo yeeseli ze-neuronal. Zizona ndawo eziphambili zokunxibelelana phakathi kweeseli ze-neuronal, kwaye ngoko ke, zibandakanyeka kuzo zonke iinkalo ze-neuronal physiology. Umsebenzi ofanelekileyo we-synaptic uyimfuneko yokusebenza kwengqondo eqhelekileyo, kwaye nokuphazamiseka okuncinci kunokukhokelela kwingxaki ye-neurological.
Xylaki, M., Atzler, B., & Outeiro, TF (2019). I-Epigenetics ye-Synapse kwi-Neurodegeneration. I-neurology yangoku kunye neengxelo ze-neuroscience, 19(10), 1-10. https://doi.org/10.1007/s11910-019-0995-y
I-Neuroinflammation iphazamisa isantya se-nerve conduction kwaye unokuqaphela ukuba ukucinga kunye nemisebenzi yemoto iyancipha okanye ifike ngokulula. I-Neuroinflammation nayo "idibanisa" i-mitochondria. I-Mitochondria zizindlu zakho zamandla kwiiseli. Zinika amandla iseli yakho iwadinga ukuze isebenze. Ukusuka ekudubuleni ezo synapses ukuya ekugcineni iseli isempilweni namandla okwenza isiseko sogcino lwendlu. Iva njani imitochondria engadityaniswanga? Kuvakala ngathi kukudinwa kwengqondo. Ingqondo yakho ikhawuleza idinwe. Mhlawumbi awusakwazi ukuqhuba kwitrafikhi enzima, ukumelana nonxibelelwano olude okanye ufunde kangangoko ubuqhele ukwenza. Ukukwazi kwakho ukwenza imisebenzi kunye nokunikela ingqalelo kuyancipha.
I-Neuroinflammation inokunyuka kwaye iyancipha. Ezinye iiveki kukho ukuphazamiseka kwengqondo kunye nokuphazamiseka kwengqondo, kwaye ezinye iiveki uya kuba namava amancinci kwezo mpawu. Oku kuthetha ukuba ingqondo inempumelelo ethile, ngamanye amaxesha, ukulawula inkqubo yokuvuvukala kunye nokulungisa i-neurodegeneration njengoko isenzeka.
Kodwa njengoko unokucinga, iingcambu ezibangela i-BBB evuzayo akufuneki zingahoywa, kwaye ngaxa lithile inkungu yengqondo inokuba yinto engapheliyo, njengoko amajoni omzimba ahlala esebenza ngokugqithisileyo kwaye nesantya somonakalo owenziweyo sodlula iinkqubo zomzimba zokulwa ne-antioxidant. , ukudala uxinzelelo lwe-oxidative kunye nokumisela iinkqubo ezibalulekileyo ze-neurodeergenerative.
Ubungqina obukhulayo bubonisa ukuba uxinzelelo lwe-oxidative (OS) ludlala indima ebalulekileyo ekufakweni kweenguqu ze-BBB.
Kadry, H., Noorani, B., Bickel, U., Abbruscato, TJ, & Cucullo, L. (2021). Uvavanyo oluthelekisayo lwe-in vitro BBB tight junction imfezeko emva kokuvezwa kumsi wecuba kunye nomphunga we-e-cigarette: Uvavanyo lobungakanani beziphumo ezikhuselayo ze-metformin zisebenzisa iimpawu ezincinci ze-molecular-weight paracellular markers. Ulwelo kunye nezithintelo ze-CNS, 18(1), 1-15. https://doi.org/10.1186/s12987-021-00261-4
Ndihlala ndikhankanya ezi "nkqubo" ze-neurodeergenerative kuba ngelixa i-neurodegeneration ngamaxesha athile isenzeka, xa inyuka ibe yinto engapheliyo (aka inkqubo) i-neurodegeneration izondla ngokwayo, idala i-loop yomonakalo oqhubekayo, ukuncipha kwezondlo, i-neuroinflammation eyongezelelweyo, kunye nezinye izinto ezinokuyenza. kunzima kakhulu ukuyijika emva kwendawo ethile yomonakalo. Ukuba kuvunyelwe ukuba kungakhange kuhlolwe kunokubangela inqanaba lomonakalo ongenakulungiswa. Yiyo loo nto le bhlog ivakala i-alam yokuba inkungu yobuchopho kufuneka ithathelwe ingqalelo kwaye iphathwe ngezondlo ezinamandla kunye nonyango lwengqondo olusebenzayo olumisa oonobangela benkqubo ye-neurodeergenerative. Kungakhathaliseki isizathu okanye ukuxilongwa.
Ndazi njani ukuba ndinobuchopho obuvuzayo?
Kukho iziphawuli ezahlukeneyo ze-antibody ezinxulumene ne-BBB yokungena. Ezi ziquka i-S100B, i-aquaporin 4, i-glial fibrillary acidic protein, kunye ne-zonulin antibodies. Ugqirha wakho osebenzayo unoku-odola iimvavanyo ezinje ngeCyrus Laboratory.
Ungavavanywa, kodwa nantsi into. Ukuba uyazi ukuba unethumbu elivuzayo, okanye ufunyaniswe ukuba unamathumbu avuzayo, maninzi amathuba okuba ube ne-BBB evuzayo. Ngenxa yokuba ithumbu elivuzayo livumela izinto ukuba zingene kwigazi elingafanelekanga. Kwaye ezinye zezo zinto luhlaselo oluthe ngqo kwi-BBB. Unxulumano phakathi kwamathumbu avuzayo kunye ne-BBB evuzayo luphezulu kakhulu. Bahamba kunye.
Ngokomzekelo, ii-antibodies eziveliswa ngokuchasene ne-gluten, ezingayekwanga yi-BBB zinokubophelela kwi-astrocytes kunye neeprotheni ze-neurofilament kwi-cerebellum kwaye zibangele imeko ebizwa ngokuba yi-Gluten Ataxia. Inkqubo ye-neurodeergenerative ekhokelela kolu xilongo inokujongeka njengeempawu zenkungu yobuchopho ezibandakanya ukuthetha ingxaki, ukuntyiloza okungaqhelekanga kwincam, ulungelelwaniso olubi kunye nolungelelwaniso, kwaye mhlawumbi iingxaki usebenzisa iingalo nemilenze okanye iminwe nezandla zakho (umzekelo, uqala qaphela iingxaki ezininzi zokufumana iminwe yakho isebenze ngelixa ukrola).
Mhlawumbi uneetyhefu emzimbeni wakho, nokuba kukuvezwa kwikhemikhali evela kwimveliso yasekhaya eqhelekileyo okanye into oyiphefumleleyo ukusuka kwindawo okuyo uhamba esitratweni (oku kwenzeka rhoqo). Ukuba i-BBB yakho isempilweni, ezi azizukuwela ziye engqondweni. Kodwa ukuba ayisempilweni, nokuba yintoni na enokuthi iyiwelele ebuchotsheni, ivule i-microglia ekhupha iicytokines ezikralayo.
Ezi zinto zingamkelekanga ziyenze nge-BBB yakho, kwaye akufuneki zibe naphina kufutshane nengqondo, ziya kubophelela kwaye zincamathele kwiiprotheni ezahlukeneyo kwaye zaphule izinto. Ndithetha ukuthini xa ndisithi “zaphula izinto” kanye? Ndiyathetha ukuba baya kubophelela kwiindawo ezinye izinto ebekumele ukuba zibophelele kuzo, kwaye zingavumeli into ukuba isebenze kakuhle. Baza kungena endleleni kwaye bathintele iindlela ezibalulekileyo ekufuneka ingqondo yakho isebenze kwaye ugcine ingqondo yakho isempilweni.
Yavuza njani iBBB yakho
I-BBB yakho ziiseli ze-endothelial kunye ne-astrocytes (astroglia). Zombini ezi zinto zonakaliswa lula kwiindawo zokudumba okungapheliyo. Izifo ezingapheliyo ezandisa ukuvuvukala emzimbeni (okuthi mhlawumbi zonke) zinokudlala indima ekuphuleni i-BBB. Amanye amayeza asetyenziswa liyeza eliqhelekileyo ukunyanga isifo esingapheliyo anokubangela ukophuka kwe-BBB (umz., i-corticosteroids). Isenokwenzeka kwakhona ngenxa yokwenzakala kwengqondo (TBI) (umzekelo, iingozi zemoto, ukuwa) kuba i-BBB inokungaphili ngokwaneleyo emva kohlaselo olunjalo. Iingxaki ezingapheliyo zesisu ezivuthayo zingenza imeko yokuvuvukala kwenkqubo ngenxa ye-gut evuzayo (i-permeability) ikhupha i-zonulin okanye i-lipopolysaccharides (LPS) kwigazi, nto leyo ephazamisa impilo ye-BBB ngokuthe ngqo.
Yintoni enye ebangela iingxaki kwi-BBB yam?
Ukuba unamanqanaba aphezulu e-homocysteine kuvavanyo lwakho lwegazi, unethuba eliphezulu lokuba i-BBB yakho iyavuza. Ukuba une-SNP yofuzo efana ne-MTHFR, usengozini ephezulu yeengxaki zokugcina i-BBB yakho icocekile kwaye isempilweni. Unokuphucula amathuba ngokuthatha i-methylated B-complex.
Ezinye izinto ezenza i-BBB ikwazi ukungena zibandakanya oku kulandelayo:
- Indlela yokuphila
- Ukusela utywala
- Ukuncipha kokulala okungapheliyo
Mhlawumbi ungathanda ukwazi ukuba yintoni enokwenziwa ukuyilungisa.
Ukutya kwe ketogenic kunokunceda njani ukuphilisa ingqondo evuzayo
Uninzi lolwazi lwethu malunga nendlela iiketoni ezichaphazela ngayo i-BBB zivela kwizifundo zezilwanyana. Mna ngokwam, iyandikhulula loo nto. Andifuni mntu ucanda entlokweni yomntu ezama ukuqonda ukuba kuqhubeka ntoni apho. Ke musa ukuxhonywa kwingcinga yokuba ngenxa yokuba ezi ziphuma kwizifundo zezilwanyana ngandlela thile iziphumo azikho semthethweni kwi-BBB yakho. Baninzi oomatshini abafanayo abaqhubekayo.
Ukuphuculwa kwengqondo kunye ne-BBB metabolism
Xa umzimba wakho wenza ii-ketones kwi-ketogenic diet, inokubonelela ngomthombo wamandla ongomnye we-BBB eyonakalisiweyo. Zenzeka nje ukuba zibe ngumthombo wamafutha okhethiweyo wengqondo. Bangena ebuchotsheni ngaphandle kwengxubusho okanye unxunguphalo lokufuna isithuthi esonwabileyo okanye esisebenzayo (umzekelo, ukusasaza olulula okanye ukusasaza lula). Abathuthi be-Monocarboxylate balamla ukungena komzimba we-ketone ebuchotsheni, kwaye zininzi kuyo yonke i-BBB, kubandakanywa neplasma inwebu ye-choroid plexus, i-endothelial kunye neeseli ze-epithelial, i-glia, kunye ne-neurons. Ngokwenyani, ii-oodles zeendlela zokufumana ezo ketoni phezulu ukuze ziphembelele ingqondo yakho. Ezo ketone zisetyenziswa kwi-mitochondrial matrix (i-membrane kwiibhetri zakho zeseli) eyenza amandla.
Nantsi into endifuna ukuba uyifumane nawe. I-BBB isebenzisa amandla asuka kwi-ketones nayo. Ezo seli zincinci ezenza i-BBB zizama ukwenza amandla azo asekelwe kwi-ketone ngalo lonke ixesha. Kwaye ukuba ukwisidlo se-ketogenic ezo seli ziza kuzala ngamandla afunekayo ukuze ziqinise iindawo ezidityanisiweyo ukugcina i-BBB yomelele kwaye yomelele.
Ngaba ndithe ubuchopho bufuna amandla amaninzi? Pretty cool ukuba kukho indlela yokuwufumana amandla efunekayo ukuba akudingi mzamo ngakumbi. Kunene? Yinto efana nongeniso lwengeniso endaweni yokuthenga kwinkcubeko ephithizelayo. Ndiyathetha, sinokufumana ezo receptor ze-GLUT zisebenze kwakhona ekugqibeleni njengoko ukuphiliswa kwethu kuqhubeka. Kodwa asinakuze siqhubele phambili ekuphiliseni kwethu ukuba silambisa ingqondo okwangoku. Iza kuqhubela phambili iinkqubo ze-neurodeergenerative eziqhubekayo. Njengebhonasi, imizimba ye-ketone iphinda ikhulise ngokuthe ngqo umsebenzi we-GLUT1, kwaye i-GLUT1 sisithuthi esinceda ukuba iswekile ifike apho ikhoyo.
I-Ketones i-anti-inflammatory
Asinalo iyeza elibonelela ngenqanaba elifanayo leempembelelo ezichasayo ngokukhuselekileyo okanye ngokufanelekileyo njengokutya kwe-ketogenic.
Ukuphumelela konyango lwamachiza amakhulu achasene ne-neuroinflammatory kunqunyelwe yimiphumo yabo engathandekiyo emva kokunyanzeliswa kwe-immunosuppression okwethutyana.
JANIGRO, D. (2022). Iimpembelelo ze-Ketogenic Diet kwi-Blood-Brain Barrier. Ukutya kwe-Ketogenic kunye noNyango lweMetabolic: Iindima ezongeziweyo kwiMpilo kunye neZifo, 346. P.355
Xa kukho ukusebenza okungapheliyo komzimba kukho umonakalo owenziwe engqondweni nakwi-BBB. Oku kubangela ukuvuvukala kunye noxinzelelo olongezelelweyo lomzimba ekuzameni ukugcina ukudibanisa okuqinileyo kwi-BBB. Oku kuvutha kungonakalisa ezo zakhiwo ezibalulekileyo ze-vascular eziyingxenye ye-BBB. Ingonakalisa i-glial kunye ne-astrocytes. Izidlo ze-Ketogenic zinciphisa ukuvuvukala. Ii-ketones eziveliswa kwi-ketogenic diet ziziphatha njengeemolekyuli zokubonisa, ngokoqobo ukuxelela iigenes ezibandakanyekayo ekudumbeni okungapheliyo ukuba zicime. Iluncedo kakhulu ekuncedeni laa BBB incinci ukuba ifumane ukulungiswa, igcine ingqibelelo kunye nokusebenza kwayo, kwaye iqhubele phambili impiliso yayo ukuba uyandibuza.
Ngoku buyela kwezo zakhiwo ze-vascular. Kukho uninzi lwe-dementia enamalungu esifo se-vascular. I-Ketones yandisa ukufunyanwa kwegazi le-cerebral kwaye oku kwandisa ukuhamba kwegazi kunye nokusetyenziswa kwe-oksijini kucingelwa ukuba negalelo kwimiphumo ebhaliweyo ye-neuroprotective yemizimba ye-ketone. I-BBB evuzayo yimeko ye-etiological kwi-dementias ethile (umzekelo, i-Alzheimer's) kwaye kucingelwa ukuba izibonelelo ezibonwa ngokutya okune-ketogenic kwaba bantu ngokuyinxenye zinokuba ngenxa yokuphuculwa komsebenzi we-BBB. I-hypothesis yokuba ii-ketones ziphucula umsebenzi we-neurovascular kwi-dementias yindawo yangoku yophando lophando.
Ngokungathi konke oku akuqiqi ngokwaneleyo ekusebenziseni ukutya kwe-ketogenic ukunceda ukuphilisa ingqondo evuzayo, iiketoni zinceda ekudaleni iiproteni ezininzi ezisetyenziswa yi-BBB ukunyanga ezo ziphambuka zivuzayo, ukuqala.
Iinketho zoKwongeza
Ngenxa yokuba ndikholelwa ukuba unelungelo lokwazi zonke iindlela onokuziva ngcono ngazo, ndiza kudwelisa ezinye zezongezelelo ezisetyenziswayo ezinamaqondo ahlukeneyo obungqina bokuphucula i-BBB. Kodwa mandicace gca kuba andicingi ukuba le ndawo ikufuphi nepholileyo okanye esebenzayo ekunyangeni i-BBB njengokutya kwe-ketogenic eyenziwe kakuhle. Akukho nanye kwezi ephilisayo ukumelana ne-insulin. Akukho nanye kwezi enye imithombo yamafutha engqondo. Ezinye zezi zinto zinokuphucula umsebenzi kunye nokuhamba kwegazi kwiiseli ze-epithelial kunye ne-endothelial, kwaye ezinye zinokubonelela ngesenzo esiphuculweyo se-antioxidant ukuze uzame ukudlala ukubamba kunye noxinzelelo lwe-oxidative.
Ngaba uya kufumana ukuphiliswa kwe-BBB kwezi zongezo? Ewe, unako. Logama nje i-neurodeergenerative cascade uqhubeka ayinawo amandla amaninzi. Kodwa ukuba ukufikeleleka kwakho kwe-BBB kubangelwa sistrowuku okanye i-TBI, okanye iinkqubo ze-dementia kwangethuba, ezi aziboneleli ngomthombo wamafutha ochanekileyo ofunekayo ingqondo yakho ukulwa ne-hypometabolism yobuchopho. Ezi zongezelelo aziboneleli nge-micronutrients ephuculweyo okanye i-macronutrients yokugcina kunye nokulungiswa kubuchopho obuphuculweyo kunye nokusebenza kwe-BBB.
Ukuba uzimisele ngokuphilisa ingqondo yakho, ungoyiki ukwenza le nto uyicingayo inzima kakhulu. Ndiyakuthembisa, ukuba ukufunda indlela yokuphumeza kunye nokugcina ukutya kwe-ketogenic akunzima kangako njengokuba nengqondo engasebenzi. Ingqondo ekugcina ukuba ukonwabele ubomi ngokupheleleyo.
Ingqondo ehlala icinezelekile ngemiba yeemvakalelo kunye neengxaki zememori?
OKO KUNZIMA. Yonke. Ungatshatanga. Usuku.
Ukutya okune-ketogenic kuyindlela yokufunda kwaye ufanelwe inkxaso ekuyiphumezeni. Kodwa ndiyakuthembisa, njengomntu obuyise ingqondo yam, ayiphantse yanzima njengoko ucinga. Sele uhamba kwenye yezona zinto zinzima. Ukutya kwe-Ketogenic kulula xa kuthelekiswa.
Izongezo ezinokuncedisa ukulungiswa kwe-BBB ziquka ioli yeentlanzi, i-Ginko Bilboa, i-vinpocetine, i-alpha-lipoic acid, i-glutathione (fumana i-liposomal okanye i-precursors ebalulekileyo, funda ukuba kutheni Apha), kunye ne-resveratrol.
Ngamanye amaxesha ndiya kusebenzisa ezinye zezi ukongeza kwi-ketogenic yokutya njengonyango lokuncedisa, kodwa andizisebenzisi ngokwazo ukuphilisa iiBBB okanye ezinye iindawo zengqondo. Kwaye ke, andiwazi ngokuthe ngqo iidosi ezisetyenziswa ngabantu ukuba bazisebenzisa njengonyango olusisiseko ngale njongo. Kodwa kwakhona, uya kuba nakho ukuphanda ezo ziguquguqukayo zokuphiliswa kwakho.
isiphelo
KwiNkqubo yokuBuyiselwa kweNkungu yoBuchule endiyifundisayo, sisebenzisa ukutya kwe-ketogenic, ukongezwa kwesondlo sobuqu, kunye noqeqesho olubhekiselele kungenelelo lwamayeza asebenzayo anceda ukunyanga i-BBB evuzayo kwaye incede abantu baphile ubomi babo obugqwesileyo. Kaloku masinyaniseke. Ubabona njani ubomi? Ngengqondo yakho. Akunyanzelekanga ukuba uphile kunye neempawu zenkungu yengqondo, kungakhathaliseki isizathu okanye ukuxilongwa. Kungenxa yokuba ugqirha wakho akazihoyi izikhalazo zakho malunga nokungakwazi ukugxila, ukukhumbula izinto, okanye ukugcina isimo sakho sengqondo akuthethi ukuba akukho unyango olusebenzayo.
Ndiyavuya ukukunceda ufunde zonke iindlela onokuziva ngcono ngazo!
Ucaphulo
Achanta, LB, & Rae, CD (2017). I-β-Hydroxybutyrate kwiBrain: I-Molekyuli enye, iiMechanism ezininzi. Uphando lwe-Neurochemical, 42(1), 35-49. https://doi.org/10.1007/s11064-016-2099-2
Carnevale, R., Pastori, D., Nocella, C., Cammisotto, V., Baratta, F., Del Ben, M., Angelico, F., Sciarretta, S., Bartimoccia, S., Novo, M. , Targher, G., & Violi, F. (2017). I-endotoxemia ye-low-grade, i-gut permeability kunye ne-platelet activation kwizigulane ezinokuphazamiseka kokuzila ukutya kwe-glucose. Isondlo, i-Metabolism kunye neZifo ze-Cardiovascular, 27(10), 890-895. https://doi.org/10.1016/j.numecd.2017.06.007
Cheng, S., Chen, G.-Q., Leski, M., Zou, B., Wang, Y., & Wu, Q. (2006). Umphumo we-d, l-β-hydroxybutyric acid kwi-cell death kunye nokwanda kweeseli ze-L929. Izinto eziphilayo, 27(20), 3758-3765. https://doi.org/10.1016/j.biomaterials.2006.02.046
Chiry, O., Fishbein, WN, Merezhinskaya, N., Clarke, S., Galuske, R., Magistretti, PJ, & Pellerin, L. (2008). Ukuhanjiswa kwe-monocarboxylate transporter MCT2 kwi-cortex ye-cerebral yomntu: isifundo se-immunohistochemical. Uphando lobuchopho, 1226, 61-69. https://doi.org/10.1016/j.brainres.2008.06.025
Chiry, O., Pellerin, L., Monnet-Tschudi, F., Fishbein, WN, Merezhinskaya, N., Magistretti, PJ, & Clarke, S. (2006). Ukubonakaliswa kwe-monocarboxylate transporter MCT1 kwi-cortex yobuchopho bomntu omdala. Uphando lobuchopho, 1070(1), 65-70. https://doi.org/10.1016/j.brainres.2005.11.064
Choquet, D., & Triller, A. (2013). I-Dynamic Synapse. Neuron, 80(3), 691-703. https://doi.org/10.1016/j.neuron.2013.10.013
Cucullo, L., Hossain, M., Puvenna, V., Marchi, N., & Janigro, D. (2011). Indima yoxinzelelo lwe-chear kwi-Blood-Brain Barrier endothelial physiology. I-BMC Neuroscience, 12(1), 40. https://doi.org/10.1186/1471-2202-12-40
Cummins, PM (2011). Occludin: Iprotheyini enye. Iifom ezininzi. Mol. Iseli. I-Biol. 32, 242–250. doi: 10.1128/mcb.06029-11
UDamir Janigro. (nd). IJMS | Isiqendu Esigcweleyo sasimahla | Imizimba yeKetone iKhuthaza i-Amyloid-β1-40 ukuCoca kuMntu kwi-Vitro Blood-Brain Barrier Model. Ibuyisiwe ngoJuni 5, 2022, ukusuka https://www.mdpi.com/1422-0067/21/3/934
UDamir Janigro. (2022). Iimpembelelo ze-Ketogenic Diet kwi-Blood-Brain Barrier. Kwi Ukutya kwe-Ketogenic kunye noNyango lweMetabolic: Iindima ezongeziweyo kwiMpilo kunye neZifo (uhlelo lwe-2, iphepha 346-363). Oxford University Press.
Datis Kharrazian. (2020, Julayi 23). Ubuchopho obuvuzayo: Inkungu yengqondo, ukulahleka kwenkumbulo, ukudakumba. https://www.youtube.com/watch?v=ulj5wuGajFw
Fasano, A. (2020). Sonke isifo siqala kwi-gut (evuzayo): Indima ye-zonulin-mediated gut permeability kwi-pathogenesis yezinye izifo ezingapheliyo ezivuthayo. F1000 Uphando, 9, F1000 Faculty Rev-69. https://doi.org/10.12688/f1000research.20510.1
FoundMyFitness. (2022, Meyi 31). Ukuqina kwamathumbu: Ikhonkco lebhaktheriya ekwaluphaleni, ukungasebenzi kakuhle kweBrain Barrier kunye neMetabolic Disorder. https://www.youtube.com/watch?v=evQAzGaW1JU
Imida | Iimpawu zeNeurological ze-COVID-19: I-Zonulin Hypothesis | I-Immunology. (nd). Ifunyenwe ngoMeyi 22, 2022, ukusuka https://www.frontiersin.org/articles/10.3389/fimmu.2021.665300/full
Gibson, CL, Murphy, AN, & Murphy, SP (2012). Isiphumo se-stroke kwimeko ye-ketogenic - ukuphononongwa ngokuchanekileyo kwedatha yezilwanyana. Journal of Neurochemistry, 123(s2), 52-57. https://doi.org/10.1111/j.1471-4159.2012.07943.x
Iprotheyini ye-Glial Fibrillary Acidic—Ushwankathelo | Izihloko zeSayensiDirect. (nd). Ifunyenwe ngoMeyi 22, 2022, ukusuka https://www.sciencedirect.com/topics/neuroscience/glial-fibrillary-acidic-protein
Jensen, NJ, Wodschow, HZ, Nilsson, M., & Rungby, J. (2020). Iimpembelelo ze-Ketone Bodies kwi-Brain Metabolism kunye noMsebenzi kwi-Neurodeergenerative Diseases. I-International Journal ye-Molecular Sciences, 21(22), 8767. https://doi.org/10.3390/ijms21228767
Kadry, H., Noorani, B., Bickel, U., Abbruscato, TJ, & Cucullo, L. (2021). Uvavanyo oluthelekisayo lwe-in vitro BBB tight junction imfezeko emva kokuvezwa kumsi wecuba kunye nomphunga we-e-cigarette: Uvavanyo lobungakanani beziphumo ezikhuselayo ze-metformin zisebenzisa iimpawu ezincinci ze-molecular-weight paracellular markers. Ulwelo kunye nezithintelo ze-CNS, 18(1), 28. https://doi.org/10.1186/s12987-021-00261-4
Kakaroubas, N., Brennan, S., Keon, M., & Saksena, NK (2019). I-Pathomechanism yokuphazamiseka kwe-Blood-Brain Barrier kwi-ALS. Ijenali yeNeuroscience, 2019, e2537698. https://doi.org/10.1155/2019/2537698
Llorens, S., Nava, E., Muñoz-López, M., Sánchez-Larsen, Á., & Segura, T. (2021). Iimpawu zeNeurological ze-COVID-19: I-Zonulin Hypothesis. Imida e-Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.665300
UMasino, SA (2022). Ukutya kwe-Ketogenic kunye noNyango lweMetabolic: Iindima ezongeziweyo kwiMpilo kunye neZifo. IYunivesithi yaseOxford Press.
UMasino, SA, & Rho, JM (2012). Iinkqubo ze-Ketogenic Diet Action. Kwi-JL Noebels, M. Avoli, MA Rogawski, RW Olsen, & AV Delgado-Escueta (Eds.), IiNdlela eziSisiseko zikaJasper zeZithuthwane (uhlelo lwesi-4). Iziko leSizwe loLwazi lweBiotechnology (US). http://www.ncbi.nlm.nih.gov/books/NBK98219/
UMorris, G., Fernandes, BS, Puri, BK, Walker, AJ, Carvalho, AF, & Berk, M. (2018). Ingqondo evuzayo kwi-neurological and psychiatric disorders: Abaqhubi kunye neziphumo. I-Australia kunye neNew Zealand Journal of Psychiatry, 52(10), 924-948. https://doi.org/10.1177/0004867418796955
Olung, NF, Aluko, OM, Jeje, SO, Adeagbo, AS, & Ijomone, OM (2021). Ukungasebenzi kakuhle kweVascular kwiBrain; Iimpembelelo kwi-Heavy Metal Exposures. Uphononongo lwangoku loxinzelelo lwegazi, 17(1), 5-13. https://doi.org/10.2174/1573402117666210225085528
Rahman, MT, Ghosh, C., Hossain, M., Linfield, D., Rezaee, F., Janigro, D., Marchi, N., & van Boxel-Dezaire, AHH (2018). I-IFN-γ, i-IL-17A, okanye i-zonulin inyusa ngokukhawuleza ukunyanzeliswa kwegazi-ingqondo kunye nezithintelo ze-epithelial zamathumbu amancinci: Ukufaneleka kwezifo ze-neuro-inflammatory. UkuNxibelelana koPhando lwezinto zeMvelo kunye noBuchule, 507(1), 274-279. https://doi.org/10.1016/j.bbrc.2018.11.021
Iingxelo | Isiqendu Esigcweleyo sasimahla | I-Gluten Ataxia eNxulunyaniswe ne-Dietary Protein Cross-Reactivity kunye ne-GAD-65. (nd). Ifunyenwe ngoMeyi 22, 2022, ukusuka https://www.mdpi.com/2571-841X/3/3/24
I-Rhea, i-EM, kunye neeBhanki, i-WA (2019). Indima yeGazi-Brain Barrier kwiCentral Nervous System Resistance Insulin. Imida kwi-Neuroscience, 13. https://www.frontiersin.org/article/10.3389/fnins.2019.00521
URose, J., Brian, C., Pappa, A., Panayiotidis, MI, & Franco, R. (2020). I-Mitochondrial Metabolism kwi-Astrocytes ilawula i-Brain Bioenergetics, i-Neurotransmission kunye ne-Redox Balance. Imida kwi-Neuroscience, 14. https://www.frontiersin.org/article/10.3389/fnins.2020.536682
Takahashi, S. (2020). I-Metabolic compartmentalization phakathi kwe-astroglia kunye ne-neurons kwiimeko ze-physiological kunye ne-pathophysiological yeyunithi ye-neurovascular. I-Neuropathology, 40(2), 121-137. https://doi.org/10.1111/neup.12639
Vojdani, A., Vojdani, E., & Kharrazian, D. (2017). Ukuguquguquka kwamanqanaba e-zonulin egazini vs ukuzinza kwee-antibodies. Ijenali yehlabathi ye-Gastroenterology, 23(31), 5669-5679. https://doi.org/10.3748/wjg.v23.i31.5669
U-Xiao M, u-Xiao ZJ, u-Yang B, u-Lan Z kunye no-Fang F (2020) Isithintelo se-Blood-Brain: Igalelo elingakumbi ekuPhazamiseni kwe-Homeostasis ye-Nervous System ePhambili kuneXhoba kwi-Neurological Disorders. Umphambili. Neurosci. I-14: 764. i-doi: 10.3389 / fnins.2020.00764
Xylaki, M., Atzler, B., & Outeiro, TF (2019). I-Epigenetics ye-Synapse kwi-Neurodegeneration. I-Neurology yangoku kunye neeNgxelo zeNeuroscience, 19(10), 72. https://doi.org/10.1007/s11910-019-0995-y
Yang, Z., & Wang, KKW (2015). Iprotheni ye-Glial Fibrillary acidic: Ukusuka kwindibano ye-filament ephakathi kunye ne-gliosis ukuya kwi-neurobiomarker. Iindlela ezibonakalayo kwi-Neurosciences, 38(6), 364-374. https://doi.org/10.1016/j.tins.2015.04.003
Zekeridou, A., & Lennon, VA (2015). I-Aquaporin-4 autoimmunity. I-Neurology-Neuroimmunology Neuroinflammation, 2(4). https://doi.org/10.1212/NXI.0000000000000110
UZheng, W., & Ghersi-Egea, J.-F. (2020). I-ToxPoint: IiNkqubo zoMqobo woBuchule azidlali iindima ezincinci kwi-Toxicant-induced Brain Disorders. IiSayensi zeTyhefu, 175(2), 147-148. https://doi.org/10.1093/toxsci/kfaa053
2 Comments