Ukutya kwe-Ketogenic: I-Molecular Signaling Therapy enamandla kwiBrain
Ixesha lokufunda eliqikelelweyo: 6 imizuzu
Awukwazi ukuyiqonda, kodwa i-ketone body BHB, eveliswa xa ilandela ukutya kwe-ketogenic, i-agent ye-molecular signaling agent. Kule post blog siza kujonga kwimiphumo yeBHB kwi-neurons yakho kunye neendlela zofuzo ezichaphazelekayo. Ke, masingene kwihlabathi elinomdla lokubonakaliswa komzimba we-ketone. 🌊
Abaphandi basanda kuhlola iziphumo ze-BHB kwi-basal autophagy, mitophagy, kunye ne-mitochondrial kunye ne-lysosomal biogenesis kwi-cortical cultured neurons enempilo. Kubalulekile ukuqaphela ukuba olu phononongo lwenziwe kwi-petri dish, hayi kwizinto eziphilayo. Nangona kunjalo, iziphumo ziyamangalisa ngokwenene.
Iziphumo zibonisa ukuba i-D-BHB yandisa amandla e-membrane ye-mitochondrial kwaye ilawula i-NAD+/Umlinganiselo weNADH. I-D-BHB iphuculwe i-FOXO1, i-FOXO3a kunye ne-PGC1α amanqanaba enyukliya ngendlela exhomekeke kwi-SIRT2 kunye ne-autophagy, i-mitophagy kunye ne-mitochondrial biogenesis.
Gómora-García, JC, Montiel, T., Hüttenrauch, M., Salcido-Gómez, A., García-Velázquez, L., Ramiro-Cortés, Y., ... & Massieu, L. (2023). Umphumo we-Ketone Body, i-D-β-Hydroxybutyrate, kwi-Sirtuin2-Mediated Regulation yoLawulo lweMitochondrial Quality kunye ne-Autophagy-Lysosomal Pathway. Iiseli, 12(3), 486. https://doi.org/10.3390/cells12030486
Unokufunda ngakumbi malunga nale mitochondrial ibalulekileyo imisebenzi kule post blog ndabhala.
Okokuqala, makhe ndicacise ukuba olu pho nonongo lwalusebenzisa i-D-BHB. I-DBHB yi-ketone efana ne-bio kwi-ketone eyenziwa ngumzimba wakho xa iphula amanqatha kwi-ketone. Ukuba ufuna ukufunda ngakumbi nge-D-BHB unokufuna ukufunda eli nqaku leblogi endilibhalileyo kweso sihloko!
Masibuyele kwinto abayifumeneyo!
Iziphumo zibonise ukuba ukubonakaliswa kwe-D-BHB kuphucula umsebenzi we-mitochondrial kwaye ivuselela i-autophagy, i-mitophagy kunye ne-mitochondrial biogenesis ngokunyanzeliswa kwezinto ezibhaliweyo kwiintlobo ezahlukeneyo zofuzo.
Ukulawulwa kwezinto ezibhaliweyo kuthetha ukuba isixa okanye umsebenzi weeprotheyini ezithile zonyuswa, ezinokunyusa ukubonakaliswa kweejene ezilawulayo.
Ngawaphi amajini abone i-D-BHB inesiphumo?
I-FOX01 kunye ne-FOX03a
I-FOXO1 kunye ne-FOXO3a zizinto ezibhaliweyo ezidlala indima ebalulekileyo kwiinkqubo ezininzi zeselula, kuquka ukuhlukana kweeseli, i-metabolism, kunye nokuphendula uxinzelelo. Bafumene i-D-BHB i-exposure exposure iphakamisa intetho ye-FOXO1 kunye ne-FOXO3a. Ezi ziindlela ezikhuthaza ukubonakaliswa kwezakhi zofuzo ezibandakanyekayo kwi-mitochondrial kunye ne-lysosomal biogenesis. Kutheni oku kubalulekile?
Ngenxa yokuba ukulawulwa kwe-FOXO1 kunye ne-FOXO3a nge-D-BHB kwandisa amandla e-neurons ukuphucula amandla e-metabolism, ukunciphisa uxinzelelo lwe-oxidative, kunye nokuphucula ukuchithwa kwenkunkuma yamaselula.
I-FOXO1 kunye ne-FOXO3a ziyaziwa ukuba zisebenze kwaye zikhuthaze ukubonakaliswa kwezakhi zofuzo ezibandakanyekayo kwi-biogenesis ye-mitochondrial, njenge-PGC-1α, i-NRF1, kunye ne-TFAM.
I-PGC-1α, i-NRF1, kunye ne-TFAM zonke ziyimfuza ezifakela iiprotheni zegama elifanayo. Xa ezi zakhi zofuzo zibonakaliswa, iiprotheni ezibangelwayo (PGC-1α, NRF1, kunye neTFAM) zisebenza kunye ukukhuthaza iqela le-molecular signaling goodness endifuna ukukuxelela ngayo!
PGC-1α
I-PGC-1α, okanye i-peroxisome proliferator-activated receptor gamma coactivator 1-alpha, iprotheni edlala indima ebalulekileyo ekudaleni nasekugcineni i-mitochondria enempilo kwi-neurons. Ifezekisa oku ngokukhuthaza ukuveliswa kwe-mitochondria entsha kunye nokuphucula amandla e-mitochondria ekhoyo ukuvelisa amandla.
I-PGC-1α ikhuthaza ukuveliswa kwe-mitochondria entsha kwi-neurons ngokuvula izakhi zofuzo ezibandakanyekayo kwi-biogenesis ye-mitochondrial, inkqubo eyenziwa ngayo i-mitochondria entsha. Le nkqubo ibalulekile ekuqinisekiseni ukuba ii-neuron zinemitochondria eyaneleyo yokuxhasa iimfuno zabo zamandla aphezulu. Ukongezelela, i-PGC-1α iphucula amandla e-mitochondria ekhoyo ukuvelisa amandla ngokuguqula izakhi zofuzo ezibandakanyekayo kwi-phosphorylation ye-oxidative, inkqubo eyenziwa yi-ATP.
Ngaphezu koko, i-PGC-1α iyaziwa ngokulawula ukuveliswa kwe-antioxidant enzymes ekhusela i-mitochondria kuxinzelelo lwe-oxidative. Uxinzelelo lwe-oxidative luhlobo loxinzelelo olungonakalisa i-mitochondria kunye namanye amacandelo eselula kwaye kunokukhokelela kukungasebenzi kwe-neuronal kunye nokufa kweeseli.
I-D-BHB, umzimba we-ketone oveliswa yi-biologically eyenziwa ngabantu kwi-ketogenic diet, inceda i-PGC-1α isebenze ngcono ukwenza i-mitochondria eninzi kwaye inceda loo mitochondria isebenze ngcono. Kwaye ngokungathi oko akwanelanga, ikunceda wenze i-antioxidants oyifunayo ukunciphisa uxinzelelo lwe-oxidative.
NRF1
I-NRF1, okanye i-nuclear factor 1, yinto ebhaliweyo edlala indima ebalulekileyo ekudaleni nasekugcinweni kwe-mitochondria enempilo. Isebenza ngokuvula iijini ezivelisa iiproteni ezifunekayo ekusebenzeni kwe-mitochondrial. Le nkqubo ibalulekile ekuqinisekiseni ukuba i-mitochondria inokuvelisa amandla ngokufanelekileyo.
I-Mitochondria yi-organelles eyinkimbinkimbi efuna iindidi zeeprotheni ukuze zisebenze ngokufanelekileyo. Ezinye zezi proteni ziveliswa kwinucleus yeseli emva koko zithuthelwe kwimitochondria. I-NRF1 inceda ukulungelelanisa le nkqubo ngokuvula iijini ezivelisa ezi proteni. Ezi proteni ziquka ezifunekayo kwimveliso yamandla kunye nababandakanyekayo ekugcinweni kwesakhiwo se-mitochondrial kunye nokulawulwa kokuphindaphinda kwe-mtDNA.
I-NRF1 ibaluleke kakhulu kumsebenzi we-mitochondrial kuba ilawula ukubonakaliswa kwezakhi zofuzo ezibandakanyekayo kwi-phosphorylation ye-oxidative, inkqubo efunekayo ekuveliseni i-ATP, imali engundoqo yamandla yeseli. Ikwabandakanyeka ekulawuleni i-biogenesis ye-mitochondrial, inkqubo eyenziwa ngayo i-mitochondria entsha.
Ukongeza kwindima yayo kumsebenzi we-mitochondrial, i-NRF1 iye yabandakanyeka kulawulo lweempendulo zoxinzelelo lweselula. Ibandakanyeka ekusebenziseni iijene ezikhusela iiseli kuxinzelelo lwe-oxidative, uhlobo loxinzelelo olungonakalisa i-mitochondria kunye nezinye iiseli zeselula.
I-D-BHB, umzimba we-ketone oveliswa yi-biologically owenziwe ngabantu kwi-ketogenic diet, inceda i-NRF1 isebenze ngcono ukwenza i-mitochondria eninzi, ukulawula ukuveliswa kwamandla kunye nokunceda ukukhusela ingqondo yakho kwixinzelelo lwe-oxidative.
I-TFAM
I-TFAM, emele i-mitochondrial transcription factor A, yiprotheni edlala indima ebalulekileyo ekudaleni nasekugcineni imitochondria enempilo. Ikwenza oku ngokukhuthaza ukuphindaphindwa kwe-mtDNA. I-TFAM ibophelela kwi-mtDNA kwaye isebenze njengoluhlobo "lwe-master regulator" yokuphindaphinda kwe-mtDNA. Xa i-TFAM ikhona, ixela iseli ukuba yenze iikopi ezininzi ze-mtDNA.
Ukuphindaphindwa kwe-mtDNA kubalulekile ekudalweni kwe-mitochondria entsha. Njengoko iiseli zikhula kwaye zihlukana, kufuneka zenze i-mitochondria entsha ukuxhasa iimfuno zabo zamandla ezongeziweyo. Ukuba ukuphindaphinda kwe-mtDNA akwenzeki ngokufanelekileyo, iseli ayinakukwazi ukwenza i-mitochondria entsha eyaneleyo, ekhokelela ekunciphiseni ukuveliswa kwamandla kunye nemiphumo enokuba yingozi kwiseli.
I-D-BHB, umzimba we-ketone oveliswa yi-biologically eyenziwa ngabantu kwi-ketogenic diet, inceda i-TFAM ukuqinisekisa ukuba i-mitochondria entsha inokudalwa.
isiphelo
Ngoko ke ndifuna ukucaca malunga nokuba kuthetha ukuthini oku. Oku kuthetha ukuba ukutya kwe-ketogenic luphawu olunamandla lwemfuza, unyango lwe-metabolic yengqondo.
Olu luphawu olunamandla ngakumbi lwemolekyuli kunokuba uya kuze ufumane ngamaqunube kunye nesalmon. Ndiyazi njani le nto?
Ngenxa yokuba abantu abaninzi baye bahamba indlela ye-blueberry kunye ne-salmon kwaye abazange bafumane ukuhlangulwa kweemvakalelo kunye nokusebenza kwengqondo kufutshane nenqanaba abahlangabezana nalo ngokutya kwe-ketogenic.
Mhlawumbi sele uzame indlela yeblueberry kunye nesalmon, okanye awuzukuba lundwendwe kwibhlog yam. Ndifuna ukuba wazi ukuba ayilotyala lakho ukuba iiblueberries kunye nesalmon azenzanga ngokwaneleyo.
Awukafumani zonke iindlela onokuziva ngcono ngazo.
Ucaphulo
Cuenoud, B., Hartweg, M., Godin, JP, Croteau, E., Maltais, M., Castellano, CA, ... & Cunnane, SC (2020). I-Metabolism ye-D-beta-hydroxybutyrate yangaphandle, i-substrate yamandla esetyenziswa ngamandla yintliziyo kunye nezintso. Imida kwiZondlo, 13. https://pubmed.ncbi.nlm.nih.gov/32140471/
Gómora-García, JC, Montiel, T., Hüttenrauch, M., Salcido-Gómez, A., García-Velázquez, L., Ramiro-Cortés, Y., ... & Massieu, L. (2023). Umphumo we-Ketone Body, i-D-β-Hydroxybutyrate, kwi-Sirtuin2-Mediated Regulation yoLawulo lweMitochondrial Quality kunye ne-Autophagy-Lysosomal Pathway. Iiseli, 12(3), 486. https://doi.org/10.3390/cells12030486
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