Ngaba izongezo ze-BHB zangaphandle ziyakunyanga ukugula kwam ngengqondo?
Ndiyayifumana. Awufuni ukutshintsha ukutya kwakho. Iyaqondakala ngokupheleleyo. Kwaye impendulo yam ukuba exogenous β-I-Hydroxybutyrate (eyaziwa ngokuba yi-beta hydroxy-butyrate okanye i-BHB) izongezelelo ziya kunyanga isifo sakho sengqondo kukuba andiyazi. Kwaye neengcali kwii-exogenous ketones aziyazi. Nangona beqikelele ngamandla ukuba kunokubakho inzuzo entle,
... kunokwenzeka ukuba i-ketone eyongezelelweyo-eyenziwe i-ketosis ingaba sisixhobo esisebenzayo sonyango ngokuchasene nezifo zengqondo. Enyanisweni, izongezo ze-ketone zangaphandle zinempembelelo yokulinganisa ekuziphatheni kunye nefuthe le-anxiolytic kwizifundo zezilwanyana.
Kovács, Z., D'Agostino, DP, Diamond, D., Kindy, MS, Rogers, C., & Ari, C. (2019). Ikhono lonyango lwe-exogenous ketone supplement induced ketosis kunyango lweengxaki zengqondo: ukuphononongwa koncwadi lwangoku. Imida kunyango lwengqondo, 363. https://doi.org/10.3389/fpsyt.2019.00363
Imeko yangoku yoPhando kwi-BHB Supplementation
Kodwa xa olo hlaziyo lubhalwa kwi-2019 uphando aluzange lwenziwe ukuphendula umbuzo wokuba ukuxhaswa kweBHB kunokuphatha isifo sengqondo. Kwaye ngeli xesha ndibhala eli nqaku leblogi ufundayo, asikayazi impendulo. Uphando alwenziwanga ngokwaneleyo ukuphendula umbuzo wokuba ingaba i-BHB supplementation yodwa iya kunyanga isifo sakho sengqondo.
Okwangoku, kukho ukungabikho kophando olubanzi malunga nokuxhaswa kweBHB njengonyango oluzimeleyo lwezifo zengqondo. Okwangoku, izifundo zecala ezipapashwe, iimvavanyo zokulinga, kunye neZilingo eziLawulwayo eziLawulwayo (RCTs) zijolise ngokukodwa ekusebenzeni kokutya kwe-ketogenic ekuphatheni iimeko zempilo yengqondo. Ndiya kucinga ukuba kwixesha elizayo, uphando luya kwandisa ukuphanda ukuxhaswa kweBHB kwizifo zengqondo ezahlukeneyo. Ndingalindela (kwaye ndinethemba) ukubona izifundo ezithelekisa iziphumo zezigulane kwizidlo ze-ketogenic kulabo basebenzisa izongezo ze-BHB kuphela. Ukongezelela, uphando lunokuphonononga iziphumo ezidibeneyo zokutya kwe-ketogenic kunye neetyuwa ze-ketone ezongezelelweyo okanye ezinye iindlela ze-BHB.
Ukutya kwe-Ketogenic kunye nobudlelwane babo kwiBHB
Makhe sijonge olophononongo lupholileyo lophando olwenziweyo kungekudala, sijonge kwi Amandla oNyango lwe-Exogenous Ketone Supplement eyenziwe yi-Ketosis kuNyango lweZiphazamiso zengqondo.. Baye bakhupha into eninzi kuphando malunga nokutya kwe-ketogenic. Ngoba? Ngenxa yokuba ukutya kwe-ketogenic kuvelisa imizimba emithathu ye-ketone, enye yazo yiBHB.
Kodwa akukho ndawo ekuphononongweni kwabo bacebisa ukuba uzame ukusebenzisa ukuxhaswa kwe-BHB yangaphandle njengonyango lwesifo sakho sengqondo. Baxubusha iindlela ezisisiseko apho iBHB, njengomzimba we-ketone, inceda ukunyanga izifo ze-neurological kunye nesifo sengqondo, esingenakuchukumisa kwaye sinethemba. Ababhali bahlonishwa kakhulu ngabaphandi bemizimba ye-ketone kwaye banamava eklinikhi ngokusebenzisa ii-ketones zangaphandle ezineemeko ezahlukeneyo ze-neurological. Kwaye naba babhali babiza ukuqhubela phambili kwezifundo ezijonge ukusetyenziswa kwe-BHB eyongezelelweyo yangaphandle kubantu bengqondo.
Ngoba? Ngenxa yokuba uphando lwangoku luxhasa kakhulu ukusetyenziswa kwezidlo ze-ketogenic zokuphazamiseka kwe-neurological kunye nezifo zengqondo ezahlukeneyo. Ubuncinci ngeli xesha.
Kutheni uphando olongezelelweyo lubalulekile
Kodwa oko akuyi kuba sisiphelo sengxoxo yethu. Kuba ndingumntu onomdla ngokwam, ndiwuqhwabela izandla umbuzo wakho ocingisiswe kakuhle nonengqiqo. Ngokwenene ngumbuzo olungileyo ngenene. Kwaye ndifuna ukuba wazi ukuba ezi zinto zikwacingelwa ngabaphandi.
Umzekelo, kukho ngokwenene isithembiso sophando esinomdla kunye nezicelo zeklinikhi ze-BHB zokungeniswa njengonyango kwiimeko zokhathalelo olunzima.
Njengoko i-BHB inokusebenza njengenye i-substrate ye-metabolic kwi-glucose ngexesha loxinzelelo olunamandla, kukho umdla okhulayo wokusetyenziswa kwe-IV BHB kwiimeko ezinzima, ezigulayo ezifana nokulimala kwengqondo, okanye ukulimala kwe-ischemic kwingqondo okanye intliziyo.
Storoschuk, KL, Wood, TR, & Stubbs, BJ (2023). Uphononongo olucwangcisiweyo kunye ne-meta-regression of exogenous ketone infusion rates kunye nesiphumo se-ketosis-Isixhobo seekliniki kunye nabaphandi. Imida kwiPhysics, 14. https://doi.org/10.3389/fphys.2023.1202186
Yintoni ebambe oku njengokhetho kwiiyunithi zokhathalelo olubalulekileyo? Kuyabonakala ukuba, ayikabikho iBHB efumanekayo kwezorhwebo kule fomu okwangoku. Umntu kufuneka enze loo nto!
... indima ye-ketosis yonyango kwiimeko ezinzima ze-pathological ezifana nokwenzakala kwengqondo, ukubetha, ukungaphumeleli kwentliziyo kunye nezinye izifo ziye zaphandwa kakhulu ngenxa yokungabikho kobonelelo olufumanekayo lwezorhwebo lwe-BHB emithanjeni.
White, H., Heffernan, AJ, Worrall, S., Grunsfeld, A., & Thomas, M. (2021). Ukuphononongwa okuCwangcisiweyo kwe-Intravenous β-Hydroxybutyrate Ukusetyenziswa kuBantu-Unyango oluthembisayo lwexesha elizayo?. Imida kwezamayeza, 1611. https://doi.org/10.3389/fmed.2021.740374
Ukuba bekukho i-IV BHB efumaneka ngokulula, ndicinga ukuba kuya kuhlala ixesha elide ngaphambi kokuba siyibone njengenxalenye yonyango lwengqondo. Nangona ndivuma ukuba kuya kuba nomdla ngokwenene ukubona izifundo zophando ziyilwe ngononophelo ukusetyenziswa kwayo kwiimeko ezibukhali zengqondo apho imvume yonyango isenokunikezelwa, kwaye imvume ye-IRB yophononongo lukhetho.
Kodwa akukho mfuneko yokulinda iindlela ze-IV zokuhanjiswa! Ufanele ukwazi ukuba ukuxhaswa kwe-BHB yangaphandle kunokuza kuzo zonke iintlobo zeefom kodwa ngokuqhelekileyo zenziwe ngokudibanisa i-BHB kunye neetyuwa zamaminerali (oko kukuthi, i-potassium, i-calcium, i-sodium, okanye i-magnesium). Imixube (i-racemic) yeefom ze-D kunye ne-L-BHB, i-D-BHB yodwa, kunye nezinye ezingabotshwanga kwiiminerali (iityuwa) ziyafumaneka.
Kukho i-ketone esters eneempawu zabo zomntu ngamnye kunye nokuqwalaselwa. Abanye baneendlela zombini ze-D kunye ne-L ze-BHB, ezinye ziyi-monoesters kwaye zibonelela nge-D-BHB kuphela. Kukho uqwalaselo olusebenzayo olufana neendleko kunye nezinye iindlela ezingcamla kakubi kakhulu, kodwa nangokubhekiselele kwiziphumo zazo kwimetabolism. Zonke zizinto ezifuna ukuvavanywa ngabantu bempilo yengqondo abajonge ukuzisebenzisa njengenxalenye yokutya kwe-ketogenic okanye njengonyango oluzimeleyo lweempawu zempilo yengqondo. Zonke ezi zintlukwano ziya kuzuza kufundo.
Ukuxhaswa kweBHB Yedwa: Umbono weKlinikhi
Ndime phi kwi-BHB supplementation ndedwa?
Ndiqhubeka ndivuya kakhulu malunga nophando olusakhulayo lwe-Beta-Hydroxybutyrate (BHB) kunye nendima yalo kwimpilo ye-neuropsychiatric. Kuyathembisa kakhulu. Nangona kunjalo ndifuna ukucaca ngokwenene ngombono wam wangoku malunga nokusetyenziswa kweBHB njengonyango oluzimeleyo lwezifo zengqondo kunye nokuphazamiseka kwengqondo. Njengoko uphando luphuma, uluvo lwam lunokutshintsha ngokupheleleyo. Njengamaxesha onke, ndinelungelo lokutshintsha uluvo lwam ngokusekelwe kwinto endiyifundayo kwixesha elizayo kunye nophando olukhulu oluya kuphuma ngokuqinisekileyo.
Kodwa nantsi into. Andikholelwa ukuba ukongeza nje nge-BHB okanye i-ketone salts kuya kusebenza njengonyango olusebenzayo lwesifo sengqondo. Kwinkqubo yam yeklinikhi, ngamanye amaxesha ndibona ukuphuculwa kwengqondo kunye nokusebenza kwengqondo usebenzisa i-Ketone Salts (BHB Salts) njengesincedisi phezu kokutya kwe-ketogenic eyenziwe kakuhle leyo ilungiselelwe unyango lwesifo sengqondo kunye nomsebenzi we-neurological. Ndibe nabantu abaninzi bazama nje ukongezwa kweetyuwa zeBHB kuphela, ngaphandle kokutshintsha ukutya kwabo.
Ngelixa kukho umntu ofumana ukuphucuka okubalulekileyo ngokwaneleyo kwaye ayeke apho, andizange ndiyibone imeko yezigulo zengqondo ezimandundu, ezifana ne-schizophrenia, i-bipolar, ukudakumba okunganyangekiyo kunyango, okanye ukuxhalaba okungapheliyo. Uninzi, naluphi na uphuculo olubonwa ekunciphiseni iimpawu luchazwa njengolunganelanga okanye oludlulayo. Makhe sithethe ngesizathu sokuba kube njalo.
Izigulo zengqondo ziimeko ezintsonkothileyo eziphenjelelwa zizinto ezininzi, kubandakanya imfuza, indawo esingqongileyo, indlela yokuphila, kunye nekhemikhali yobuchopho, zonke ezichatshazelwa kakhulu yimpilo yemetabolism. Izibonelelo zeBHB kumxholo wokutya kwe-ketogenic ziyinxalenye yokutshintshwa kwe-metabolic ebanzi ngaphakathi komzimba kunye nengqondo, ukutshintshwa okungachazwanga ngokupheleleyo ngokuxhaswa kwangoku kunye ne-BHB yodwa.
Imingeni kunye neeNyaniso ze-BHB Supplementation
Nangona i-BHB inokubonelela ngolunye umthombo wamandla kwingqondo, ayilungi umba osisiseko wokuphazamiseka kwe-glucose ngenxa yokuxhatshazwa kwe-insulin. Ngaba uyazi kakuhle idosi ye-BHB okufuneka uyifake ukuze uphese i-organ ephezulu yamandla njengengqondo? Okanye ukulungisa ukungasebenzi kakuhle komzimba okuqhuba i-neuroinflammation? Ingakanani i-BHB yokuncedisa efunekayo, kwaye kaninzi kangakanani iya kulawula i-glutathione engapheliyo kwingqondo? Ngaba uyazi ukuba yeyiphi idosi efunekayo ukugcina kunye namanqanaba angoku oxinzelelo lwe-oxidative olubangelwa kukutya inqanaba lekhabhohayidrethi ephezulu kunempilo yomntu yangoku ye-metabolic inokusingatha? Ngaba uyasazi isixa sedosi kunye neshedyuli efunekayo ukunyanga ingqondo nangona umntu engenzi utshintsho olufunekayo ekunciphiseni ezi zinto zinegalelo kwisigulo sengqondo?
Awazi?
Nam futhi. Kwaye ngokunjalo nabaphandi.
Kodwa ngaphaya kokungazi idosi egqibeleleyo kuyo yonke ingqondo, kukho iingqwalasela zokwenyani malunga nokuxhomekeka kuphela kwizongezelelo zeBHB.
Ukuba usebenzisa i-BHB ityuwa (eyaziwa nangokuthi i-ketone salts), uya kunikezela ngokugqithiseleyo inxalenye yamaminerali ixesha elide ngaphambi kokuba ufumane umthombo wamandla ozinzileyo ukuze uphembelele ingqondo yakho.
Kodwa masithi ufumana isongezelelo se-D-BHB esingadibanisi neetyuwa (amaminerali), kuba zikhona kwimarike. Ngaphaya kweendleko ezinkulu zokusebenzisa izongezo ezilolo hlobo imini yonke – iindleko ezihlala zingavumelekanga kwabaninzi kwaye azikahlawulwa ziinkampani zeinshorensi okwangoku – kukho omnye umngeni endizibuza wona ngokwenene.
Uza kuthambisa njani ingqondo yakho ngelixa ulele? Xa ukutya kwakho okuphezulu kwe-carb kwenzeka kwisidlo ngenxa yokuba awuzange utshintshe ukutya kwakho, kwaye ukuxhathisa kwakho kwe-insulin akuvumeli inani elaneleyo okanye ubude bexesha lokuvelisa i-ketone ukwenzela ukuzinzisa amanethiwekhi e-neural, oko kuthetha ukuthini ukuba ingqondo izama ukuphilisa? Ndiza kukuxelela. Amanqanaba aphezulu eshukela egazi aqhubeka efaka isandla kwi-dysregulation ye-metabolic, apho ukuxhaswa kwe-BHB yodwa ayikwazi ukulungisa ngokupheleleyo.
I-BHB inezakhiwo ezichasayo, kodwa ishukela ephezulu yegazi engapheliyo kunye nokuxhatshazwa kwe-insulin kunokuqhubela phambili iindlela zokuvuvukala kwingqondo. I-BHB inokunciphisa ukuvuvukala okuthile, okusebenzayo njengomzimba womqondiso we-molecular ngokumelene nokuvuvukala okungapheliyo, kodwa ayinqandi impendulo eqhubekayo yokuvuvukala okubangelwa ukuziphatha kunye nezinto ezisingqongileyo ezibangela ukungalingani kwe-metabolic okuqhubekayo.
I-BHB inokunciphisa uxinzelelo lwe-oxidative, kodwa amanqanaba aphezulu eshukela egazi ngokuqhubekayo avelisa iintlobo ze-oksijeni ezisebenzayo, ukudala umjikelezo womonakalo we-oxidative. Ukuxhaswa kwe-BHB kunokunceda, kwaye ewe, inokusebenza njengendlela yayo ye-antioxidant, kodwa akusiyo isisombululo esipheleleyo soxinzelelo lwe-oxidative olubangelwa yi-hyperglycemia engapheliyo.
Ndingaqhubeka malunga nendlela ukunganyangeki kwe-insulin yobuchopho kuba negalelo ekuguquleni ukusebenza kwe-neurotransmitter, ukunciphisa i-neuroplasticity, i-hormonal dysregulation, kunye nokubeka esichengeni isithintelo segazi ebuchotsheni, kodwa ufumana umbono.
Kwakhona, masiyilahle inyani yokuba ukutshintsha ukutya kwakho kutshintsha i-microbiome yakho yamathumbu ngokumodareyitha amafutha akhoyo kwi-microbiota. Ukuba uqhubeka usitya ukutya kwakho okuqhelekileyo, isongezelelo seBHB asiyi kutshintsha into eyenziwa yi-gut microbiome yakho. Ngenxa yoko, usenokungalufumani utshintsho olunzulu kwi-microbiome yamathumbu esiyibonayo ephucula ukuxhuzula, enokuba yinxalenye yeziphumo zonyango olusebenzayo esilubonayo ekusebenziseni ukutya kwe-ketogenic kwizigulo zengqondo kunye nokuphazamiseka kwemithambo-luvo.
Amandla onyango e-BHB kwi-psychiatry ye-metabolic, ngokombono wam wangoku, isetyenziswe ngokufanelekileyo kwisakhelo sokutya kwe-ketogenic eyenziwe kakuhle. Oku kutya kubangela imeko ebanzi ye-metabolic ehamba ngaphaya kwemiphumo ye-BHB yokuncedisa, echaphazela imiba eyahlukeneyo yempilo yengqondo kunye nomsebenzi.
Nangona i-BHB ibonisa amandla ekuphembeleleni imiba ethile yokusebenza kwengqondo, andicingi ukuba iya kuphuma njenge-panacea. Ukuxhomekeka kuphela kwi-BHB yokuncedisa okanye i-ketone salts igxininise ukubaluleka kwempilo ye-metabolic kwimpilo yengqondo, enokubandakanya ukutya, ukunyangwa kwengqondo, kunye neenguqu zokuphila eziphucula impilo kunye nomsebenzi we-mitochondrial.
Isiphelo: Ukucingisisa nge-BHB yoNongezelelo kunye nempilo yengqondo
Masiyiqukumbele le nto ngebali.
Kudala, kwakukho ingqondo enengxaki yokungasebenzi kakuhle kwemetabolism. Ukuba obu buchopho bebuyindlu, bebuya kutshiswa ngamadangatye, okanye iindawo ezininzi ezivuthayo. Nangona ukuxhaswa kwe-BHB yangaphandle kunokunceda ukucima umlilo, njengokuba iibhakethi zamanzi ziya kwenza, asazi ukuba ingakanani iBHB eya kufuneka ukuyifeza. Kwaye ukuba akukho tshintsho lokutya okanye ukuziphatha okwenziwe ukuphucula umsebenzi we-metabolic kwingqondo, ngaba ukuxhaswa kweBHB ngokwenene kuya kuba yonyango? Okanye ngaba besiya kusebenzisa nje ukuxhaswa kweBHB njengolunye uhlobo lolawulo lweempawu, indlela esizama ngayo ngoku ukuyenza ngamayeza?
Ngoko kwakhona, ndiyayifumana. Awufuni ukutshintsha ukutya kwakho.
Kodwa ndiyazi ngenyani ukuba uninzi lwenu lufuna ngokwenene ukunyanga oonobangela bokugula ngengqondo kwaye niqhubeke nobomi benu, nisonwabisa inqanaba lakho eliphezulu lokusebenza. Ndiyazi ukuba abanye benu bondlekile ziimodeli zokunciphisa iimpawu. Zange kube kutheni uze ufuna unyango, kwaye wamkele amayeza anikezela kuphela ukuncipha kweempawu kuba yayiyiyo yonke into ababeyinikezela ngelo xesha.
Kwaye ndiyazi ukuba abanye benu bayakuvuyela ukuzama into enikezela nje ukunciphisa iimpawu. Kwaye loo nto ipholile, nayo. Wonke umntu unelungelo lokwazi zonke iindlela zokuziva ngcono. Kwaye ukuxhaswa kweBHB kunokukwenza oko kuwe. Ukuxhaswa kwe-BHB kunokuchaphazela amayeza, ngoko ke fumana i-prescriber (ethemba ukuba i-ketogenic-trained) ukuthetha ngee-pros and cons kunye nawe kumxholo weyeza zakho zangoku kunye nokuxilongwa.
Kungakhathaliseki ukuba yeyiphi inkampu ohleli kuyo ngoku, ndiyathemba ukuba eli nqaku libe luncedo ekuqondeni indima enokwenzeka yokuxhaswa kweBHB ekuziveni ngcono.
Ucaphulo
Cornuti, S., Chen, S., Lupori, L., Finamore, F., Carli, F., Samad, M., Fenizia, S., Caldarelli, M., Damiani, F., Raimondi, F., UMazziotti, R., Magnan, C., Rocchiccioli, S., Gastaldelli, A., Baldi, P., & Tognini, P. (2023). I-Brain histone beta-hydroxybutyrylation idibanisa i-metabolism kunye ne-gene expression. Iisayensi kunye nezoBomi beMolekyuli, 80(1), 28. https://doi.org/10.1007/s00018-022-04673-9
Yena, Y., Cheng, X., Zhou, T., Li, D., Peng, J., Xu, Y., & Huang, W. (2023). I-β-Hydroxybutyrate njenge-epigenetic modifier: Iindlela eziphantsi kunye neziphumo. IHeliyon, 9(11). https://doi.org/10.1016/j.heliyon.2023.e21098
Kovács, Z., D'Agostino, DP, Diamond, D., Kindy, MS, Rogers, C., & Ari, C. (2019). Amandla oNyango lwe-Exogenous Ketone Supplement eyenziwe yi-Ketosis kuNyango lweZiphazamiso zengqondo: Uphononongo loNcwadi lwangoku. Frontiers kwi-Psychiatry, 10. https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00363
Soto-Mota, A., Norwitz, NG, & Clarke, K. (2020). Kutheni i-d-β-hydroxybutyrate monoester? I-Biochemical Society Transactions, 48(1), 51-59. https://doi.org/10.1042/BST20190240
Storoschuk, KL, Wood, TR, & Stubbs, BJ (2023). Uphononongo olucwangcisiweyo kunye ne-meta-regression of exogenous ketone infusion rates kunye nesiphumo se-ketosis-Isixhobo seekliniki kunye nabaphandi. Imida kwiPhysics, 14, 1202186. https://doi.org/10.3389/fphys.2023.1202186
White, H., Heffernan, AJ, Worrall, S., Grunsfeld, A., & Thomas, M. (2021). Ukuphononongwa okuCwangcisiweyo kwe-Intravenous β-Hydroxybutyrate Ukusetyenziswa kuBantu - Unyango oluthembisayo lwexesha elizayo? Imida kwezamayeza, 8. https://www.frontiersin.org/articles/10.3389/fmed.2021.740374
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